Carcinogenic liver fluke infection: Gene editing- and vaccination-mediated approaches to interrupt host-parasite communication (Old ID 24789)

National Institute of Health
Alex Loukas
Role

Principal Investigator

Description

Long term infection with liver fluke - a food-borne parasitic worm - leads to cholangiocarcinoma (CCA), a form of liver cancer with a dismal prognosis. Previously we identified proteins and vesicles from these parasites that may cause this cancer. This new project will investigate the roles of these parasite proteins and vesicles in cancer, which may lead to new treatments and control for fluke infection and CCA.

Date

01 Aug 2018 - 31 Jul 2023

Project Type

GRANT

Keywords

Cancer;Infectious disease;Parasite;CRISPR/Cas9;Vaccines

Funding Body

National Institute of Health

Amount

825673.95

Project Team

Javier Sotillo-Gallego;Michael Smout