Alex Loukas
- alex.loukas@jcu.edu.au
https://orcid.org/0000-0002-0896-8441- Director, Australian Institute of Tropical Health and Medicine
- Australian Institute of Tropical Health & Medicine
Projects
14
Publications
65
Awards
0
Biography
I obtained a BSc Hons in 1990 and a PhD in 1995 from University of Queensland in the field of immunoparasitology. I then conducted postdoctoral work at University of Edinburgh with Rick Maizels and an assistant professorship at George Washington University in the US to work with Peter Hotez and the Human Hookworm Vaccine Initiative. In 2004 I returned to Australia as an NHMRC Career Development Fellow at Queensland Institute of Medical Research where I established the Helminth Biology laboratory. In 2010 I moved to James Cook University in Cairns, QLD as a Tropical Research Leader, where I established the Centre for Biodiscovery and Molecular Development of Therapeutics. I have held consistent NHMRC funding in the form of fellowships (currently level 3 Investigator), program grants, project grants and development grants, as well as regular funding from the US National Institutes of Health and various pharmaceutical companies, including Merck and Johnson & Johnson. I am co-founder of Macrobiome Therapeutics, a start-up biotech company developing worm-derived proteins as anti-inflammatory therapeutics.
My group is primarily interested in the secretomes of parasitic helminths, and the subsequent use of worm secreted proteins as therapeutics and diagnostic tools. Major projects in the lab include;
1. Use of worm proteins as novel anti-inflammatories for treating a range of autoimmune and allergic disorders of humans.
2. Clinical trials to assess the therapeutic properties of iatrogenic hookworm infection in human inflammatory and metabolic diseases
3. Use of proteome microarrays to discover vaccine and diagnostic antigens for human helminth infections.
4. Understanding the mechanisms by which parasitic helminths suppress (and in some cases, drive) immunopathology with a particular emphasis on extracellular proteins and vesicles.
In addition to my role at JCU, I serve as deputy editor of the International Journal for Parasitology.
Research
Projects
Enhancing Australian biodiscovery molecule generation, storage and access. (Old ID 28931)
24 Feb 2023 - 31 Dec 2023
Next-generation therapeutics inspired by parasitic helminths. (Old ID 27418)
01 Jan 2022 - 31 Dec 2026
Novel therapeutics for diabetes sourced from Northern Australian biota. (Old ID 27321)
01 Jul 2021 - 30 Jun 2022
Personal Protective Biosystems - Membranes and commensal helminths (MaCH) (Old ID 26776)
15 Apr 2021 - 14 Apr 2026
Tools to diagnose carcinogenic liver fluke infection (Old ID 26496)
01 Mar 2020 - 28 Feb 2023
Hookworm peptide therapeutic for oral treatment of IBD (Old ID 26317)
01 Jan 2020 - 30 Jun 2022
Pre-clinical development of a liver fluke growth factor for treating non-healing wounds (Old ID 23529)
01 Aug 2017 - 30 Jun 2020
Helminth secretomes: from vaccines to novel anti-inflammatory biologics (Old ID 22726)
01 Jan 2017 - 31 Dec 2021
Tools to control Schistosomiasis (Old ID 22805)
01 Jul 2016 - 30 Jun 2019
Secreted exosome-like vesicles from the carcinogenic liver fluke (Old ID 21477)
01 Jan 2015 - 31 Dec 2018
Tropical Disease - Immunity, pathogenesis and vaccine development: global translation (Old ID 20729)
