Projects 2
Publications 20
Awards 16

Contact Details

Postdoctoral Research Fellow

Biography

Dr. Harindra Sathkumara is a highly dedicated postdoctoral researcher currently affiliated with Australian Institute of Tropical Health and Medicine at James Cook University (JCU). With a strong background in immunology and infectious diseases, his current research endeavors revolve around understanding complex immune mechanisms underlying tuberculosis (TB); a highly infectious and potentially life-threatening disease caused by the bacteria Mycobacterium tuberculosis (Mtb). As an early career researcher, he has made significant contributions to the field of TB immunology. His research focuses on unraveling the immune correlates of BCG vaccination and protection against tuberculosis (TB) in humans as well as understanding the intricate mechanisms underlying tuberculosis susceptibility, vaccine efficacy and disease interactions in high-risk populations, particularly in individuals with HIV/AIDS and type 2 diabetes, contributing to a deeper understanding of tuberculosis immunology. Harindra's research findings have featured in prestigious scientific journals such as PNAS and Science Advances and has also been presented at numerous national and international conferences, further contributing to the scientific community's knowledge and understanding. Driven by a passion for advancing knowledge and improving human health, Harindra has received several notable awards, and scholarships throughout their academic journey. These include the JCU's Dean's Award for Research Higher Degree Excellence and the prestigious Early Career Scientist Award from the CTVD-Bill and Melinda Gates Foundation, highlighting the exceptional contributions to the field. With a commitment to excellence and a relentless pursuit of scientific breakthroughs, Harindra engages in collaborative efforts with fellow scientists, clinicians, and industry professionals.

Research

Research Interests

Tuberculosis

BCG

Trained Immunity

Novel anti-TB vaccines

TB immunology

Projects

Teaching

Research Advisor Accreditation

Advisor Type

Primary


Current JCU Research Students

Understanding Immunogenicity, Safety and Protective Efficacy of next-generation Vaccines for Tuberculosis
Doctor of Philosophy (Medical, Molecular and Veterinary Sciences)

