Hayley Letson
- hayley.letson@jcu.edu.au
https://orcid.org/0000-0003-0135-134X- Senior Research Fellow
- Medicine
Projects
6
Publications
86
Awards
11
Biography
I am a Senior Research Fellow in the Heart, Sepsis and Trauma Research Laboratory (HSTRL) in the College of Medicine and Dentistry, at James Cook University (JCU). After graduating with a University Medal from JCU with a Bachelor of Science majoring in Physiology and Pharmacology and Biochemistry and Molecular Biology, I joined the HSTRL in 2008 where I undertook a PhD developing a small-volume resuscitation solution comprising adenosine, lidocaine and magnesium (ALM) for the treatment of hemorrhagic shock and traumatic injury. Since 2012 I have been working with the US Military to translate ALM resuscitation fluid into the field, and in addition, I am focussed on improving emergency trauma care for patients in regional, rural and remote Australia. As well as haemorrhage shock and traumatic injury, my areas of expertise are coagulopathy, orthopaedics, surgery and surgical trauma, traumatic brain injury, burns, cardiovascular medicine, ischaemia-reperfusion, sepsis, infection, prehospital medicine, and rural and remote health. I am an ethics and research governance specialist, with 5 years' experience as a human research ethics advisor and currently hold the position of Deputy Chair of the JCU Human Research Ethics Committee. I have a strong background in science communication and received a 2021 Queensland Young Tall Poppy Award by the Australian Institute of Policy and Science.
Watch my TEDx Talk "Ten Minutes to Save a Life"
Collaborations:
- Aarhus University Hospital, Denmark
- Orthopaedic Research Institute of Queensland (ORIQL)
- Madigan Army Medical Center, Tacoma, Washington, USA
- US Special Operations Command (USSOCOM), Tampa, Florida
- Naval Mediccal Research Unit San Antonio (NAMRU-SA), Texas, USA
- Naval Medical Research Center (NMRC), Maryland, USA
- US Army Institute of Surgical Research, Ft. Sam, Houston
Engagement:
Guest Lecture University of Leuven, Belgium "Animal Models of Traumatic Injury and Critical Illness"
Australian Brain Alliance EMCR Network Townsville Showcase
Research
Projects
Trauma Care in the Tropics: A Multi-centre Retrospective Analysis. (Old ID 26855)
01 Jul 2020 - 31 Dec 2021
Teaching
Research Advisor Accreditation
Role
Chair; Independent Academic
Taught Modules
2024
Current JCU Research Students
Primary Prevention Implantable Cardiac Defribrillators: A North Queensland Perspective
Doctor of Philosophy (Health)
Activities
Associations
Awards
Media
Output
Letson, Hayley Louise (2016) Development of a small-volume resuscitation fluid for trauma victims. [Thesis] [DOI]
Morris, Jodie; Letson, Hayley; Dobson, Geoffrey (2024) 'Safety evaluation of adenosine, lidocaine and magnesium
(ALM) intranasal therapy toward human nasal epithelial
cells in vitro'. Basic and Clinical Pharmacology and Toxicology, 135 (1):98-108. [DOI]
Chequer de Souza, Julia; Letson, Hayley L.; Gibbs, Clinton R.; Dobson, Geoffrey P. (2024) 'The burden of head trauma in rural and remote North Queensland, Australia'. Injury, 55 (3). [DOI]