01 Jan 2013 - 31 Dec 2017
Role of liver fluke granulin in cholangiocarcinogenesis (Old ID 19534)
01 Jan 2012 - 31 Jul 2018
Principal Research Fellowship (Old ID 19984)
01 Jan 2012 - 31 Dec 2016
Teaching
Research Advisor Accreditation
Advisor Type
Mentor
Output
Sikder, Suchandan; Pierce, Doris; Sarkar, Eti R.; McHugh, Connor; Quinlan, Kate G.R.; Giacomin, Paul; Loukas, Alex (2024) 'Regulation of host metabolic health by parasitic helminths'. Trends in Parasitology, 40 (5):386-400. [DOI]
Peck, Yoshimi; Pickering, Darren; Mobli, Mehdi; Liddell, Michael J.; Wilson, David T; Ruscher, Roland; Ryan, Stephanie; Buitrago, Geraldine; McHugh, Connor; Love, Nicholas C.; Pinlac, Theresa; Haertlein, Michael; Kron, Michael A.; Loukas, Alex; Daly, Norelle L. (2024) 'Solution structure of the N-terminal extension domain of a Schistosoma japonicum asparaginyl-tRNA synthetase'. Journal of Biomolecular Structure and Dynamics, 42 (15):7934-7944. [DOI]
Jamtsho, Tenzin; Yeshi, Karma; Perry, Matthew J.; Loukas, Alex; Wangchuk, Phurpa (2024) 'Approaches, Strategies and Procedures for Identifying Anti-Inflammatory Drug Lead Molecules from Natural Products'. Pharmaceuticals, 17 (13). [DOI]
Pharmaceutical Potential of Remedial Plants and Helminths for Treating Inflammatory Bowel Disease
2024
Jamtsho, Tenzin; Loukas, Alex; Wangchuk, Phurpa (2024) 'Pharmaceutical Potential of Remedial Plants and Helminths for Treating Inflammatory Bowel Disease'. Pharmaceuticals, 17 (7). [DOI]
Uzoechi, Samuel C.; Rosa, Bruce A.; Singh, Kumar Sachin; Choi, Young Jun; Bracken, Bethany K.; Brindley, Paul J.; Townsend, R. Reid; Sprung, Robert; Zhan, Bin; Bottazzi, Maria Elena; Hawdon, John M.; Wong, Yide; Loukas, Alex; Djuranovic, Sergej; Mitreva, Makedonka (2023) 'Excretory/Secretory Proteome of Females and Males of the Hookworm Ancylostoma ceylanicum'. Pathogens, 12 (1). [DOI]
Effect of experimental hookworm infection on insulin resistance in people at risk of type 2 diabetes
2023
Pierce, Doris R.; Mcdonald, Malcolm; Merone, Leanne; Becker, Luke; Thompson, Fintan; Lewis, Chris; Ryan, Rachael Y.M.; Hii, Sze Fui; Zendejas-Heredia, Patsy; Traub, Rebecca J.; Field, Matthew A.; Rahman, Tony; Croese, John; Loukas, Alex; McDermott, Robyn; Giacomin, Paul R. (2023) 'Effect of experimental hookworm infection on insulin resistance in people at risk of type 2 diabetes'. Nature Communications, 14 . [DOI]
Wangchuk, Phurpa; Yeshi, Karma; Loukas, Alex (2023) 'Metabolomics and lipidomics studies of parasitic helminths: molecular diversity and identification levels achieved by using different characterisation tools'. Metabolomics, 19 (63). [DOI]
Takjoo, Rozita; Wilson, David T.; Bansal, Paramjit S.; Loukas, Alex; Smout, Michael J.; Daly, Norelle L. (2023) 'Identification of an inter-cysteine loop potentially involved in the activity of Opisthorchis viverrini-granulin-1'. Exploration of Drug Science, 1 :172-179. [DOI]
Lennox-Bulow, Danica; Smout, Michael; Loukas, Alex; Seymour, Jamie (2023) 'Stonefish (Synanceia spp.) Ichthyocrinotoxins: An ecological review and prospectus for future research and biodiscovery'. Toxicon, 236 . [DOI]
Ruangsuwast, Apisit; Smout, Michael J.; Brindley, Paul J.; Loukas, Alex; Laha, Thewarach; Chaiyadet, Sujittra (2023) 'Tetraspanins from the liver fluke Opisthorchis viverrini stimulate cholangiocyte migration and inflammatory cytokine production'. Folia Parasitologica, 70 . [DOI]
