Projects 0
Publications 22
Awards 15

Biography

Background

Lisa Chilton is biomedical scientist specialising in physiology. She is the Section Head of Physiology within the Discipline of Biomedical Sciences and Molecular Biology (BSMB), providing oversight for the physiology teaching across multiple programs and fostering excellence in her fellow physiologists. Lisa is also the Chair of the BSMB Engagement and Marketing Committee, which she has overseen since 2016. This committee has delivered many engagement and marketing events for staff, undergraduate students, high school students and the public. Lisa teaches approximately 750 students each year across three colleges and from first to third year. She is the BSMB Honours Course Coordinator. Lisa was granted a research sabbatical at the University of Glasgow in Scotland with Professor Godfrey Smith.

Research Interests

Lisa has been studying the cardiovascular system throughout her research career. She studied how the intestinal circulation was impaired with cirrhosis of the liver, the role of ATP-sensitive potassium channels in cardiac stunning, the role of membrane potential in activation of white blood cells, the role of potassium channels in controlling blood vessel diameter, and the electrophysiology of cardiac fibroblasts. Her most recent biomedicine research program concerns the intriguing question of how cardiac fibroblasts, adipocytes and myocytes interact within the heart in health and disease.

Lisa completed a Bachelor of Zoology, Master of Comparative Physiology and PhD (Physiology and Pharmacology) as well as a Postdoctoral program from the University of Calgary in Canada and did a postdoctoral fellowship at the University of Glasgow. She was also a visiting scientist in Pfizer's sexual health division in Sandwich, Kent, England, and in Professor Fran Ashcroft's lab in Oxford, England before joining James Cook University.

Lisa has maintained her collaborations with colleagues in Canada and the UK. She is involved in research projects studying epicardial adipose tissue, diabetes, obesity, cardiovascular diseases including rheumatic heart disease and heart failure, & ischaemic preconditioning at James Cook University. In collaboration with Cardiothoracic Surgeons at Townsville University Hospital and the University of Newcastle as well as biomedical scientists at James Cook University and the University of Newcastle, Lisa has established an exciting collaboration to use biological samples and clinical data donated by open-heart surgery patients to better understand the pathogenesis of skeletal muscle and cardiovascular disease in diabetic and obese patients. In collaboration with Dr Craig McFarlane and Associate Professor Lionel Hebbard, Lisa received a $50,000 SERTA grant (https://portfolio.jcu.edu.au/Projects/JCU1109).

In addition to her physiology research interests, Lisa collaborates with Emeritus Professor Glen Chilton (ornithologist and behavioural ecologist) from St. Mary's University in Canada, studying the roosting behaviour of Pied Wagtails in the UK and of Sulphur-crested Cockatoos in Australia.

Publications in Preparation

Chilton G, Strickland J, Hayakijkosol O, Chilton L. In prep. Can Sulphur-crested Cockatoos (Cacatua sanguinea) make adaptive responses in their behaviour when a cyclone is imminent? To be submitted to Ibis

Chilton G, Baker R, Chilton L. In prep. Communal nocturnal roosting behavior of Sulphur-crested Cockatoos (Cacatua sanguinea) and Little Correlas (Cacatua galerita). To be submitted to Ibis.

Chilton G, Chilton L. In prep. Communal nocturnal roosting behavior of Pied Wagtails, Motacilla alba yarrelli, in the UK may be an epiphenomenon. To be submitted to the Journal of Urban Ecology.

Research

Research Interests

The role of scar-forming fibroblasts and myofibroblasts in electrical connectivity in the heart following heart attack

Cardiac electrophysiology

Functional studies of manipulating the membrane potential and K+ channel function in cardiac fibroblasts and myofibroblasts

Characteristics and control of contractility in cardiac myofibroblasts

Effect of ischaemia/reperfusion injury and ischaemic preconditioning on fibroblast to myofibroblast differentiation

The cardiovascular system

Role of epicardial adipose tissue in health and disease, with particular interest in diabetic patients with or without obesity

Traditional communal nocturnal roosting in birds - why should birds do so?

Do Sulphur-crested Cockatoos make adaptive responses to approaching cyclones?

Teaching

Teaching Interests

Lisa teaches physiology from introductory to advanced levels. Her expertise includes cardiac physiology and pathophysiology, focusing on electrophysiology; smooth and skeletal muscle physiology and renal physiology.