Davenport, Lisa M.; Letson, Hayley L.; Dobson, Geoffrey P. (2024) 'Lung protection after severe thermal burns with adenosine, lidocaine, and magnesium (ALM) resuscitation and importance of shams in a rat model'. Journal of Burn Care and Research, 45 (1). [DOI]
Pathophysiology of severe burn injuries: new therapeutic opportunities from a systems perspective
2024
Dobson, Geoffrey P.; Morris, Jodie L.; Letson, Hayley L. (2024) 'Pathophysiology of severe burn injuries: new therapeutic opportunities from a systems perspective'. Journal of Burn Care and Research, 45 (4):1041-1050. [DOI]
Morris, Jodie L.; Letson, Hayley L.; McEwen, Peter C.; Dobson, Geoffrey P. (2024) 'Adenosine, lidocaine, and magnesium therapy augments joint tissue healing following experimental anterior cruciate ligament rupture and reconstruction'. Bone & Joint Research, 13 (6):279-293. [DOI]
Chequer de Souza, Julia; Dobson, Geoffrey P.; Lee, Celine J.; Letson, Hayley L. (2024) 'Epidemiology and outcomes of brain trauma in rural and urban populations: a systematic review and meta-analysis'. Brain Injury, 38 (12):953-976. [DOI]
Dobson, Geoffrey; Letson, Hayley; Morris, Jodie (2024) 'Revolution in sepsis: a symptoms-based to a systems-based approach?'. Journal of Biomedical Science, 31 . [DOI]
Letson, Hayley; Morris, Jodie; Dobson, Geoffrey (2023) 'Changes in plasma alpha-1 acid glycoprotein following hemorrhagic trauma: Possible role in dose differences of ALM drug therapy in rat and pig resuscitation'. Pharmacology Research & Perspectives, 11 (5). [DOI]
Morris, Jodie L.; McEwen, Peter C.; Letson, Hayley L.; Dobson, Geoffrey P. (2023) 'Adenosine, Lidocaine and Magnesium (ALM) therapy modulates early sex-specific inflammatory and immune responses following experimental anterior cruciate ligament rupture and reconstruction'. Translational Medicine Communications, 8 . [DOI]
Dobson, Geoffrey P.; Morris, Jodie L.; Letson, Hayley L. (2023) 'Adenosine, lidocaine and Mg2+ update: teaching old drugs new tricks'. Frontiers in Medicine, 10 . [DOI]
Letson, Hayley L.; Biros, Erik; Morris, Jodie L.; Dobson, Geoffrey P. (2022) 'ALM fluid therapy shifts sympathetic hyperactivity to parasympathetic dominance in the rat model of non-compressible hemorrhagic shock'. Shock, 57 (2):264-273. [DOI]
Journal Publication
ResearchOnline@JCU
Morris, Jodie L.; Letson, Hayley L.; Biros, Erik; McEwen, Peter C.; Dobson, Geoffrey P. (2022) 'Female rats have a different healing phenotype than males after anterior cruciate ligament rupture with no intervention'. Frontiers in Medicine, 9 . [DOI]
Morris, Jodie; McEwen, Peter; Letson, Hayley; Dobson, Geoffrey (2022) 'Anterior Cruciate Ligament Reconstruction Surgery: Creating a Permissive Healing Phenotype in Military Personnel and Civilians for Faster Recovery'. Military Medicine, 187 (11-12):1310-1317. [DOI]
Engstrom, Nathan; Dobson, Geoffrey P.; Ng, Kevin; Lander, Krystle; Win, Kyi; Gupta, Anudeep; Letson, Hayley L. (2022) 'Validation of CalECG software for primary prevention heart failure patients: Reducing inter-observer measurement variability'. Journal of Electrocardiology, 74 :128-133. [DOI]