White, Ruby; Sotillo, Javier; Ancarola, María Eugenia; Borup, Anne; Boysen, Anders Toftegaard; Brindley, Paul J.; Buzás, Edit I.; Cavallero, Serena; Chaiyadet, Sujittra; Chalmers, Iain W.; Cucher, Marcela A.; Dagenais, Maude; Davis, Chelsea N.; Devaney, Eileen; Duque-Correa, Maria A.; Eichenberger, Ramon Marc; Fontenla, Santiago; Gasan, Thomas A.; Hokke, Cornelis H.; Kosanovic, Maja; Kuipers, Marije E.; Laha, Thewarach; Loukas, Alex; Maizels, Rick M.; Marcilla, Antonio; Mazanec, Hynek; Morphew, Russell M.; Neophytou, Kyriaki; Nguyen, Linh Thuy; Nolte-‘t Hoen, Esther; Povelones, Michael; Robinson, Mark W.; Rojas, Alicia; Schabussova, Irma; Smits, Hermelijn H.; Sungpradit, Sivapong; Tritten, Lucienne; Whitehead, Bradley; Zakeri, Amin; Nejsum, Peter; Buck, Amy H.; Hoffmann, Karl F. (2023) 'Special considerations for studies of extracellular vesicles from parasitic helminths: A community-led roadmap to increase rigour and reproducibility'. Journal of Extracellular Vesicles, 12 (1). [DOI]
Chapman, Paul R.; Llewellyn, Stacey; Jennings, Helen; Becker, Luke; Giacomin, Paul; McDougall, Rodney; Robson, Jennifer; Loukas, Alex; McCarthy, James (2022) 'The production of Necator americanus larvae for use in experimental human infection'. Parasites & Vectors, 15 . [DOI]
Shalash, Ahmed O.; Becker, Luke; Yang, Jieru; Giacomin, Paul; Pearson, Mark; Hussein, Waleed M.; Loukas, Alex; Toth, Istvan; Skwarczynski, Mariusz (2022) 'Development of a peptide vaccine against hookworm infection: Immunogenicity, efficacy, and immune correlates of protection'. Journal of Allergy and Clinical Immunology, 150 (1):157-169.e10. [DOI]
Journal Publication
ResearchOnline@JCU
Langdon, Kane; Buitrago, Geraldine; Pickering, Darren; Giacomin, Paul; Loukas, Alex; Haleagrahara, Nagaraja (2022) 'Na-AIP-1 secreted by human hookworms suppresses collagen-induced arthritis'. Inflammopharmacology, 30 (2):527-535. [DOI]
Journal Publication
ResearchOnline@JCU
Khudhair, Zainab; Alhallaf, Rafid; Eichenberger, Ramon M.; Field, Matt; Krause, Lutz; Sotíllo, Javier; Loukas, Alex (2022) 'Administration of Hookworm Excretory/Secretory Proteins Improves Glucose Tolerance in a Mouse Model of Type 2 Diabetes'. Biomolecules, 12 (5). [DOI]
Quinzo, M.J.; Perteguer, M.J.; Brindley, P.J.; Loukas, A.; Sotillo, J. (2022) 'Transgenesis in parasitic helminths: a brief history and prospects for the future'. Parasites and Vectors, 15 (1). [DOI]
Ritmejeryte, Edita; Ryan, Rachael Y.M.; Byatt, Brendan J.; Peck, Yoshimi; Yeshi, Karma; Daly, Norelle L.; Zhao, Guangzu; Crayn, Darren; Loukas, Alex; Pyne, Stephen G.; Ruscher, Roland; Wangchuk, Phurpa (2022) 'Anti-inflammatory properties of novel galloyl glucosides isolated from the Australian tropical plant Uromyrtus metrosideros'. Chemico-Biological Interactions, 368 . [DOI]
Journal Publication
ResearchOnline@JCU
Chaiyadet, Sujittra; Tangkawattana, Sirikachorn; Smout, Michael J.; Ittiprasert, Wannaporn; Mann, Victoria H.; Deenonpoe, Raksawan; Arunsan, Patpicha; Loukas, Alex; Brindley, Paul J.; Laha, Thewarach (2022) 'Knockout of liver fluke granulin, Ov-grn-1, impedes malignant transformation during chronic infection with Opisthorchis viverrini'. PLoS Pathogens, 18 (9). [DOI]
