Projects 16
Publications 30
Awards 26

Contact Details

A/prof

Biography

I completed both my undergraduate and postgraduate studies at the University of Portsmouth (UK) and received my PhD in molecular biology in 2008. I moved to Australia for a 1 year position in the JCU vascular biology unit as a Post-doctoral researcher (2009). I was subsequently offered a 3 year position at Bristol University (UK) as a Post-doctoral Research Associate (2010-2012). During my time at Bristol University I started teaching into their undergraduate courses and found that I really enjoyed this aspect of academia. I moved back to Australia in 2013 as an anatomy lecturer at JCU and was promoted to Senior Lecturer in 2018. 

I am an enthusiastic and engaging anatomist with over a decade of experience in educating undergraduate students in Allied Health, Medicine, Pharmacy and Biomedicine. I have received a Teaching Citation for my outstanding contribution to student learning, which was entered into the Australian Awards for University Teaching (AAUT) and I have been awarded 3 Inclusive Practice awardsMy teaching has been strongly influenced by transitional pedagogy, focusing on the transition of students into university life. My use innovative online and blended learning resources has been recognised by the university and has showcased as exemplar on a number of occasions. My passion for teaching extends beyond the university and into the local community, where I teach anatomy and run workshops at local schools and events. 

My research focuses on stroke a major worldwide health concern with devasting effects for patients, especially in Northern Queensland, due to limited specialist care and remote locations. To learn more about why I am interested in this area of research you can watch my TEDx Cairns talk HERE: https://www.youtube.com/watch?v=4kz-bWmz9KI 

I am also interested in the Scholarship of Teaching and Learning (SoTL) in particular the development of technology and its use within the Universal Design for Learning (UDL) framework. 

For more information on me and the Anatomy Team please see our JCUAnatomy Facebook Page ðŸ˜Š


Research

Research Interests

Stroke Research 

My research is focused on stroke and its pathophysiology. Stroke is a condition where there is interrupted blood flow to the brain, this can be temporary or permanent but the consequences can be devasting. A major component factor in the clinical outcome for the patient is the time that it takes to treat them and essentially if possible established blood flow to the area of the bran that have been affected. Early detection can save lives and we are looking about potential biomarkers of stroke. Another important area of research is a more targeted approach with treatment, focusing on the brain tissue which can be recovered (penumbra). 

Scholarship of Teaching and Learning (SoTL) 

Technology enabled learning is an important component of teaching and trialing new and innovative technologies is another area of research that interests me. Anatomy is a subject which is very content heavy and implementing new and exciting technologies can assist students with learning the material through increased engagement. 

Projects

Teaching

Teaching Interests

Anatomy is a fascinating area of science and is a core component of many disciplines. I love teaching anatomy and exploring new and exciting ways to deliver the content.  Effective teaching is inspiring, motivating and research-informed, this is one of the Core Principles from JCU's Learning and Teaching Policy, which I incorporate into all of my teaching. Successful teaching requires careful consideration of the levels of knowledge required, methods of delivery, and approaches to student support. In order to accommodate a very diverse range of learning styles and abilities, I have developed a suite of blended learning tools and resources that can be adapted for each individual cohort. I also work closely with subject and course coordinators and other teaching staff to ensure the relevant content is delivered at the appropriate level always keeping in mind that the students are at the heart the university. 

I am the coordinator of the MBBS6 Research Activity, which is an essential component of the MBBS program strengthening research in the medical curriculum and supporting students with their research. This activity requires >200 students to individually plan a research project (Task 1) from which they receive feedback and then they submit a research proposal (Task 2). 