Journal Publication
ResearchOnline@JCU
Letson, Hayley L.; Morris, Jodie L.; Biros, Erik; Dobson, Geoffrey P. (2022) 'ALM induces cellular quiescence in the surgical margin 3 d following liver resection, hemorrhage, and shock'. Journal of Surgical Research, 275 :16-28. [DOI]
Journal Publication
ResearchOnline@JCU
Dobson, Geoffrey P.; Morris, Jodie L.; Letson, Hayley L. (2022) 'Why are bleeding trauma patients still dying? Towards a systems hypothesis of trauma'. Frontiers in Physiology, 13 . [DOI]
Engstrom, Nathan; Letson, Hayley Louise; Ng, Kevin; Dobson, Geoffrey Phillip (2022) 'Predicting arrhythmias in primary prevention heart failure patients: picking up the fragments'. Open Heart, 9 (2). [DOI]
Engstrom, Nathan; Dobson, Geoffrey; Kevin, Ng; Letson, Hayley (2022) 'Fragmented QRS is associated with ventricular arrhythmias in heart failure patients: a systematic review and meta-analysis'. Annals of Noninvasive Electrocardiology, 27 (1). [DOI]
Dobson, Geoffrey P.; Biros, Erik; Letson, Hayley L.; Morris, Jodie L. (2021) 'Living in a hostile world: inflammation, new drug development, and coronavirus'. Frontiers in Immunology, 11 . [DOI]
Morris, Jodie L.; Letson, Hayley L.; McEwen, Peter; Biros, Erik; Dlaska, Constantin; Hazratwala, Kaushik; Wilkinson, Matthew; Dobson, Geoffrey P. (2021) 'Comparison of intra‑articular administration of adenosine, lidocaine and magnesium solution and tranexamic acid for alleviating postoperative inflammation and joint fibrosis in an experimental model of knee arthroplasty'. Journal of Orthopaedic Surgery and Research, 16 . [DOI]
Letson, Hayley L.; Dobson, Geoffrey P. (2021) 'The role of nitric oxide in the efficacy of adenosine, lidocaine and magnesium (ALM) treatment of experimental hemorrhagic shock in rats'. Current Therapeutic Research, 95 . [DOI]
Dobson, Geoffrey P.; Morris, Jodie L.; Biros, Erik; Davenport, Lisa M.; Letson, Hayley L. (2021) 'Major surgery leads to a proinflammatory phenotype: differential gene expression following a laparotomy'. Annals Of Medicine And Surgery, 71 . [DOI]
Letson, Hayley; Dobson, Geoffrey (2021) 'Buprenorphine analgesia reduces survival with ALM resuscitation in a rat model of uncontrolled hemorrhage: concerns for trauma-related research'. Shock, 55 (3):379-387. [DOI]
Journal Publication
ResearchOnline@JCU
Conner, Jeff; Lammers, Daniel; Holtestaul, Torbjorg; Jones, Ian; Kuckelman, John; Letson, Hayley; Dobson, Geoffrey; Eckert, Matthew; Bingham, Jason (2021) 'Combatting ischemia reperfusion injury from resuscitative endovascular balloon occlusion of the aorta (REBOA) using adenosine, lidocaine and magnesium: a pilot study'. Journal of Trauma and Acute Care Surgery, 91 (6):995-1001. [DOI]
The role of matrix metalloproteinase-9 and its inhibitor TIMP-1 in burn injury: a systematic review
2021
Sharma, Chinmay; Dobson, Geoffrey P.; Davenport, Lisa; Morris, Jodie L.; Letson, Hayley L. (2021) 'The role of matrix metalloproteinase-9 and its inhibitor TIMP-1 in burn injury: a systematic review'. International Journal of Burns and Trauma, 11 (4):275-288.