Ryan, Stephanie M.; Ruscher, Roland; Johnston, Wayne A.; Pickering, Darren A.; Kennedy, Malcolm W.; Smith, Brian O.; Jones, Linda; Buitrago, Geraldine; Field, Matt A.; Esterman, Adrian J.; McHugh, Connor P.; Browne, Daniel J.; Cooper, Martha M.; Ryan, Rachael Y.M.; Doolan, Denise L.; Engwerda, Christian R.; Miles, Kim; Mitreva, Makedonka; Croese, John; Rahman, Tony; Alexandrov, Kirill; Giacomin, Paul R.; Loukas, Alex (2022) 'Novel antiinflammatory biologics shaped by parasite–host coevolution'. Proceedings of the National Academy of Sciences of the United States of America, 119 (36). [DOI]
Cobos, Claudia; Bansal, Paramjit S.; Wilson, David T.; Jones, Linda; Zhao, Guangzu; Field, Matthew A.; Eichenberger, Ramon M.; Pickering, Darren A.; Ryan, Rachael Y.M.; Ratnatunga, Champa N.; Miles, John J.; Ruscher, Roland; Giacomin, Paul R.; Navarro, Severine; Loukas, Alex; Daly, Norelle L. (2022) 'Peptides derived from hookworm anti-inflammatory proteins suppress inducible colitis in mice and inflammatory cytokine production by human cells'. Frontiers in Medicine, 9 . [DOI]
Chaiyadet, Sujittra; Sotillo, Javier; Krueajampa, Watchara; Thongsen, Sophita; Smout, Michael; Brindley, Paul J.; Laha, Thewarach; Loukas, Alex (2022) 'Silencing of Opisthorchis viverrini Tetraspanin Gene Expression Results in Reduced Secretion of Extracellular Vesicles'. Frontiers in Cellular and Infection Microbiology, 12 . [DOI]
De Sousa, Karina P.; Potriquet, Jeremy; Mulvenna, Jason; Sotillo-Gallego, Javier; Groves, Penny L.; Loukas, Alex; Apte, Simon H.; Doolan, Denise L. (2022) 'Proteomic identification of the contents of small extracellular vesicles from in vivo Plasmodium yoelii infection'. International Journal for Parasitology, 52 (1):35-45. [DOI]
Journal Publication
ResearchOnline@JCU
Yeshi, Karma; Ruscher, Roland; Loukas, Alex; Wangchuk, Phurpa (2022) 'Immunomodulatory and biological properties of helminth-derived small molecules: Potential applications in diagnostics and therapeutics'. Frontiers in Parasitology, 1 . [DOI]
Mekonnen, Gebeyaw G.; Tedla, Bemnet A.; Pearson, Mark S.; Becker, Luke; Field, Matt; Amoah, Abena S.; van Dam, Govert; Corstjens, Paul L.A.M.; Mduluza, Takafira; Mutapi, Francisca; Loukas, Alex; Sotillo, Javier (2022) 'Characterisation of tetraspanins from Schistosoma haematobium and evaluation of their potential as novel diagnostic markers'. PLoS Neglected Tropical Diseases, 16 (1). [DOI]
Schmidt, Casey A.; Cooke, Ira; Wilson, David T.; Miller, David J.; Peigneur, Steve; Tytgat, Jan; Field, Matthew; Takjoo, Rozita; Smout, Michael J.; Loukas, Alex; Daly, Norelle L. (2022) 'Newly Discovered Peptides from the Coral Heliofungia actiniformis Show Structural and Functional Diversity'. Journal of Natural Products, 85 (7):1789-1798. [DOI]
Journal Publication
ResearchOnline@JCU
Buitrago, Geraldine; Pickering, Darren; Ruscher, Roland; Cobos Caceres, Claudia; Jones, Linda; Cooper, Martha; Van Waardenberg, Ashley; Ryan, Stephanie; Miles, Kim; Field, Matthew; Dredge, Keith; Daly, Norelle L.; Giacomin, Paul R.; Loukas, Alex (2021) 'A netrin domain-containing protein secreted by the human hookworm Necator americanus protects against CD4 T cell transfer colitis'. Translational Research, 232 :88-102. [DOI]
Chapman, Paul R.; Giacomin, Paul; Loukas, Alex; McCarthy, James S. (2021) 'Experimental human hookworm infection: a narrative historical review'. PLoS Neglected Tropical Diseases, 15 (12). [DOI]