Research Advisor Accreditation

Advisor Type

Primary

Research Advisor Accreditation

Role

Chair; Independent Academic


Taught Modules

Current JCU Research Students

Investigating the clinical utility of MYD88 (L265P) mutation testing during the workup of Waldenström Macroglobulinemia within Australia
Master of Philosophy (Medical, Molecular and Veterinary Sciences)
An Anatomical Approach to the Study of Osteoporosis and Bone Health in Past and Present Human Remains
Doctor of Philosophy (Health)

Completed Honours and External Research Students

Can intraoperative imaging of epicardial adipose tissue be useful in estimating intramyocardial fibrosis in patients undergoing open heart surgery?
HONOURS
The prevalence of low anterior resection syndrome at a Regional Australian Institute
OTHER
The potential benefit of intensive low-density lipoprotein cholesterol lowering in people with peripheral artery disease
HONOURS
Circulating microRNAs as biomarkers for acute ischAemic stroke: AN ANALYSIS OF THE LITERATURE
RESEARCH_MASTERS

Teaching Grants

Available Projects

Activities

Employment

Education

Awards

Associations

Outreach

Media

Committees

Output

Collins, Andrew; Gutièrrez-Mecinas, María; Trollope, Alexandra F.; Reul, Johannes M.H.M. (2012) Epigenetics of stress. Sharjah, Unites Arab Emirates: [DOI]
Other Publication ResearchOnline@JCU
Moxon, Joseph V.; Pretorius, Cornea; Trollope, Alexandra F.; Mittal, Parul; Klingler-Hoffmann, Manuela; Hoffmann, Peter; Golledge, Jonathan (2024) 'A systematic review and in silico analysis of studies investigating the ischaemic penumbra proteome in animal models of experimental stroke'. Journal of Cerebral Blood Flow & Metabolism, 44 (10):1709-1722. [DOI]
Journal Publication Open Access ResearchOnline@JCU
Krishnan, Anirudh; Sharma, Harman; Yuan, Daniel; Trollope, Alex; Chilton, Lisa (2022) 'The Role of Epicardial Adipose Tissue in the Development of Atrial Fibrillation, Coronary Artery Disease and Chronic Heart Failure in the Context of Obesity and Type 2 Diabetes Mellitus: A Narrative Review'. Journal of Cardiovascular Development and Disease, 9 . [DOI]
Journal Publication Open Access ResearchOnline@JCU
Nastasi, Domenico R.; Moxon, Joseph V.; Norman, Richard; Trollope, Alex F.; Rowbotham, Sophie; Quigley, Frank; Jenkins, Jason; Golledge, Jonathan (2021) 'The cost-effectiveness of intensive low-density lipoprotein cholesterol lowering in people with peripheral artery disease'. Journal of Vascular Surgery, 73 (4):1396-1403.e3. [DOI]
Journal Publication ResearchOnline@JCU
Krishnan, Anirudh; Chilton, Emily; Raman, Jaishankar; Saxena, Pankaj; McFarlane, Craig; Trollope, Alexandra F.; Kinobe, Robert; Chilton, Lisa (2021) 'Are interactions between epicardial adipose tissue, cardiac fibroblasts and cardiac myocytes instrumental in atrial fibrosis and atrial fibrillation?'. Cells, 10 (9). [DOI]
Journal Publication Open Access ResearchOnline@JCU
Krishna, Smriti Murali; Li, Jiaze; Wang, Yutang; Moran, Corey S.; Trollope, Alexandra; Mohamed Omer, Safraz; Huynh, Pacific; Jose, Roby; Biros, Erik; Ma, Jianxing; Golledge, Jonathan (2021) 'Kallistatin limits abdominal aortic aneurysm by attenuating generation of reactive oxygen species and apoptosis'. Scientific Reports, 11 . [DOI]
Journal Publication Open Access ResearchOnline@JCU
Moxon, Joseph V.; Trollope, Alex F.; Dewdney, Brittany; de Hollander, Catherine; Nastasi, Domenico R.; Maguire, Jane M.; Golledge, Jonathan (2019) 'The effect of angiopoietin-1 upregulation on the outcome of acute ischaemic stroke in rodent models: a meta-analysis'. Journal of Cerebral Blood Flow & Metabolism, 39 (12):2343-2354. [DOI]
