Truth behind the appearances: translating new drug therapies to humans

Journal Contribution ResearchOnline@JCU
Letson, Hayley L.;Dobson, Geoffrey P.
Hayley Letson
Abstract

[Extract] We read with interest the recent study of How et al.1 evaluating adenosine, lidocaine, and magnesium (ALM) therapy in a porcine model of prolonged hemorrhagic shock. The main finding of the study was that ALM was inferior to current Tactical Combat Casualty Care (TCCC) resuscitation in the pig model of controlled bleeding (44% to 60% blood volume loss) with mild hypothermia (36°C).1 This is in direct contrast to our four translational resuscitation studies from rats to pigs since 2012 showing profound benefit after controlled bleeding with up to 75% blood loss,2 endotoxemia,3 and, more recently, after noncompressible hepatic bleeding.4

Journal

Journal of Trauma and Acute Care Surgery

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N/A

Volume

88

ISBN/ISSN

2163-0763

Edition

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Issue

2

Pages Count

1

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Publisher

Lippincott, Williams & Wilkins

Publisher Url

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Publisher Location

N/A

Publish Date

N/A

Url

N/A

Date

N/A

EISSN

N/A

DOI

10.1097/TA.0000000000002507