Chapman, Paul R.; Webster, Rebecca; Giacomin, Paul; Llewellyn, Stacey; Becker, Luke; Pearson, Mark; De Labastida Rivera, Fabian; O’Rourke, Peter; Engwerda, Christian R.; Loukas, Alex; McCarthy, James S. (2021) 'Vaccination of human participants with attenuated Necator americanus hookworm larvae and human challenge in Australia: a dose-finding study and randomised, placebo-controlled, phase 1 trial'. Lancet Infectious Diseases, 21 (12):1725-1736. [DOI]
Journal Publication
ResearchOnline@JCU
Pearson, Mark S.; Tedla, Bemnet A.; Mekonnen, Gebeyaw G.; Proietti, Carla; Becker, Luke; Nakajima, Rie; Jasinskas, Al; Doolan, Denise L.; Amoah, Abena S.; Knopp, Stefanie; Rollinson, David; Ali, Said M.; Kabole, Fatma; Hokke, Cornelis H.; Adegnika, Akim A.; Field, Matt A.; van Dam, Govert; Corstjens, Paul L.A.M.; Mduluza, Takafira; Mutapi, Francisca; Oeuvray, Claude; Greco, Beatrice; Chaiyadet, Sujittra; Laha, Thewarach; Cai, Pengfei; McManus, Donald P.; Bottazzi, Maria Elena; Felgner, Philip L.; Sotillo, Javier; Loukas, Alex (2021) 'Immunomics-guided discovery of serum and urine antibodies for diagnosing urogenital schistosomiasis: a biomarker identification study'. The Lancet Microbe, 2 (11):e617-e626. [DOI]
Wangchuk, Phurpa; Anderson, Dovile; Yeshi, Karma; Loukas, Alex (2021) 'Identification of small molecules of the infective stage of human hookworm using LCMS-based metabolomics and lipidomics protocols'. ACS Infectious Diseases, 7 :3264-3276. [DOI]
Journal Publication
ResearchOnline@JCU
Pearson, Mark S.; Tedla, Bemnet A.; Becker, Luke; Nakajima, Rie; Jasinskas, Al; Mduluza, Takafira; Mutapi, Francisca; Oeuvray, Claude; Greco, Beatrice; Sotillo, Javier; Felgner, Philip L.; Loukas, Alex (2021) 'Immunomics-guided antigen discovery for praziquantel-induced vaccination in urogenital human schistosomiasis'. Frontiers in Immunology, 12 . [DOI]
Smallwood, Taylor B.; Navarro, Severine; Cristofori-Armstrong, Ben; Watkins, Thomas S.; Tungatt, Katie; Ryan, Rachael Y.M.; Haigh, Oscar L.; Lutzky, Viviana P.; Mulvenna, Jason P.; Rosengren, Karl Johan; Loukas, Alex; Miles, John J.; Clark, Richard J. (2021) 'Synthetic hookworm-derived peptides are potent modulators of primary human immune cell function that protect against experimental colitis in vivo'. Journal of Biological Chemistry, 297 (1). [DOI]
Phumrattanaprapin, Wuttipong; Pearson, Mark; Pickering, Darren; Tedla, Bemnet; Smout, Michael; Chaiyadet, Sujittra; Brindley, Paul J.; Loukas, Alex; Laha, Thewarach (2021) 'Monoclonal antibodies targeting an opisthorchis viverrini extracellular vesicle tetraspanin protect hamsters against challenge infection'. Vaccines, 9 (7). [DOI]
Phumrattanaprapin, Wuttipong; Chaiyadet, Sujittra; Brindley, Paul J.; Pearson, Mark; Smout, Michael J.; Loukas, Alex; Laha, Thewarach (2021) 'Orally administered Bacillus spores expressing an extracellular vesicle-derived tetraspanin protect hamsters against challenge infection with carcinogenic human liver fluke'. Journal of Infectious Diseases, 223 (8):1445-1455. [DOI]
Journal Publication
ResearchOnline@JCU
Shalash, Ahmed O.; Becker, Luke; Yang, Jieru; Giacomin, Paul; Pearson, Mark; Hussein, Waleed M.; Loukas, Alex; Skwarczynski, Mariusz; Toth, Istvan (2021) 'Oral peptide vaccine against hookworm infection: correlation of antibody titers with protective efficacy'. Vaccines, 9 . [DOI]
Cholangiocarcinoma
2021
Brindley, Paul J.; Bachini, Melinda; Ilyas, Sumera I.; Khan, Shahid A.; Loukas, Alex; Sirica, Alphonse E.; Teh, Bin Tean; Wongkham, Sopit; Gores, Gregory J. (2021) 'Cholangiocarcinoma'. Nature Reviews Disease Primers, 7 :1-17. [DOI]
