College of Medicine & Dentistry

Semagn Abate

Semagn Abate

Joseph Kamara

Joseph Kamara

Eric Kalo

Eric Kalo

Erin Waters

Erin Waters

Kannan Maharajan

Kannan Maharajan

Fahmida Begum Mina

Fahmida Begum Mina

Lynsey Brown

Lynsey Brown

Ali Isin

Ali Isin

Muideen Olaiya

Muideen Olaiya

Mila Grinblat

Mila Grinblat

Tilapia Biocontrol Project. (Old ID 27044)
Ellen Ariel
01 Jul 2020 - 31 Oct 2022
Determine the susceptibility of two tilapia species present in Australian waterways (O. mossambicus and T. mariae ) to TiLV and demonstrate the efficacy of TiLV as a potential biocontrol agent for tilapia in Australia.
Working it Out Together! Aboriginal and Torres Strait Islander led co-design for a strong and deadly health workforce (Old ID 27074)
Sarah Larkins
01 Sep 2021 - 31 Aug 2026
Building a stable, well-trained and culturally safe health workforce is a crucial part of delivering high quality primary health care (PHC) services. Previous attempts to strengthen rural/remote health workforce have failed, partly because they have not integrated Aboriginal and Torres Strait Islander knowledge and lived experience with necessary policy and systems support. There has been little research into culturally safe strategies to improve workforce stability in complex PHC context. This project will bridge these gaps through a community-led, place-based planning approach, engaging service providers, policy-makers and funders to co-design workforce strategies and models of care that are locally relevant, successful and sustainable. This community-based participatory project uses a mixed methods quasi-experimental pre-post design to implement co-designed actions to explore: How do we systematically embed Aboriginal and Torres Strait Islander perspectives into place-based planning and action for a stable and effective workforce that engenders community trust in local PHC delivery? Working with key sector partners in four service-based rural/remote clusters across Qld, NT and NSW, we will co-design and trial strategies to strengthen workforce competency and stability (by strengthening local career pathways for Indigenous people and strengthening cultural competency of non-Indigenous staff), and use community-centred impact and economic evaluation. Our team is majority Aboriginal and Torres Strait Islander and builds on relationships and learnings developed through our ongoing PHC system improvement work. Each jurisdictional team comprises a local Indigenous PHC service, community-controlled peak body, primary health network, government health department and university partner. This optimal mix will ensure successful implementation of sustainable strategies and translation into policy and practice for improved community access to quality PHC and health outcomes.
Resistance to inundation in green turtle eggs (Old ID 21938)
Ellen Ariel
01 Dec 2014 - 30 Nov 2017
The experiments will compare the susceptibility of green turtle eggs to inundation during different stages of their development.
Preventing reperfusion injury in stroke with an acutely dosed NK1R antagonist prodrug (Old ID 27621)
Alan Nimmo
01 Jan 2022 - 31 Dec 2023
Stroke represents a major clinical and societal burden, being a leading cause of adult disability, dementia, and death. The aim is to develop a novel therapeutic approach to significantly improve patient outcomes following an ischaemic stroke through the development of a novel therapeutic agent that can be delivered in conjunction with current approved reperfusion therapy. The plan involves critical de-risking efforts to deliver a low-risk strategy for progression to clinical trial. The plan focuses on the development of prodrugs of the NK1R antagonist, befetupitant, appropriately soluble for i.v. dosing, and accompanied by preclinical PK-PD data for formal, rapid preclinical development.
The impact of emergency care workforce policy on health equity: a comparative analysis (Old ID 27833)
Steph Topp
01 Jun 2022 - 31 May 2023
The purpose of this proposal is to develop a cross-country comparative research study on the linkages between emergency care workforce policy and health equity. The activities sponsored by this grant will facilitate the development of a comparative study to be submitted to the Canadian Institutes of Health Research on multi-stakeholder perspectives on the impact of emergency care workforce policy on health equity in Canada, Australia, Rwanda, and South Africa. This proposal uniquely brings together a team with complimentary skills in health policy and systems research, emergency medicine and epidemiology, perspectives that are each essential to unpacking emergency care workforce policy.
Assessment of Renal Function in Neonates and infants using Cystatin C. (Old ID 27135)
Danica Vojisavljevic
26 Feb 2021 - 31 Dec 2022