Research Advisor Accreditation

Advisor Type

Secondary


Taught Modules

Completed Honours and External Research Students

Can intraoperative imaging of epicardial adipose tissue be useful in estimating intramyocardial fibrosis in patients undergoing open heart surgery?
HONOURS
Investigation of diabetic control in the cohort of non-emergency open heart surgery patients in Townsville University Hospital
COURSEWORK_MASTERS

Available Projects

Activities

Awards

Education

Employment

Media

Associations

Output

Krishnan, Anirudh; Sharma, Harman; Yuan, Daniel; Trollope, Alex; Chilton, Lisa (2022) 'The Role of Epicardial Adipose Tissue in the Development of Atrial Fibrillation, Coronary Artery Disease and Chronic Heart Failure in the Context of Obesity and Type 2 Diabetes Mellitus: A Narrative Review'. Journal of Cardiovascular Development and Disease, 9 . [DOI]
Journal Publication Open Access ResearchOnline@JCU
Krishnan, Anirudh; Chilton, Emily; Raman, Jaishankar; Saxena, Pankaj; McFarlane, Craig; Trollope, Alexandra F.; Kinobe, Robert; Chilton, Lisa (2021) 'Are interactions between epicardial adipose tissue, cardiac fibroblasts and cardiac myocytes instrumental in atrial fibrosis and atrial fibrillation?'. Cells, 10 (9). [DOI]
Journal Publication Open Access ResearchOnline@JCU
McArthur, Lisa; Riddell, Alexandra; Chilton, Lisa; Smith, Godfrey L.; Nicklin, Stuart A. (2020) 'Regulation of connexin 43 by interleukin 1 beta in adult rat cardiac fibroblasts and effects in an adult rat cardiac myocyte: fibroblast co-culture model'. Heliyon, 6 (1). [DOI]
Journal Publication Open Access ResearchOnline@JCU
Hem, Nur-Aish; Phie, James; Chilton, Lisa; Kinobe, Robert (2019) 'A volume-pressure tail cuff method for hemodynamic parameters: comparison of restraint and light isoflurane anesthesia in normotensive male Lewis rats'. Journal of Pharmacological and Toxicological Methods, 100 . [DOI]
Journal Publication ResearchOnline@JCU
Pertiwi, Kartika R.; Hillman, Rachael M.; Scott, Coralie A.; Chilton, Lisa (2019) 'Ischemia Reperfusion Injury Produces, and Ischemic Preconditioning Prevents, Rat Cardiac Fibroblast Differentiation: Role of KATP Channels'. Journal of Cardiovascular Development and Disease, 6 (2). [DOI]
Journal Publication Open Access ResearchOnline@JCU
Gorton, Davina; Sikder, Suchandan; Williams, Natasha L.; Chilton, Lisa; Rush, Catherine M.; Govan, Brenda L.; Cunningham, Madeleine W.; Ketheesan, Natkunam (2016) 'Repeat exposure to group A streptococcal M protein exacerbates cardiac damage in a rat model of rheumatic heart disease'. Autoimmunity, 49 (8):563-570. [DOI]
Journal Publication ResearchOnline@JCU
Phie, James; Haleagrahara, Nagaraja; Newton, Patricia; Constantinoiu, Constantin; Sarnyai, Zoltan; Chilton, Lisa; Kinobe, Robert (2015) 'Prolonged subcutaneous administration of oxytocin accelerates angiotensin II-induced hypertension and renal damage in male rats'. PLoS ONE, 10 (9):1-19. [DOI]
Journal Publication Open Access ResearchOnline@JCU
McArthur, Lisa; Chilton, Lisa; Smith, Godfrey L.; Nicklin, Stuart A. (2015) 'Electrical consequences of cardiac myocyte: fibroblast coupling'. Biochemical Society Transactions, 43 :513-518. [DOI]
Journal Publication ResearchOnline@JCU
Chilton, Lisa; Smirnov, Sergey V.; Loutzenhiser , Kathy; Wang, Xuemei; Loutzenhiser, Rodger (2011) 'Segment-specific differences in the inward rectifier K+ current along the renal interlobular artery'. Cardiovascular Research, 92 (1):169-177. [DOI]
Journal Publication ResearchOnline@JCU
Freed, Darren H.; Chilton, Lisa; Li, Yun; Dangerfield, Aran L.; Raizman, Joshua E.; Rattan, Sunil G.; Visen, Neeraj; Hryshko, Larry V.; Dixon, Ian M.C. (2011) 'Role of myosin light chain kinase in cardiotrophin-1-induced cardiac myofibroblast cell migration'. American Journal of Physiology-Heart and Circulatory Physiology, 301 :H514-H522. [DOI]
Journal Publication ResearchOnline@JCU
