Optimization of the rodent model of polymicrobial sepsis

Griffin, Maddison;Letson, Hayley L.;Dobson, Geoffrey P.

Abstract

[Extract] Severe sepsis activates the systemic inflammatory and coagulation systems and is a leading cause of global morbidity and mortality claiming over 8 million lives every year [1]. New therapies are urgently required to slow or alleviate the progression of the infection. We congratulate Wang and colleagues [2] on their contribution to seek improved drug therapies to treat sepsis. They showed that the serine protease inhibitor, Ulinastatin, may be an effective candidate to increase survival, attenuate inflammation and prevent systemic disorder and organ dysfunction following sepsis.

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International Immunopharmacology

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1878-1705

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Elsevier

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DOI

10.1016/j.intimp.2014.01.016