Diagnosis of early acute kidney injury (AKI) can prevent renal failure in babies (<2 years of age). This non-invasive method validation study will utilise parallel alternative method testing for renal function tests, to examine the clinical applicability and accuracy of implementing Cystatin-C (Cys-C), as a preferred biomarker for early AKI by: (1) determining if Cys-C is a more sensitive marker of impaired renal function and decline compared to serum creatinine in this cohort; (2) determine if eGFR derived from Cys-C is a more sensitive predictor of renal function decline; and (3) produce a clinical reference range for Cys-C for this cohort.
TRIAGE: A disease agnostic computational and modelling platform to accelerate variant classification (Old ID 27849)
Andrew Mallett
01 Jun 2022 - 31 May 2027
This proposal develops a disease-agnostic, high throughput and scalable functional genomics platform integrating computational variant prediction and disease modelling to increase the diagnostic rate of unresolved cases and accelerate development of experimental therapeutics. We implement a novel unsupervised, disease agnostic, genome-wide computational analysis method called TRIAGE which provides predictions at single base resolution across the human genome, revealing the likelihood of a variant being pathogenic. No other methods compare with TRIAGE in identifying genes associated with developmental process and cell differentiation where variants in these loci are associated with congenital disease and multi-organ syndromes. Our team of experts across Australia’s research and clinical sectors bring skills in bioinformatics, statistical genetics, clinical genetics, and disease modelling. In Aim 1 we incorporate tested genome-wide metrics, such as TRIAGE, to build open access machine learning methods that enhance variant prediction in clinical data. Aim 2 implements TRIAGE in Australian Genomic cohorts and registries to identify prioritised and novel candidates for disease modelling and develop strategies and guidelines for advancing TRIAGE in clinical genetic diagnostics and functional genomics networks. Aim 3 uses TRIAGE to prioritise variants for disease modelling across a multi-institutional phenotyping platform. Disease modelling includes innovative genome-wide molecular phenotyping coupled with physiological assays in cell and animal models. At the completion of the grant, we aim to implement TRIAGE in standard clinical genetic analysis protocols and deliver phenotyping data to assist in classification of unresolved genetic diseases. These achievements will result in diagnoses and mechanism of disease that will directly benefit patients in obtaining medical and psychosocial support and create pathways to new therapies.
Developing culturally appropriate assessments for people with dementia (Old ID 28929)
Sarah Russell
01 Apr 2022 - 31 Dec 2023
This study's aim is to develop culturally appropriate measures of anxiety and depression for older adults living with dementia in the Torres Strait. This is of significance given high rates of psychological distress identified in First Nations peoples. Outcomes from the study will (1) improve the accurate and timely diagnosis of comorbid psychological conditions in people with dementia; and (2) clarify differential diagnosis of dementia in older Torres Strait adults. Having culturally appropriate tools will facilitate equity of assessment for treatment within an underserved and disadvantaged group and ensure appropriate treatment and management within this vulnerable population of older adults.
Proposed development of revised framework for operational and implementation research in health and disease control programmes. (Old ID 27222)
Karen Carlisle
26 Apr 2021 - 24 Sep 2021
Strong, responsive and resilient health systems are the critical foundation for global health security. Health systems depend on effective functioning of both people and networks in order to implement effective disease control programmes, detect and respond quickly to infectious disease threats and develop evidence-informed policy/practice. The purpose of this work is to develop a revised framework for operational and implementation research (OR/IR) in health and disease control programs. This framework can be used to develop adequate and sustainable OR/IR capacity in public health programs and create an organisational culture of policy and practice that is informed by evidence-informed decision making.
Strengthening the Quality of Dementia Care in Aboriginal and Torres Strait Islander Residential Aged Care (Old ID 27652)
Yvonne Hornby-Turner
01 Feb 2022 - 31 May 2022
Aim: Develop and field-test an audit tool for assessing the standard of dementia care in Aboriginal/Torres Strait Islander residential aged care (RAC), against Quality Standards and Best Practice guidelines for dementia care. Method: - Undertake scoping review on best practice dementia care; - Develop a standardised audit tool based on scoping review evidence; - Field-test tool to evaluate face and content validity and inter-rater reliability. Outcome: Best practice dementia care audit tool and accompanying manual. Significance: Groundwork for a larger funding application to Dementia Australia that will test the audit tool and inform the feasibility and acceptability of a continuous quality improvement approach for strengthening dementia care in Aboriginal/Torres Strait Islander RAC.