Journal Publication
ResearchOnline@JCU
Montaño, Karen J.; Loukas, Alex; Sotillo, Javier (2021) 'Proteomic approaches to drive advances in helminth extracellular vesicle research'. Molecular Immunology, 131 :1-5. [DOI]
Journal Publication
ResearchOnline@JCU
Mairiang, Eimorn; Laha, Thewarach; Kaewkes, Sasithorn; Loukas, Alex; Bethony, Jeffrey; Brindley, Paul j.; Sripa, Banchob (2021) 'Hepatobiliary morbidities detected by ultrasonography in Opisthorchis viverrini-infected patients before and after praziquantel treatment: a five-year follow up study'. Acta Tropica, 217 . [DOI]
Journal Publication
ResearchOnline@JCU
Khudhair, Zainab; Alhallaf, Rafid; Eichenberger, Ramon M.; Whan, Jen; Kupz, Andreas; Field, Matt; Krause, Lutz; Wilson, David T.; Daly, Norelle L.; Giacomin, Paul; Sotillo, Javier; Loukas, Alex (2021) 'Gastrointestinal helminth infection improves insulin sensitivity, decreases systemic inflammation, and alters the composition of gut microbiota in distinct mouse models of Type 2 diabetes'. Frontiers in Endocrinology, 11 . [DOI]
Loukas, Alex; Maizels, Rick M.; Hotez, Peter J. (2021) 'The yin and yang of human soil-transmitted helminth infections'. International Journal for Parasitology, 51 (13-14):1243-1253. [DOI]
Journal Publication
ResearchOnline@JCU
Arunsan, Patpicha; Chaidee, Apisit; Cochran, Christina J.; Mann, Victoria H.; Tanno, Toshihiko; Kumkhaek, Chutima; Smout, Michael J.; Karinshak, Shannon E.; Rodpai, Rutchanee; Sotillo, Javier; Loukas, Alex; Laha, Thewarach; Brindley, Paul J.; Ittiprasert, Wannaporn (2020) 'Liver fluke granulin promote extracellular vesicle-mediated crosstalk and cellular microenvironment conducive to cholangiocarcinoma'. Neoplasia, 22 (5):203-216. [DOI]
Thi Phung, Luyen; Chaiyadet, Sujittra; Hongsrichan, Nuttanan; Sotillo, Javier; Dinh Thi Dieu, Hang; Quang Tran, Canh; Brindley, Paul J.; Loukas, Alex; Laha, Thewarach (2020) 'Partial protection with a chimeric tetraspanin-leucine aminopeptidase subunit vaccine against Opisthorchis viverrini infection in hamsters'. Acta Tropica, 204 . [DOI]
Journal Publication
ResearchOnline@JCU
Yeshi, Karma; Ruscher, Roland; Hunter, Luke; Daly, Norelle; Loukas, Alex; Wangchuk, Phurpa (2020) 'Revisiting inflammatory bowel disease: pathology, treatments, challenges and emerging therapeutics including drug leads from natural products'. Journal of Clinical Medicine, 9 (5). [DOI]
Kifle, Desalegn Woldeyohannes; Pearson, Mark S.; Becker, Luke; Pickering, Darren; Loukas, Alex; Sotillo, Javier (2020) 'Proteomic analysis of two populations of Schistosoma mansoni-derived extracellular vesicles: 15k pellet and 120k pellet vesicles'. Molecular and Biochemical Parasitology, 236 . [DOI]
Journal Publication
ResearchOnline@JCU
Bartlett, Stacey; Eichenberger, Ramon M.; Nevagi, Reshma J.; Ghaffar, Khairunnisa Abdul; Marasini, Nirmal; Dai, Yang; Loukas, Alex; Toth, Istvan; Skwarczynski, Mariusz (2020) 'Lipopeptide-based oral vaccine against hookworm infection'. Journal of Infectious Diseases, 221 (6):934-942. [DOI]
Journal Publication
ResearchOnline@JCU