Activities

Outreach

Education

Media

Associations

Awards

Employment

Languages

Output

Sathkumara, Harindra Darshana (2020) Mechanisms driving tuberculosis susceptibility and vaccine efficacy in HIV/AIDS and type 2 diabetes. [Thesis] [DOI]
Other Publication Open Access ResearchOnline@JCU
Zhao, Guangzu; Sathkumara, Harindra D.; Miranda-Hernandez, Socorro; Seifert, Julia; Valencia Hernandez, Ana Maria; Puri, Munish; Huang, Wenbin; Toth, Istvan; Daly, Norelle; Skwarczynski, Mariusz; Kupz, Andreas (2025) 'A Modular Self-Assembling and Self-Adjuvanting Multiepitope Peptide Nanoparticle Vaccine Platform to Improve the Efficacy and Immunogenicity of BCG'. Small, 21 (7). [DOI]
Journal Publication ResearchOnline@JCU
Miranda-Hernandez, Socorro; Sathkumara Mudiyanselage, Harindra; Zhao, Guangzu; Schofield, Louis; Kupz, Andreas (2025) 'Co-administration of a synthetic saccharide conjugate vaccine with BCG provides synergistic protection against murine tuberculosis'. Vaccine, 68 . [DOI]
Journal Publication Open Access ResearchOnline@JCU
Enjeti, Aditya; Sathkumara, Harindra Darshana; Kupz, Andreas (2023) 'Impact of the gut-lung axis on tuberculosis susceptibility and progression'. Frontiers in Microbiology, 14 :1-8. [DOI]
Journal Publication Open Access ResearchOnline@JCU
Heijmenberg, Isis; Husain, Aliabbas; Sathkumara Mudiyanse, Harindra D.; Muruganandah, Visai; Seifert, Julia; Miranda-Hernandez, Socorro; Kashyap, Rajpal Singh; Field, Matt A.; Krishnamoorthy, Gopinath; Kupz, Andreas (2021) 'ESX-5-targeted export of ESAT-6 in BCG combines enhanced immunogenicity & efficacy against murine tuberculosis with low virulence and reduced persistence'. Vaccine, 39 (50):7265-7276. [DOI]
Journal Publication ResearchOnline@JCU
Sathkumara, Harindra D.; Eaton, Janet L.; Field, Matt A.; Govan, Brenda L.; Ketheesan, Natkunam; Kupz, Andreas (2021) 'A murine model of tuberculosis/type 2 diabetes comorbidity for investigating the microbiome, metabolome and associated immune parameters'. Animal Models and Experimental Medicine, 4 (2):181-188. [DOI]
Journal Publication Open Access ResearchOnline@JCU
Sathkumara, Harindra D.; Muruganandah, Visai; Cooper, Martha M.; Field, Matt A.; Alim, Md Abdul; Brosch, Roland; Ketheesan, Natkunam; Govan, Brenda; Rush, Catherine M.; Henning, Lars; Kupz, Andreas (2020) 'Mucosal delivery of ESX-1–expressing BCG strains provides superior immunity against tuberculosis in murine type 2 diabetes'. National Academy of Sciences. Proceedings, 117 (34):20848-20859. [DOI]
Journal Publication ResearchOnline@JCU
Muruganandah, Visai; Sathkumara, Harindra D.; Pai, Saparna; Rush, Catherine M.; Brosch, Roland; Waardenberg, Ashley J.; Kupz, Andreas (2020) 'A systematic approach to simultaneously evaluate safety, immunogenicity, and efficacy of novel tuberculosis vaccination strategies'. Science Advances, 6 (10). [DOI]
Journal Publication Open Access ResearchOnline@JCU
Sathkumara, Harindra D.; Hansen, Karyina; Miranda-Hernandez, Socorro; Govan, Brenda; Rush, Catherine M.; Henning, Lars; Ketheesan, Natkunam; Kupz, Andreas (2020) 'Disparate effects of metformin on Mycobacterium tuberculosis infection in diabetic and nondiabetic mice'. Antimicrobial Agents and Chemotherapy, 65 (1). [DOI]
Journal Publication ResearchOnline@JCU
Alim, Md Abdul; Sikder, Suchandan; Sathkumara Mudiyanselage, Harindra; Kupz, Andreas; Rush, Catherine M.; Govan, Brenda L.; Ketheesan, Natkunam (2019) 'Dysregulation of key cytokines may contribute to increased susceptibility of diabetic mice to Mycobacterium bovis BCG infection'. Tuberculosis, 115 :113-120. [DOI]
Journal Publication ResearchOnline@JCU
Sathkumara, Harindra D.; Pai, Saparna; de Jesús Aceves-Sánchez, Michel; Ketheesan, Natkunam; Flores-Valdez, Mario Alberto; Kupz, Andreas (2019) 'BCG vaccination prevents reactivation of latent lymphatic murine tuberculosis independently of CD4+ T cells'. Frontiers in Immunology, 10 .
Journal Publication Open Access ResearchOnline@JCU
Sathkumara, Harindra D.; Merritt, Adam; Corea, Enoka; Krishnananthasivam, Shivankari; Natesan, Mohan; Inglis, Timothy J.J.; De Silva, Aruna (2018) 'Clinical, Bacteriologic, and Geographic Stratification of Melioidosis Emerges from the Sri Lankan National Surveillance Program'. American Journal of Tropical Medicine and Hygiene, 98 (2):607-615. [DOI]
Journal Publication ResearchOnline@JCU
Muruganandah, Visai; Sathkumara, Harindra D.; Navarro, Severine; Kupz, Andreas (2018) 'A systematic review: the role of resident memory T cells in infectious diseases and their relevance for vaccine development'. Frontiers in Immunology, 9 :1-21. [DOI]
Journal Publication Open Access ResearchOnline@JCU
Mohan, Natesan; Corea, Enoka; Krishnananthasivam, Shivankari; Sathkumara, Harindra Darshana; Dankmeyer, Jennifer; Dyas, Beverly K.; Amemiya, Kei; De Silva, Aruna; Ulrich, Robert G. (2017) 'Calprotectin as a Biomarker for Melioidosis Disease Progression and Management'. Journal of Clinical Microbiology, 55 :1205-1210. [DOI]
Journal Publication ResearchOnline@JCU
Krishnananthasivam, Shivankari; Sathkumara, Harindra Dharshan; Corea, Enoka; Natesan, Mohan; De Silva, Aruna Dharshan (2017) 'Gene Expression Profile of Human Cytokines in Response to Burkholderia pseudomallei Infection'. mSphere, 2 (2). [DOI]
Journal Publication Open Access ResearchOnline@JCU
Krishnananthasivam, Shivankari; Jayathilaka, Nimanthi; Sathkumara, Harindra Darshana; Corea, Enoka; Natesan, Mohan; De Silva, Aruna (2017) 'Host gene expression analysis in Sri Lankan melioidosis patients'. PLoS Neglected Tropical Diseases, 11 (6). [DOI]
Journal Publication Open Access ResearchOnline@JCU
Sathkumara Mudiyanselage, H.D.; De Silva, N.R.; Handunnetti, S.; De Silva, A.D. (2015) 'Genetics of common variable immunodeficiency: role of transmembrane activator and calcium modulator and cyclophilin ligand interactor'. International Journal of Immunogenetics, 42 (4):239-253. [DOI]
Journal Publication ResearchOnline@JCU
Jayasinghearachch, Himali S.; Francis, Vaithehi R.; Sathkumara, Harindra D.; Krishnananthasivam, Shivankari; Masakorala, Jayanthi; Muthugama, Thilini; De Silva, Aruna; Enoka, Corea (2021) 'Nonclonal Burkholderia pseudomallei Population in Melioidosis Case Cluster, Sri Lanka' Emerging Infectious Diseases, 27 (11) :2955-22957. [DOI]
Journal Contribution Open Access ResearchOnline@JCU
Jayasinghearachchi, Himali S.; Corea, Enoka M.; Krishnananthasivam, Shivankari; Sathkumara, Harindra D.; Francis, Vaithehi R.; Abeysekere, Thimirangi R.; De Silva, Aruna Dharshan (2019) 'Whole-genome sequences of eight clinical isolates of Burkholderia pseudomallei from melioidosis patients in Eastern Sri Lanka' Microbiology Resource Announcements, 8 (33) . [DOI]
Journal Contribution Open Access ResearchOnline@JCU
Sathkumara, Harindra D.; Valencia-Hernandez, Ana Maria; Kupz, Andreas (2025) 'Pre-clinical studies and animal models' In: Sathkumara, Harindra D., Valencia-Hernandez, Ana Maria, and Kupz, Andreas (2025) Pre-clinical studies and animal models. In: Bettencourt, Paulo J.G., (ed.) Tuberculosis Vaccines. Springer, pp. 153-202(Eds.). Tuberculosis Vaccines. : Springer. [DOI]