Journal Publication Open Access ResearchOnline@JCU
Nastasi, Domenico R.; Smith, Justin R.; Moxon, Joseph V.; Trollope, Alex; Golledge, Jonathan (2018) 'Prescription of pharmacotherapy and the incidence of stroke in patients with symptoms of peripheral artery disease'. Stroke, 49 (12). [DOI]
Journal Publication Open Access ResearchOnline@JCU
Croese, Alexander D.; Zubair, Omar N.; Lonie, James; Trollope, Alexandra F.; Vangaveti, Venkat N.; Mushaya, Chrispen; Ho, Yik-Hong (2018) 'Prevalence of low anterior resection syndrome at a regional Australian centre'. ANZ Journal of Surgery, 88 (12):E813-E817. [DOI]
Journal Publication ResearchOnline@JCU
Dewdney, Brittany Alexandra; Trollope, Alex; Moxon, Joseph; Thomas Manapurathe, Diana; Biros, Erik; Golledge, Jonathan (2018) 'Circulating microRNAs as biomarkers for acute ischemic stroke: a systematic review'. Journal of Stroke and Cerebrovascular Diseases, 27 (3):522-530. [DOI]
Journal Publication ResearchOnline@JCU
Croese, Alexander D.; Lonie, James M.; Trollope, Alexandra F.; Vangaveti, Venkat N.; Ho, Yik-Hong (2018) 'A meta-analysis of the prevalence of Low Anterior Resection Syndrome and systematic review of risk factors'. International Journal of Surgery, 56 :234-241. [DOI]
Journal Publication Open Access ResearchOnline@JCU
Trollope, Alex; Mifsud, Karen; Saunderson, Emily; Reul, Johannes (2017) 'Molecular and epigenetic mechanisms underlying cognitive and adaptive responses to stress'. Epigenomes, 1 (3). [DOI]
Journal Publication ResearchOnline@JCU
Mifsud, Karen R.; Saunderson, Emily A.; Spiers, Helen; Carter, Sylvia D.; Trollope, Alexandra F.; Mill, Jonathon; Reul, Johannes M.H.M. (2016) 'Rapid down-regulation of glucocorticoid gene expression in the dentate Gyrus after acute stress in vivo: role of DNA methylation and microRNA activity'. Neuroendocrinology, 104 (2):157-169. [DOI]
Journal Publication Open Access ResearchOnline@JCU
Yu, Hongyou; Moran, Corey S.; Trollope, Alexandra F.; Woodward, Lynn; Kinobe, Robert; Rush, Catherine M.; Golledge, Jonathan (2016) 'Angiopoietin-2 attenuates angiotensin II-induced aortic aneurysm and atherosclerosis in apolipoprotein E-deficient mice'. Scientific Reports, 6 :1-11. [DOI]
Journal Publication Open Access ResearchOnline@JCU
Saunderson, Emily A.; Spiers, Helen; Mifsud, Karen R.; Gutierrez-Mecinas, Maria; Trollope, Alexandra F.; Shaikh, Abeera; Mill, Jonathan; Reul, Johannes M.H.M. (2016) 'Stress-induced gene expression and behavior are controlled by DNA methylation and methyl donor availability in the dentate gyrus'. Proceedings of the National Academy of Sciences of the United States of America, 113 (17):4830-4835. [DOI]
Journal Publication Open Access ResearchOnline@JCU
Krishna, Smriti Murali; Trollope, Alexendra Fay; Golledge, Jonathan (2015) 'The relevance of epigenetics to occlusive cerebral and peripheral arterial disease'. Clinical Science, 128 (9):537-558. [DOI]
Journal Publication Open Access ResearchOnline@JCU
Trollope, Alexandra F.; Gutirrèz-Mecinas, María; Mifsud, Karen R.; Collins, Andrew; Saunderson, Emily A.; Reul, Johannes M.H.M. (2012) 'Stress, epigenetic control of gene expression and memory formation'. Experimental Neurology, 233 (1):3-11. [DOI]
Journal Publication Open Access ResearchOnline@JCU
Mifsud, Karen R.; Gutirrèz-Mecinas, María; Trollope, Alexandra F.; Collins, Andrew; Saunderson, Emily A.; Reul, Johannes M.H.M. (2011) 'Epigenetic mechanisms in stress and adaptation'. Brain, Behavior, and Immunity, 25 (7):1305-1315. [DOI]
Journal Publication Open Access ResearchOnline@JCU