Bouchery, Tiffany; Moyat, Mati; Sotillo, Javier; Silverstein, Solomon; Volpe, Beatrice; Coakley, Gillian; Tsourouktsoglou, Theodora-Dorita; Becker, Luke; Shah, Kathleen; Kulagin, Manuel; Guiet, Romain; Camberis, Mali; Schmidt, Alfonso; Seitz, Arne; Giacomin, Paul; Le Gros, Graham; Papayannopoulos, Venizelos; Loukas, Alex; Harris, Nicola L. (2020) 'Hookworms evade host immunity by secreting a deoxyribonuclease to degrade neutrophil extracellular traps'. Cell Host & Microbe, 27 (2):277-289.e6. [DOI]
Journal Publication
ResearchOnline@JCU
Yeshi, Karma; Creek, Darren J.; Anderson, Dovile; Ritmejerytė, Edita; Becker, Luke; Loukas, Alex; Wangchuk, Phurpa (2020) 'Metabolomes and lipidomes of the infective stages of the gastrointestinal nematodes, Nippostrongylus brasiliensis and Trichuris muris'. Metabolites, 10 (11). [DOI]
Croese, John; Miller, Gregory C.; Marquart, Louise; Llewellyn, Stacey; Gupta, Rohit; Becker, Luke; Clouston, Andrew D.; Welch, Christine; Sidorenko, Julia; Wallace, Leanne; Visscher, Peter M.; Remedios, Matthew L.; McCarthy, James S.; O'Rourke, Peter; Radford-Smith, Graham; Loukas, Alex; Norrie, Mark; Masson, John W.; Gearry, Richard B.; Rahman, Tony; Giacomin, Paul (2020) 'Randomized, placebo controlled trial of experimental hookworm infection for improving gluten tolerance in Celiac disease'. Clinical and Translational Gastroenterology, 11 . [DOI]
Tedla, Bemnet; Pickering, Darren; Becker, Luke; Loukas, Alex; Pearson, Mark S. (2020) 'Vaccination with Schistosoma mansoni cholinesterases reduces the parasite burden and egg viability in a mouse model of Schistosomiasis'. Vaccines, 8 (2). [DOI]
Ng, Susanna S.; Rivera, Fabian De Labastida; Yan, Juming; Corvino, Dillon; Das, Indrajit; Zhang, Ping; Kuns, Rachel; Chauhan, Shashi Bhushan; Hou, Jiajie; Li, Xian-Yang; Frame, Teija C.M.; McEnroe, Benjamin A.; Moore, Eilish; Na, Jinrui; Engel, Jessica A.; Soon, Megan S. F.; Singh, Bhawana; Kueh, Andrew J.; Herold, Marco J.; de Oca, Marcela Montes; Singh, Siddharth Sankar; Bunn, Patrick T.; Aguilera, Amy Roman; Casey, Mika; Braun, Matthias; Ghazanfari, Nazanin; Wani, Shivangi; Wang, Yulin; Amante, Fiona; Edwards, Chelsea L.; Haque, Ashraful; Dougall, William C.; Singh, Om Prakash; Baxter, Alan G.; Teng, Michele W.L.; Loukas, Alex; Daly, Norelle L.; Cloonan, Nicole; Degli-esposti, Mariapia; Uzonna, Jude; Heath, William R.; Bald, Tobias; Tey, Siok-Keen; Nakamura, Kyohei; Hill, Geoffrey R.; Kumar, Rajiv; Sundar, Shyam; Smyth, Mark J; Engwerda, Christian R. (2020) 'The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation'. Nature Immunology, 21 :1205-1217. [DOI]
Journal Publication
ResearchOnline@JCU
Suwannatrai, Kulwadee; Suwannatrai, Apiporn Thinkhamrop; Loukas, Alex; Sotillo, Javier (2020) 'Recent advances on the immunobiology of Bithynia spp. hosts of Opisthorchis viverrini'. Developmental and Comparative Immunology, 102 . [DOI]
Journal Publication
ResearchOnline@JCU
Kifle, Desalegn Woldeyohannes; Chaiyadet, Sujittra; Waardenberg, Ashley J.; Wise, Ingrid; Cooper, Martha; Becker, Luke; Doolan, Denise L.; Laha, Thewarach; Sotillo, Javier; Pearson, Mark S.; Loukas, Alex (2020) 'Uptake of Schistosoma mansoni extracellular vesicles by human endothelial and monocytic cell lines and impact on vascular endothelial cell gene expression'. International Journal for Parasitology, 50 (9):685-696. [DOI]
Journal Publication
ResearchOnline@JCU