Elevated intra-abdominal pressure limits venous return during exercise in Varanus exanthematicus

Terrestrial locomotion does not constrain venous return in the American alligator, Alligator mississippiensis

Regenerating lizard tails: A new model for investigating lymphangiogenesis

  • 2003
  • Researchers:Suzy Munns

Exploring the development of an appropriate women's health service for Mt Isa City: report to the Queensland Nursing Council Research Committee

Association of osteoprotegerin with human abdominal aortic aneurysm progression

EST analysis of the cnidarian Acropora millepora reveals extensive gene loss and rapid sequence divergence in the model invertebrates

The evolutionary history of the coral genus Acropora (Scleractinia, Cnidaria) based on a mitochondrial and a nuclear marker: reticulation, incomplete lineage sorting, or morphological convergence?

A simple plan: cnidarians and the origins of developmental mechanisms

Patterns of coral-dinoflagellate associations in Acropora: significance of local availability and physiology of Symbiodinium strains and host-symbiont selectivity

Maintenance of ancestral complexity and non-metazoan genes in two basal cnidarians

Title: Society for Free Radical Biology and Medicine (SFRBM)
Reseracher: Haleagrahara Nagaraja (Head, Foundation Studies)
Start Date: 01 Jan 2007
Title: American Physiological Society (APS)
Reseracher: Haleagrahara Nagaraja (Head, Foundation Studies)
Start Date: 01 Jan 2005
Title: The Society for Free Radical Biology and Medicine (SFRBM) – Annual Meeting Abstract Judge
Reseracher: Haleagrahara Nagaraja (Head, Foundation Studies)
Start Date: 01 Jan 2008
Title: Research Infrastructure Funding ($12,500 - Chief Investigator)
Reseracher: Joseph Moxon (Principal Research Fellow)
Start Date: 01 Jan 2010
Title: Associate Dean, Research, College of Medicine and Dentistry, James Cook University
Reseracher: Sarah Larkins (Dean, Medicine and Dentistry)
Start Date: 01 Jan 2014
End Date: 01 Jan 2019
Title: Faculty Administered Internal Grant Principal Investigator ($14,000)
Reseracher: Alex Trollope (Associate Professor)
Start Date: 01 Jan 2014
Title: Faculty Administered Internal Grant Principal Investigator ($6,500)
Reseracher: Alex Trollope (Associate Professor)
Start Date: 01 Jan 2009
Title: Fresh Science Alumnus, Science in Public, Australia
Reseracher: Hayley Letson (Senior Research Fellow)
Start Date: 01 Jan 2015
End Date: 01 Jan 2015
Title: General Practitioner, Health and Wellbeing North Ward
Reseracher: Sarah Larkins (Dean, Medicine and Dentistry)
Start Date: 01 Jan 2007
End Date: 01 Jan 2019
Title: Associate Professor, James Cook University
Reseracher: Sarah Larkins (Dean, Medicine and Dentistry)
Start Date: 01 Jan 2011
End Date: 01 Jan 2015