Trollope, Alexandra F.; Golledge, Jonathan (2011) 'Angiopoietins, abdominal aortic aneurysm and atherosclerosis'. Atherosclerosis, 214 (2):237-243. [DOI]
Journal Publication ResearchOnline@JCU
Trollope, Alexandra; Moxon, Joseph V.; Moran, Corey S.; Golledge, Jonathan (2011) 'Animal models of abdominal aortic aneurysm and their role in furthering management of human disease'. Cardiovascular Research, 20 (2):114-123. [DOI]
Journal Publication ResearchOnline@JCU
Gutirrèz-Mecinas, María; Trollope, Alexandra F.; Collins, Andrew; Morfett, Hazel; Hesketh, Shirley A.; Kersanté, Flavie; Reul, Johannes M.H.M. (2011) 'Long-lasting behavioral responses to stress involve a direct interaction of glucocorticoid receptors with ERK1/2–MSK1–Elk-1 signaling'. Proceedings of the National Academy of Sciences of the United States of America, 108 (33):13806-13811. [DOI]
Journal Publication ResearchOnline@JCU
Trollope, Alexandra F.; Sapojnikova, Nelly; Thorne, Alan W.; Crane-Robinson, Colyn ; Myers, Fiona A. (2010) 'Linker histone subtypes are not generalized gene repressors'. Biochimica et Biophysica Acta, 1799 (9):642-652. [DOI]
Journal Publication ResearchOnline@JCU
Rush, Catherine; Nyara, Moses; Moxon, Joseph V.; Trollope, Alexandra; Cullen, Bradford; Golledge, Jonathan (2009) 'Whole genome expression analysis within the angiotensin II-apolipoprotein E deficient mouse model of abdominal aortic aneurysm'. BMC Genomics, 10 (298). [DOI]
Journal Publication ResearchOnline@JCU
Abu-Daya, Anita; Steer, Wendy M.; Trollope, Alexandra F.; Friedeberg, Christine E.; Patient, Roger K.; Thorne, Alan W.; Guille, Matthew J. (2005) 'Zygotic nucleosome assembly protein-like 1 has a specific, non-cell autonomous role in hematopoiesis'. Blood, 106 (2):514-520. [DOI]
Journal Publication ResearchOnline@JCU
Trollope, A.; Domett, K.; Woolley, T.; Gavan, A. (2021) 'Evaluating the effectiveness of an online interactive histology resource' Clinical Anatomy, 34 (8) :e15-e15.
Journal Contribution ResearchOnline@JCU
Anscomb, H.; Harris, R.; Domett, K.; Trollope, A. (2016) 'Prepared to study: resources designed to aid student studies in human cadaveric anatomy' Clinical Anatomy, 29 (2) :217-217. [DOI]
Journal Contribution Open Access ResearchOnline@JCU
Saunderson, E.A.; Trollope, A.F.; Guierrez-Mecinas, M.; Shaikh, A.A. ; Spiers , H.; Mill, J .; Reul, J.M.H.M. (2013) 'S-Adenosyl-methionine impairs forced swimming-induced behavioural immobility by inhibiting gene expression in dentate gyrus neurons' European Neuropsychopharmacology, 23 (Supplement 1) :S63-S64. [DOI]
Journal Contribution ResearchOnline@JCU
Mifsud, K.R.; Gutierrez-Mecinas, M.; Collins , A.; Trollope, A.F.; Carter, S.D.; Reul, J.M.H.M. (2012) 'Forced swim stress enhances the survival of new dentate gyrus neurons in rat through a glucocorticoid receptor-dependent mechanism' European Neuropsychopharmacology, 22 (Supplement 1) :S29-S30. [DOI]
Journal Contribution ResearchOnline@JCU
Trollope, Alexandra; Bellei, Maria; Woolley, Torres; Harris, Ryan (2017) Australian Conference on Science and Mathematics Education Evaluation of an interactive E-book as an effective resource for student engagement and learning in anatomy Monash University, VIC, Australia, .
Conference Contribution Open Access ResearchOnline@JCU
Croese, Alexander; Zubair, Omar; Lonie, James; Trollope, Alex; Vangaveti, Venkat; Ho, Yik-Hong (2017) Spot Light on the Rectum A meta-analysis of the prevalence of low anterior resection syndrome and systemic review of risk factors Paris, France, .
Conference Contribution Open Access ResearchOnline@JCU