Morris, Jodie L.; Letson, Hayley L.; McEwen, Peter; Biros, Erik; Dlaska, Constantin; Hazratwala, Kaushik; Wilkinson, Matthew; Dobson, Geoffrey P. (2021) 'Intra-articular Adenosine, Lidocaine and Magnesium (ALM) solution decreases postoperative joint fibrosis in an experimental knee implant model'. Translational Medicine Communications, 6 . [DOI]
Letson, Hayley L.; Granfeldt, Asger; Jensen, Thomas H.; Mattson, Thomas H.; Dobson, Geoffrey P. (2020) 'Adenosine, lidocaine, and magnesium support a high flow, hypotensive, vasodilatory state with improved oxygen delivery and cerebral protection in a pig model of noncompressible hemorrhage'. Journal of Surgical Research, 253 :127-138. [DOI]
Journal Publication
ResearchOnline@JCU
Elsiwy, Yassin; Symonds, Tristan; Doma, Kenji; Hazratwala, Kaushik; Wilkinson, Matthew; Letson, Hayley (2020) 'Pre-operative clinical predictors for cardiology referral prior to total joint arthroplasty: the 'asymptomatic' patient'. Journal of Orthopaedic Surgery and Research, 15 . [DOI]
Dobson, Geoffrey P.; Morris, Jodie L.; Davenport, Lisa M.; Letson, Hayley L. (2020) 'Traumatic-induced coagulopathy as a systems failure: a new window into hemostasis'. Seminars in Thrombosis and Hemostasis, 46 (2):199-214. [DOI]
Journal Publication
ResearchOnline@JCU
Engstrom, Nathan; Dobson, Geoffrey; Ng, Kevin; Letson, Hayley (2020) 'Primary prevention implantable cardiac defibrillators: a Townsville district perspective'. Frontiers in Cardiovascular Medicine, 7 . [DOI]
Dobson, Geoffrey P.; Letson, Hayley L. (2020) 'Far forward gaps in hemorrhagic shock and prolonged field care: an update of ALM fluid therapy for field use'. Journal of Special Operations Medicine, 20 (3):128-134.
Journal Publication
ResearchOnline@JCU
Tobin, Joshua M.; Gavitt, Brian J.; Nomellini, Vanessa; Dobson, Geoffrey P.; Letson, Hayley L.; Shackelford, Stacy A. (2020) 'Immunotherapeutic options for inflammation in trauma'. Journal of Trauma and Acute Care Surgery, 89 (25):S77-S82. [DOI]
Journal Publication
ResearchOnline@JCU
Morris, Jodie L.; Letson, Hayley L.; Elliott, Lisa; Grant, Andrea L.; Wilkinson, Matthew; Hazratwala, Kaushik; McEwen, Peter (2019) 'Evaluation of bacteriophage as an adjunct therapy for treatment of peri-prosthetic joint infection caused by Staphylococcus aureus'. PLoS ONE, 14 (12). [DOI]
Conventional and specific-pathogen free rats respond differently to anesthesia and surgical trauma
2019
Letson, Hayley L.; Morris, Jodie; Biros, Erik; Dobson, Geoffrey P. (2019) 'Conventional and specific-pathogen free rats respond differently to anesthesia and surgical trauma'. Scientific Reports, 9 . [DOI]
Morris, Jodie L.; Letson, Hayley L.; Gillman, Rhys; Hazratwala, Kaushik; Wilkinson, Matthew; McEwen, Peter; Dobson, Geoffrey P. (2019) 'The CNS theory of osteoarthritis: opportunities beyond the joint'. Seminars in Arthritis and Rheumatism, 49 (3):331-336. [DOI]
Journal Publication
ResearchOnline@JCU
McCutchan, Andrew; Dobson, Geoffrey P.; Stewart, Natalie; Letson, Hayley L.; Grant, Andrea L.; Jovanovic, Ivana-Aleksandra; Hazratwala, Kaushik; Wilkinson, Matthew; McEwen, Peter; Morris, Jodie (2019) 'Absence of cytotoxic and inflammatory effects following in vitro exposure of chondrogenically-differentiated human mesenchymal stem cells to adenosine, lidocaine and Mg2+ solution'. Journal of Experimental Orthopaedics, 6 . [DOI]
Davenport, Lisa; Dobson, Geoffrey; Letson, Hayley (2019) 'The role of invasive monitoring in the resuscitation of major burns: a systematic review and meta-analysis'. International Journal of Burns and Trauma, 9 (2):28-40.
