Mollusk allergy: Not simply cross-reactivity with crustacean allergens

Kamath, Sandip D.;Liu, Tiange;Giacomin, Paul;Loukas, Alex;Navarro, Severine;Lopata, Andreas L.

Abstract

[Extract] To the Editor, Mollusk allergy is commonly thought of as clinical cross-reactivity after primary sensitization to shrimps, other crustaceans, or mites. Tropomyosin is the major allergen, with primary IgE sensitization in 70% of all shellfish allergies. A high frequency of IgE and basophil reactivity to several mollusk allergens is seen in crustacean and mite-sensitized patients. It is still unclear, however, whether mollusks are capable of producing primary allergic sensitization, or whether IgE reactivity is based solely on cross-reactive crustacean-specific antibodies.

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1398-9995

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Wiley-Blackwell

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DOI

10.1111/all.15377