Medicine
Erin Waters
- JCU Associate Professor
- erin.waters@jcu.edu.au
Shiv Thanigaimani
- Senior Research Fellow, Peripheral Vascular Disease (PVD)
- shiv.thanigaimani@jcu.edu.au
Alkira Deren
- Clinical Research Officer
- alkira.venn@jcu.edu.au
Michael Robinson
- JCU Lecturer
- michael.robinson@jcu.edu.au
Nalita Turner
- Research Officer
- nalita.turner@jcu.edu.au
Bunmi Malau-Aduli
- JCU Professor
- bunmi.malauaduli@jcu.edu.au
Jenna Graffini
- Research Project Manager
- jenna.graffini@jcu.edu.au
Mel Muscat
- Adjunct Research Fellow
- melody.muscat@jcu.edu.au
Yvonne Hornby-Turner
- Adjunct Research Fellow
- yvonne.hornbyturner@jcu.edu.au
Geoffrey Dobson
- Professor
- geoffrey.dobson@jcu.edu.au
Optimisation of Ultra-Small Volume Adenosine, Lidocaine and Mg2+ (ALM) Fluid Resuscitation and 72hr Stabilisation Drip for Uncontrolled Haemorrhage and TBI (Old ID 23011)
Hayley Letson
26 Sep 2016 - 25 Dec 2020
The resuscitation and stabilisation properties of ALM 'one-two treatment' will be investigated in rats after uncontrolled blood loss ± traumatic brain injury, and a translational arm in pigs followed for 72hrs to mimic prolonged far-forward retrieval delays. The aim is to show improved survival is associated with improved cardiac function, reduced inflammation, less coagulopathy and less secondary 'it' complications. The ALM therapy has the potential to reduce morbidity and mortality on the battlefield by buying time for treatment, stabilisation and preparedness of causalities for safer evacuation. The study also has broad-spectrum public purpose for pre-hospital trauma and aeromedical transport.
(COMFITE) Efficacy, acceptability and adherence with custom-made footwear in people with a history of diabetes-related foot disease. (Old ID 26968)
Joseph Moxon
01 Jan 2021 - 12 Dec 2022
Approximately 8% (n=80,000) of Northern Australians have diabetes of whom about a quarter (n=20,000) will develop foot disease putting them at risk of amputation and death and costing ~$24 million each year. The most common cause of diabetes-related foot complications is excessive pressure on an area of an insensate foot. Footwear designed to limit pressure on the feet has been shown to reduce the risk of foot ulcers. The most appropriate type of footwear is however unknown. This pilot clinical trial examines the efficacy and acceptability of footwear designed to the shape of an individuals’ feet using three-dimensional printing.
Proposed development of revised framework for operational and implementation research in health and disease control programmes. (Old ID 27222)
Michelle Redman-MacLaren
26 Apr 2021 - 24 Sep 2021
Strong, responsive and resilient health systems are the critical foundation for global health security. Health systems depend on effective functioning of both people and networks in order to implement effective disease control programmes, detect and respond quickly to infectious disease threats and develop evidence-informed policy/practice. The purpose of this work is to develop a revised framework for operational and implementation research (OR/IR) in health and disease control programs. This framework can be used to develop adequate and sustainable OR/IR capacity in public health programs and create an organisational culture of policy and practice that is informed by evidence-informed decision making.
Proposed development of revised framework for operational and implementation research in health and disease control programmes. (Old ID 27222)
Karen Johnston
26 Apr 2021 - 24 Sep 2021
Strong, responsive and resilient health systems are the critical foundation for global health security. Health systems depend on effective functioning of both people and networks in order to implement effective disease control programmes, detect and respond quickly to infectious disease threats and develop evidence-informed policy/practice. The purpose of this work is to develop a revised framework for operational and implementation research (OR/IR) in health and disease control programs. This framework can be used to develop adequate and sustainable OR/IR capacity in public health programs and create an organisational culture of policy and practice that is informed by evidence-informed decision making.