Letson, Hayley Louise; Morris, Jodie Louise; Biros, Erik; Dobson, Geoffrey Phillip (2019) 'Adenosine, lidocaine, and Mg2+ fluid therapy leads to 72-hour survival after hemorrhagic shock'. Journal of Trauma and Acute Care Surgery, 87 (3):606-613. [DOI]
Journal Publication
ResearchOnline@JCU
Elsiwy, Yassin; Jovanovic, Ivana; Doma, Kenji; Hazratwala, Kaushik; Letson, Hayley (2019) 'Risk factors associated with cardiac complication after total joint arthroplasty of the hip and knee: a systematic review'. Journal of Orthopaedic Surgery and Research, 14 . [DOI]
Morris, Jodie L.; Letson, Hayley L.; Grant, Andrea; Wilkinson, Matthew; Hazratwala, Kaushik; McEwen, Peter (2019) 'Experimental model of peri-prosthetic infection of the knee caused by Staphylococcus aureus using biomaterials representative of modern TKA'. Biology Open, 8 . [DOI]
Davenport, Lisa; Dobson, Geoffrey; Letson, Hayley (2019) 'A new model for standardising and treating thermal injury in the rat'. MethodsX, 6 :2021-2027. [DOI]
Grant, Andrea L.; Letson, Hayley L.; Morris, Jodie L.; McEwen, Peter; Hazratwala, Kaushik; Wilkinson, Matthew; Dobson, Geoffrey P. (2018) 'Tranexamic acid is associated with selective increase in inflammatory markers following total knee arthroplasty (TKA): a pilot study'. Journal of Orthopaedic Surgery and Research, 13 . [DOI]
Letson, Hayley L.; Dobson, Geoffrey P. (2018) 'Adenosine, lidocaine, and Mg2+ (ALM) resuscitation fluid protects against experimental traumatic brain injury'. Journal of Trauma and Acute Care Surgery, 84 (6):908-916. [DOI]
Journal Publication
ResearchOnline@JCU
Letson, Hayley Louise; Dobson, Geoffrey Phillip (2018) '7.5% NaCl resuscitation leads to abnormal clot fibrinolysis after severe hemorrhagic shock and its correction with 7.5% NaCl adenosine, lidocaine, and Mg2+'. Journal of Emergencies, Trauma, and Shock, 11 (1):15-24. [DOI]
Dobson, G.P.; Letson, H.L.; Grant, A.; McEwen, P.; Hazratwala, K.; Wilkinson, M.; Morris, J.L. (2018) 'Defining the osteoarthritis patient: back to the future'. Osteoarthritis and Cartilage, 26 (8):1003-1007. [DOI]
Davenport, Lisa; Letson, Hayley L.; Dobson, Geoffrey P. (2017) 'Immune-inflammatory activation after a single laparotomy in a rat model: effect of adenosine, lidocaine and Mg2+ infusion to dampen the stress response'. Innate Immunity, 23 (5):482-494. [DOI]
Journal Publication
ResearchOnline@JCU
Letson, Hayley; Dobson, Geoffrey (2017) 'Adenosine, lidocaine and Mg²⁺ (ALM)fluid therapy attenuates systemic inflammation, platelet dysfunction and coagulopathy after non-compressible truncal hemorrhage'. PLoS ONE, 12 (11). [DOI]
Dobson, Geoffrey P.; Arsyad, Aryadi; Letson, Hayley (2017) 'The adenosine hypothesis revisited: modulation of coupling between myocardial perfusion and arterial compliance'. Frontiers in Physiology, 8 . [DOI]
Griffin, Maddison J.; Letson, Hayley L.; Dobson, Geoffrey P. (2017) 'Buprenorphine analgesia leads to coagulopathy and increased plasma fibrinogen in healthy rats: implications for small animal research'. Shock, 48 (1):78-84. [DOI]
Journal Publication
ResearchOnline@JCU
