Inhibition of Replication Fork Formation and Progression: Targeting the Replication Initiation and Primosomal Proteins
Journal Publication ResearchOnline@JCUAbstract
Over 1.2 million deaths are attributed to multi-drug-resistant (MDR) bacteria each year. Persistence of MDR bacteria is primarily due to the molecular mechanisms that permit fast replication and rapid evolution. As many pathogens continue to build resistance genes, current antibiotic treatments are being rendered useless and the pool of reliable treatments for many MDR-associated diseases is thus shrinking at an alarming rate. In the development of novel antibiotics, DNA replication is still a largely underexplored target. This review summarises critical literature and synthesises our current understanding of DNA replication initiation in bacteria with a particular focus on the utility and applicability of essential initiation proteins as emerging drug targets. A critical evaluation of the specific methods available to examine and screen the most promising replication initiation proteins is provided.
Journal
International Journal of Molecular Sciences
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Volume
24
ISBN/ISSN
1422-0067
Edition
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Issue
10
Pages Count
21
Location
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Publisher
MDPI
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Publisher Location
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Publish Date
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Url
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Date
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EISSN
N/A
DOI
10.3390/ijms24108802