Assessment of the efficacy of a novel treatment for Peripheral Artery Disease (PAD) (Old ID 26206)
Joseph Moxon
01 Jul 2018 - 31 Dec 2020
Blockage of leg arteries (peripheral artery disease - PAD) leads to severe exertional leg pain (intermittent claudication), impaired walking ability, reduced health-related quality of life, and high risk of amputation and death. Multiple lines of evidence suggest that metformin, a cheap and safe medication, promotes formation of new vessels, improves microcirculation and muscle function,s and limits pain.
Design, implementation, and evaluation of an intervention for a kidney transplant service in northern Queensland (Phase 2)
Andrew Mallett
11 Dec 2025 - 31 Oct 2029
This study will explore the experiences of kidney transplant recipients and health professionals, perceived barriers to transplantation and ways in which patient experiences could be improved. This data will inform the design of an intervention for the proposed new kidney transplant service for northern Queensland, which will be implemented and evaluated using a prospective cohort study. The expected outcome of this study is that the intervention will influence the development and provision of clinical services for the northern Queensland kidney transplant service, improving patient experiences and clinical outcomes.
Metformin in the management of abdominal aortic aneurysm (MAGIC) (Old ID 25135)
Joseph Moxon
01 Jan 2019 - 31 Dec 2020
MAGIC will be the first trial to assess the value of metformin wiuth significant preliminary data to suggest it can slow AAA growth. This trial offers the possibility of identifying a new treatment modality for an increasingly common condition, which would markedly change clinical practice.
Tele-DFD: Remotely providing effective healthcare for diabetic foot disease (Old ID 27644)
Joseph Moxon
01 Jul 2022 - 30 Sep 2026
Current models of care for diabetes-associated foot disease (DFD) management are not sustainable due to the recurring nature of this condition and lead to enormous social and economic burden (~$24 million / year). Models of healthcare that are financially viable and effective at meeting the challenges of the dispersed population of Northern Australia are urgently needed to reduce the rates of DFD-related amputations, and costs associated with preventable hospital admissions and ongoing treatment. This project will test whether a telehealth model of care (Tele-DFD) is more effective at achieving secondary prevention than the current usual face to face consultation model. If effective this model offers the potential of improved health outcomes and substantially reducing geographic disparity and social and economic burden from DFD.
Women's Action for Mums and Bubs (WOMB): A pragmatic trial of participatory women's groups to improve Indigenous maternal and child health (Old ID 23276)
Karen Carlisle
01 Jan 2018 - 31 Dec 2023
There is strong evidence elsewhere that involving community women in decision-making about strategies to improve the health of mothers and babies is a cheap and effective way of improving health. The WOMB study tests whether community women's groups improve the quality of maternal and child health care and outcomes in Aboriginal and Torres Strait Islander communities, the cost-effectiveness and mechanism of action.
Testing a novel treatment for diabetes-associated ischemic foot ulceration. (Old ID 24978)
Joseph Moxon
01 Jan 2020 - 31 Dec 2020
5000 Australians with diabetes have a leg amputations each year. This project investigates a novel drug therapy approach to reducing the need for leg amputations within an established rodent model. The aim of the study is to assess if administration of a direct activator of adenosine-5'-monophosphate (AMP)-activated protein kinase (AMPK) will promote healing within a rat model of diabetes and limb ischaemia-associated foot ulceration.
Update on the pathophysiology and medical treatment of peripheral artery disease
- 2022
- Nature Publishing Group
- Researchers:Jonathan Golledge
Potential benefits of phytochemicals for abdominal aortic aneurysm
- 2021
- Bentham Science
- Researchers:Jonathan Golledge
Clinical versus research genomics in kidney disease
- 2021
- Nature Publishing Group
- Researchers:Andrew Mallett
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01 Jan 2012
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01 Jan 2009
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01 Jan 2007
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01 Jan 1996
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