Letson, Hayley; Dobson, Geoffrey (2017) '3% NaCl adenosine, lidocaine, Mg2+ (ALM) bolus and 4 hours drip infusion reduces noncompressible hemorrhage by 60% in a rat model'. Journal of Trauma and Acute Care Surgery, 82 (6):1063-1072. [DOI]
Journal Publication
ResearchOnline@JCU
Sharma, Rajiv; Letson, Hayley L.; Smith, Samuel; Dobson, Geoffrey P. (2017) 'Tranexamic acid leads to paradoxical coagulation changes during cardiac surgery: a pilot rotational thromboelastometry study'. Journal of Surgical Research, 217 :100-112. [DOI]
Journal Publication
ResearchOnline@JCU
Dobson, Geoffrey Phillip; Letson, Hayley Louise (2016) 'Adenosine, lidocaine, and Mg2+ (ALM): from cardiac surgery to combat casualty care - teaching old drugs new tricks'. Journal of Trauma and Acute Care Surgery, 80 (1):135-145. [DOI]
Journal Publication
ResearchOnline@JCU
Letson, Hayley L.; Dobson, Geoffrey (2016) 'Differential contributions of platelets and fibrinogen to early coagulopathy in a rat model of hemorrhagic shock'. Thrombosis Research, 141 :58-65. [DOI]
Journal Publication
ResearchOnline@JCU
Griffin, Maddison Jade; Letson, Hayley Louise; Dobson, Geoffrey Phillip (2016) 'Small-volume adenosine, lidocaine, and Mg2+ 4-hour infusion leads to 88% survival after 6 Days of experimental sepsis in the rat without antibiotics'. Clinical and Vaccine Immunology, 23 (11):863-872. [DOI]
Journal Publication
ResearchOnline@JCU
Dobson, Geoffrey P.; Letson, Hayley L.; Sharma, Rajiv; Sheppard, Forest R.; Cap, Andrew P. (2015) 'Mechanisms of early trauma-induced coagulopathy: the clot thickens or not?'. Journal of Trauma and Acute Care Surgery, 79 (2):301-309. [DOI]
Journal Publication
ResearchOnline@JCU
Letson, Hayley L.; Dobson, Geoffrey P. (2015) 'Correction of acute traumatic coagulopathy with small-volume 7.5% NaCl adenosine, lidocaine, and Mg2+ occurs within 5 minutes: a ROTEM analysis'. Journal of trauma and acute care surgery, 78 (4):773-783. [DOI]
Journal Publication
ResearchOnline@JCU
Dobson, Geoffrey P.; Letson, H.L.; Tadaki, D. (2014) 'The Bellamy challenge: it's about time'. Journal of the Royal Army Medical Corps, 160 :9-15. [DOI]
Journal Publication
ResearchOnline@JCU
Granfeldt, Asger; Letson, Hayley L.; Hyldebrandt, Janus A.; Wang, Edward R.; Salcedo, Pablo A.; Nielsen, Torben K.; Tønnesen, Else; Vinten-Johansen, Jakob; Dobson, Geoffrey P. (2014) 'Small-volume 7.5% NaCI adenosine lidocaine, and Mg2+ has multiple benefits during hypotensive and blood resuscitation in the pig following severe blood loss: rat to pig translation'. Critical Care Medicine, 42 (5):e329-e344. [DOI]
Journal Publication
ResearchOnline@JCU
Griffin, Maddison J.; Letson, Hayley L.; Dobson, Geoffrey P. (2014) 'Adenosine, lidocaine and Mg^2+ (ALM) induces a reversible hypotensive state, reduces lung edema and prevents coagulopathy in the rat model of polymicrobial sepsis'. Journal of trauma and acute care surgery, 77 (3):471-478. [DOI]
Journal Publication
ResearchOnline@JCU
Granfeldt, Asger; Letson, Hayley L.; Dobson, Geoffrey P.; Shi , Wei; Vinten-Johansen, Jakob; Tønnesen, Else (2014) 'Adenosine, lidocaine and Mg^2+ improves cardiac and pulmonary function, induces reversible hypotension and exerts anti-inflammatory effects in an endotoxemic porcine model'. Critical Care Medicine, 18 (6):1-19. [DOI]