Figura, M.; Chilton, L.; Liacini, A.; Viskovic, M.Maric; Phan, V.; Knight, D.; Millar, T.M.; Patel, K.; Kubes , P.; Giles, W.R.; Tibbles, L.A. (2009) 'Blockade of KATP channels reduces endothelial hyperpolarization and leukocyte recruitment upon reperfusion after hypoxia'. American Journal of Transplantation, 9 (4):687-696. [DOI]
Journal Publication ResearchOnline@JCU
Chilton, Lisa; Loutzenhiser, Kathy; Morales, Ezequiel; Breaks, Jennifer; Kargacin, Gary J.; Loutzenhiser, Rodger (2008) 'Inward rectifier K+ currents and Kir2.1 expression in renal afferent and efferent arterioles'. Journal of the American Society of Nephrology, 19 (1):69-76. [DOI]
Journal Publication ResearchOnline@JCU
MacCannell, K. Andrew; Bazzazi, Hojjat; Chilton, Lisa; Shibukawa, Yoshiyuki; Clark, Robert B.; Giles, Wayne R. (2007) 'A mathematical model of electrotonic interactions between ventricular myocytes and fibroblasts'. Biophysical Journal, 92 (11):4121-4132. [DOI]
Journal Publication ResearchOnline@JCU
Chilton, Lisa; Giles, Wayne R.; Smith, Godfrey L. (2007) 'Evidence of intercellular coupling between co-cultured adult rabbit ventricular myocytes and myofibroblasts'. Journal of Physiology, 583 (1):225-236. [DOI]
Journal Publication ResearchOnline@JCU
Shibukawa, Yoshiyuki; Chilton, E. Lisa; MacCannell, K. Andrew; Clark, Robert B.; Giles, Wayne R. (2005) 'K+ currents activated by depolarization in cardiac fibroblasts'. Biophysical Journal, 88 (6):3924-3935. [DOI]
Journal Publication ResearchOnline@JCU
Chilton, L.; Ohya, S.; Freed, D.; George, E.; Drobic, V.; Shibukawa, Y.; MacCannell, K.A.; Imaizumi, Y.; Clark, R.B.; Dixon, I.M.C.; Giles, W.R. (2005) 'K+ currents regulate the resting membrane potential, proliferation, and contractile responses in ventricular fibroblasts and myofibroblasts'. American Journal of Physiology-Heart and Circulatory Physiology, 288 :H2931-H2939. [DOI]
Journal Publication ResearchOnline@JCU
Kinobe, Robert; Hem, Nur-Aisha; Rudd, Donna; Kapoor, Ranjna; Chilton, Lisa (2021) 'Maintaining normal blood pressure in a renovascular stenosis model of hypertension in adult Lewis rats: putative physiological modulation of the renin-angiotensin system' FASEB Journal, 35 (S1) :01655-01655.
Journal Contribution ResearchOnline@JCU
Kinobe, Robert T.; Phie, James; Haleagrahara, Nagaraja; Chilton, Lisa (2016) 'Carbon monoxide releasing molecule-3 alleviates angiotensin II-induced hypertrophy and apoptosis by inhibiting oxidative and endoplasmic reticulum stress in H9c2 cardiomyocytes' FASEB Journal, 30 (1) . [DOI]
Journal Contribution ResearchOnline@JCU
Munns, Suzanne; Chilton, Lisa (2014) International Journal of Innovation in Science and Mathematics Education Demand evidence and think critically: building research excellence in tomorrow's scientists Sydney, NSW, Australia,
Conference Publication Open Access ResearchOnline@JCU
Pertiwi, K.; Chilton, E. (2011) Proceedings of The Physiological Society Ischaemic preconditioning prevents the differentiation induced by ischaemia/reperfusion injury of rat cardiac fibroblasts into myofibroblasts Oxford, UK, .
Conference Contribution ResearchOnline@JCU
Gorton, D.; Chilton, L.; Day, J.; Govan, B.; Bryant, S.; Tacke, S.; Ketheesan, N. (2010) 2010 Fulbright 60th Anniversary Symposium A novel model to assess disease severity and prevention strategies in rheumatic heart disease Cairns, Australia, .
Conference Contribution Open Access ResearchOnline@JCU
MacCannell, K.A.; Chilton, L.; Smith, G.L.; Giles, W.R. (2015) 'Mathematical simulations of sphingosine-1-phosphate actions on mammalian ventricular myofibroblasts and myocytes' In: MacCannell, K.A., Chilton, L., Smith, G.L., and Giles, W.R. (2015) Mathematical simulations of sphingosine-1-phosphate actions on mammalian ventricular myofibroblasts and myocytes. In: Dixon, Ian M.C., and Wigle, Jeffrey T., (eds.) Cardiac Fibrosis and Heart Failure: cause or effect? Advances in Biochemistry in Health and Disease (13). Springer, Cham, Switzerland, pp. 299-322(Eds.). Cardiac Fibrosis and Heart Failure: cause or effect?. Cham, Switzerland : Springer. [DOI]