Patrick Schaeffer

Research Overview

The study of macromolecular interactions

The group combines expertise in the functional and structural characterization of protein complexes and is particularly interested in the study of protein–ligand interactions. Proteins of interest to the group include: a) bacterial DNA replication proteins, transcription factors and metabolic enzymes; and b) viral nucleoproteins, replication proteins and integrases.

Development of ultrasensitive immunodiagnostics

This program involves the development of innovative diagnostic platforms. The group’s successes include the development of the TT-lock Immuno-PCR platform and its application for the diagnosis of melioidosis as well as a sensitive assay to detect the presence of the influenza A nucleoprotein and seafood allergy IgE. Currently the group focuses on developing a new rapid test platform technology for Ebola, influenza A/B, SARS-CoV-2, MERS and RSV.

Drug discovery

This program is in full swing and builds on recent successes in the development of innovative high-throughput assays using the principle of high-throughput differential scanning fluorimetry of GFP-tagged proteins. The group is interested in the identification of drug leads and their mechanisms of action. Diseases of particular interest to the group include: multidrug-resistant ESKAPEE infection, melioidosis, tuberculosis, malaria and HIV.

Development of bio- and nanotechnologies

The group has a long-standing interest and track-record in developing innovative sensing technologies based on fluorescence, biomolecular recognition and protein thermal stability.

Expertise

Protein Biochemistry; DNA replication; Protein-ligand interactions; Immuno-PCR diagnostics; Surface Plasmon Resonance; Protein unfolding and aggregation; Drug targets; High-throughput biotechnologies; GFP