Acute coagulopathy of trauma in the rat

Letson, Hayley L.;Dobson, Geoffrey P.

Abstract

[Extract] Darlinglon and colleagues (I) at the US Army Institute of Surgical Research are to be congratulated in attempting to develop a rat model of acute coagulopalhy resulting from poly trauma and hemorrhage. As the authors point out, coagulopathy occurs early in hemorrhagic trauma and is a major contributor to mortality and morbidity. Coagulopathic bleeding was first reported in the Vietnam War (2) and rediscovered some 40 years later by Brohi (3). Several large trials have shown that 24% to 36% of severely injured patients have acute traumatic coagulopathy on admission to the emergency department (mean arrival lime, 75 min), and it was associated with a 4-fold increase in mortality (3-5).

Journal

Shock

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1540-0514

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Lippincott Williams & Wilkins

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DOI

10.1097/SHK.0b013e318296e18e