Djabir, Yulia; Letson, Hayley L.; Dobson, Geoffrey P. (2013) 'Adenosine, lidocaine, and Mg²⁺ (ALM™) increases survival and corrects coagulopathy after eight-minute asphyxial cardiac arrest in the rat'. Shock, 40 (3):222-232. [DOI]
Journal Publication
ResearchOnline@JCU
Letson, Hayley L.; Pecheniuk, Natalie M.; Mhango, Lebo P.; Dobson, Geoffrey P. (2012) 'Reversal of acute coagulopathy during hypotensive resuscitation using small-volume 7.5% NaCl adenocaine and Mg2+ in the rat model of severe hemorrhagic shock'. Critical Care Medicine, 40 (8):2417-2422. [DOI]
Journal Publication
ResearchOnline@JCU
Letson, Hayley L.; Dobson, Geoffrey P. (2011) 'Unexpected 100% survival following 60% blood loss using small-volume 7.5% NaCl with Adenocaine and mg2+ in the rat model of extreme hemorrhagic shock'. Shock, 36 (6):586-594. [DOI]
Journal Publication
ResearchOnline@JCU
Letson, Hayley L.; Dobson, Geoffrey P. (2011) 'Small volume 7.5% NaCl With 6% dextran-70 or 6% and 10% hetastarch are associated with arrhythmias and death after 60 minutes of severe hemorrhagic shock in the rat in vivo'. Journal of Trauma, 70 (6):1444-1452. [DOI]
Journal Publication
ResearchOnline@JCU
Letson, Hayley L.; Dobson, Geoffrey P. (2011) 'Ultra-small intravenous bolus of 7.5% NaCl/Mg2+ with adenosine and lidocaine improves early resuscitation outcome in the rat after severe hemorrhagic shock in vivo'. Journal of Trauma, 71 (3):708-719. [DOI]
Journal Publication
ResearchOnline@JCU
Dobson, Geoffrey P.; Morris, Jodie L.; Letson, Hayley L. (2024) 'Transforming research to improve therapies for trauma in the twenty‑first century: an alternative perspective' Critical Care, 28 . [DOI]
Blanco, Gonzalo; Morris, Edward; Morris, Jodie L.; Letson, Hayley L.; Susheel, Suvarna; Puiggros, Anna; Espinet, Blanca; Chiorazzi, Nicholas; Dobson, Geoffrey P. (2024) 'Spontaneous Regression Accompanied by Concomitant Immune Alterations in a Patient with Chronic Lymphocytic Leukemia' Annals of Case Reports, 9 . [DOI]
Engstrom, Nathan; Letson, Hayley; Ng, Kevin; Dobson, Geoffrey (2024) 'Ventriculo-arterial (VA) coupling and fQRS as new selection criteria for primary prevention ICD placement' Intensive Care Medicine Experimental, 12 . [DOI]
Dobson, Geoffrey; Gibbs, Clinton; Poole, Lee; Butson, Ben; Lawton, Luke D.; Morris, Jodie L.; Letson, Hayley (2022) 'Trauma care in the tropics: addressing gaps in treating injury in rural and remote Australia' Rural and Remote Health, 22 . [DOI]
Dobson, Geoffrey P.; Morris, Jodie L.; Letson, Hayley L. (2022) 'Immune dysfunction following severe trauma: A systems failure from the central nervous system to mitochondria' Frontiers in Medicine, 9 . [DOI]
Dobson, Geoffrey P.; Morris, Jodie L.; Biros, Erik; Letson, Hayley L. (2020) 'Specific pathogen-free animals for civilian and military trauma: a cautionary note in the translation of new drug therapies' Shock, 54 (2) :232-236. [DOI]
Journal Contribution
ResearchOnline@JCU
Letson, Hayley L.; Dobson, Geoffrey P. (2020) 'Buprenorphine analgesia: new adverse effects emerge' Shock, 54 (2) :272-272. [DOI]
Journal Contribution
ResearchOnline@JCU
Letson, Hayley L.; Dobson, Geoffrey P. (2019) 'Truth behind the appearances: translating new drug therapies to humans' Journal of Trauma and Acute Care Surgery, 88 (2) :e105-e105. [DOI]