Logan, Jayden; Pearson, Mark S.; Manda, Srikanth S.; Choi, Young-Jun; Field, Matthew; Eichenberger, Ramon M.; Mulvenna, Jason; Nagaraj, Shivashankar H.; Fujiwara, Ricardo T.; Gazzinelli-Guimaraes, Pedro; Bueno, Lilian; Mati, Vitor; Bethony, Jeffrey M.; Mitreva, Makedonka; Sotillo, Javier; Loukas, Alex (2020) 'Comprehensive analysis of the secreted proteome of adult Necator americanus hookworms'. PLoS Neglected Tropical Diseases, 14 (5). [DOI]
Ryan, Stephanie M.; Eichenberger, Ramon M.; Ruscher, Roland; Giacomin, Paul R.; Loukas, Alex (2020) 'Harnessing helminth-driven immunoregulation in the search for novel therapeutic modalities'. PLoS Pathogens, 16 (5). [DOI]
Schmidt, Casey A.; Wilson, David T.; Cooke, Ira; Potriquet, Jeremy; Tungatt, Katie; Muruganandah, Visai; Boote, Chloe; Kuek, Felicity; Miles, John J.; Kupz, Andreas; Ryan, Stephanie; Loukas, Alex; Bansal, Paramjit S.; Takjoo, Rozita; Miller, David J.; Peigneur, Steve; Tytgat, Jan; Daly, Norelle (2020) 'Identification and characterization of a peptide from the stony coral Heliofungia actiniformis'. Journal of Natural Products, 83 (11):3454-3463. [DOI]
Journal Publication
ResearchOnline@JCU
Mbanefo, Evaristus C.; Agbo, Chinwike Terry; Zhao, Yuanlong; Lamanna, Olivia K.; Thai, Kim H.; Karinshak, Shannon E.; Khan, Mohammad Afzal; Fu, Chi-Ling; Odegaard, Justin I.; Saltikova, Irina V.; Smout, Michael J.; Pennington, Luke F.; Nicolls, Mark R.; Jardetzky, Theodore S.; Loukas, Alex; Brindley, Paul J.; Falcone, Franco H.; Hsieh, Michael H. (2020) 'IPSE, an abundant egg-secreted protein of the carcinogenic helminth Schistosoma haematobium, promotes proliferation of bladder cancer cells and angiogenesis'. Infectious Agents and Cancer, 15 . [DOI]
Takjoo, Rozita; Wilson, David T.; Bansal, Paramjit; Loukas, Alex; Smout, Michael J.; Daly, Norelle L. (2020) 'Folding of truncated granulin peptides'. Biomolecules, 10 (8). [DOI]
Mekonnen, Gebeyaw G.; Tedla, Bemnet A.; Pickering, Darren; Becker, Luke; Wang, Lei; Zhan, Bin; Bottazzi, Maria Elena; Loukas, Alex; Sotillo, Javier; Pearson, Mark S. (2020) 'Schistosoma haematobium extracellular vesicle proteins confer protection in a heterologous model of schistosomiasis'. Vaccines, 8 (3). [DOI]
Wangchuk, Phurpa; Lavers, Owen; Wishart, David; Loukas, Alex (2020) 'Excretory/secretory metabolome of the zoonotic roundworm parasite Toxocara canis'. Biomolecules, 10 (8). [DOI]
Aroian, Raffi V.; Loukas, Alex; Martin, Richard J. (2023) 'Anthelmintics V: Drugs, resistance, and vaccines' International Journal for Parasitology, 53 (8) :391-392. [DOI]
Journal Contribution
ResearchOnline@JCU
Kamath, Sandip D.; Liu, Tiange; Giacomin, Paul; Loukas, Alex; Navarro, Severine; Lopata, Andreas L. (2022) 'Mollusk allergy: Not simply cross-reactivity with crustacean allergens' Allergy, 77 (10) :3127-3130. [DOI]
Loukas, Alex; Croese, John; Rees, Megan A.; McCarthy, James S. (2022) 'Not All Worms Were Created Equal' Frontiers in Immunology, 13 . [DOI]
Ryan, Rachael Y.M.; Seymour, Jamie; Loukas, Alex; Lopez, J. Alejandro; Ikonomopoulou, Maria P.; Miles, John J. (2021) 'Immunological responses to envenomation' Frontiers in Immunology, 12 . [DOI]
Hoffmann, Karl F.; Hokke, Cornelis H.; Loukas, Alex; Buck, Amy H. (2020) 'Helminth extracellular vesicles: great balls of wonder' International Journal for Parasitology, 50 (9) :621-622. [DOI]
Journal Contribution
ResearchOnline@JCU
Hays, Russell; Pierce, Doris; Giacomin, Paul; Loukas, Alex; Bourke, Peter; McDermott, Robyn (2020) 'Helminth coinfection and COVID-19: an alternate hypothesis' PLoS Neglected Tropical Diseases, 14 (8) . [DOI]