Journal Contribution
ResearchOnline@JCU
Letson, Hayley L.; Dobson, Geoffrey Phillip (2019) 'Response to letter to the editor' Journal of Trauma and Acute Care Surgery, 86 (2) :376-376. [DOI]
Journal Contribution
ResearchOnline@JCU
Dobson, Geoffrey P.; Letson, Hayley L.; Biros, Erik; Morris, Jodie (2019) 'Specific pathogen-free (SPF) animal status as a variable in biomedical research: have we come full circle?' EBioMedicine, 41 :42-43. [DOI]
Dobson, Geoffrey P.; Doma, Kenji; Letson, Hayley L. (2018) 'Clinical relevance of a p value: Does tranexamic acid save lives after trauma or postpartum hemorrhage?' Journal of Trauma and Acute Care Surgery, 84 (3) :532-536. [DOI]
Journal Contribution
ResearchOnline@JCU
Letson, Hayley L.; Dobson, Geoffrey P. (2017) 'Tranexamic acid for post-partum haemorrhage in the WOMAN trial' Lancet, 390 (10102) :1581-1582. [DOI]
Journal Contribution
ResearchOnline@JCU
Griffin, Maddison; Letson, Hayley L.; Dobson, Geoffrey P. (2014) 'Optimization of the rodent model of polymicrobial sepsis' International Immunopharmacology, 19 (2) :405-405. [DOI]
Journal Contribution
ResearchOnline@JCU
Granfeldt, Asger; Letson, Hayley L,; Dobson, Geoffrey P.; Shi, WeiWei; Vinten-Johansen, Jakob; Tønnesen, Else (2013) 'Cardioprotective and anti-inflammatory effects of treatment with adenocaine/mg2+ in a porcine model of endotoxemia' Circulation, 128 (122) .
Letson, Hayley L.; Dobson, Geoffrey P. (2013) 'Acute coagulopathy of trauma in the rat' Shock, 40 (1) :74-74. [DOI]
Journal Contribution
ResearchOnline@JCU
Letson, Hayley L.; Pecheniuk, Natalie M.; Mhango, Lebo P.; Dobson, Geoffrey P. (2011) 'Reversal of acute coagulopathy using small-volume 7.5% NaCl with adenocaine and Mg2+ resuscitation in a rat model of severe hemorrhagic shock' Circulation, 124 (21 Supplement) :1-1.
Journal Contribution
ResearchOnline@JCU
Letson, Hayley L.; Dobson, Geoffrey P. (2010) '7.5% NaCl with adenosine, lidocaine and Mg2+ (ALM) improves hypotensive resuscitation in the pressure-controlled rat model of severe hemorrhagic shock' Circulation, 122 (21) .
Letson, Hayley L.; Dobson, Geoffrey P. (2010) 'Surviving 60% blood loss using 7.5% NaCl with adenosine, lidocaine and magnesium (ALM) in the rat model of battlefield hemorrhagic shock' Circulation, 122 (Supplement 21) .
Granfeldt, Asger; Letson, Hayley L.; Hyldebrandt, Janus A; Wang, Edward R.; Salcedo, Pablo A.; Nielsen, Torben K.; Tønnesen, Else ; Vinten-Johansen, Jakob ; Dobson, Geoffrey P. (2012) Resuscitation Science Symposium Small-volume 7.5% NaCl adenocaine/Mg2+ preserves cardiac function during hypotensive resuscitation in the pig following severe hemorrhagic shock Los Angeles, California, USA, .
Letson, Hayley I.; Granfeldt, Asger; Hyldebrandt, Janus; Wang, Edward R.; Salcedo , Pablo A.; Nielsen, Torben K.; Tønnesen, Else K.; Vinten-Johansen, Jakob ; Dobson, Geoffrey P. (2012) Resuscitation Science Symposium Abstract 177: Rat to pig translation: small-volume 7.5% NaCl adenocaine/Mg2+ has multiple physiological benefits during hypotensive and blood resuscitation in the porcine model of severe hemorrhagic shock
Los Angeles, California, USA, .