Paul Giacomin
- paul.giacomin@jcu.edu.au
https://orcid.org/0000-0002-6326-6792- Research Development and Partnership Advisor
- Research & Innovation Services
Projects
12
Publications
75
Awards
0
Biography
Dr. Paul Giacomin is currently a Senior Research Fellow in the Australian Institute of Tropical Health and Medicine at JCU Cairns. Since completing his PhD studies at the University of Adelaide in 2008, his research interests have focussed on understanding the molecular and cellular mechanisms by which immune responses to parasitic helminths (worms) are initiated and regulated. Dr. Giacomin underwent his postdoctoral training at the University of Pennsylvania between 2008 and 2012 in the laboratory of Dr. David Artis, where he was awarded fellowships from the American-Australian Association, as well as the NHMRC, to conduct his research. Dr. Giacomin continued his fellowship at JCU Cairns in 2012, where he continues to investigate the key immune cells and cytokines involved in immunity to intestinal worms, as well as exploring the potential beneficial effects that worm infection may have in alleviating inflammation associated with autoimmune diseases.
Research
Projects
Preclinical evaluation of novel drug lead compounds discovered from Wet Tropics plant (Old ID 28949)
01 Jan 2023 - 15 Sep 2025
Novel therapeutics for diabetes sourced from Northern Australian biota. (Old ID 27346)
02 Aug 2021 - 30 Jun 2023
Novel therapeutics for diabetes sourced from Northern Australian biota. (Old ID 27321)
01 Jul 2021 - 30 Jun 2022
Personal Protective Biosystems - Membranes and commensal helminths (MaCH) (Old ID 26776)
15 Apr 2021 - 14 Apr 2026
Laser based diagnostics for STH infections (Old ID 26822)
01 Jan 2020 - 30 Apr 2022
Hookworm peptide therapeutic for oral treatment of IBD (Old ID 26317)
01 Jan 2020 - 30 Jun 2022
Can experimental hookworm infection prevent metabolic disease/Type 2 diabetes? (Old ID 24710)
01 Jan 2018 - 01 Jun 2019
Hookworm therapy for restoring tolerance in coeliac disease (Old ID 22142)
01 Oct 2016 - 30 Mar 2018
New therapies for Coeliac Disease: Helminths and their secreted products. (Old ID 22524)
01 Feb 2016 - 01 May 2019
Teaching
Research Advisor Accreditation
Advisor Type
Primary
Taught Modules
[TM5503] Human ParasitologyLecturer
2025
[TM5503] Human ParasitologyLecturer
2024
[TM5503] Human ParasitologyLecturer
2021
[TM5503] Human ParasitologyLecturer
2026
Current JCU Research Students
Extracellular Vesicle Antigens as Hookworm Vaccine Candidates: Comparing Whole-Vesicle and Surface-Accessible (Corona) Protein Discovery Strategies
Doctor of Philosophy (Medical, Molecular and Veterinary Sciences)
Production of transgenic hookworms that secrete therapeutic foreign molecules
Doctor of Philosophy (Medical, Molecular and Veterinary Sciences)
Necator americanus recombinant proteins as novel therapeutics
Doctor of Philosophy (Medical and Molecular Sciences)
Completed JCU Research Students
Lung epithelial progenitor cell-mediated release of TGF- ß Regulates induction and persistence of ling CD*+ TRM cells following mucosal BCG vaccination
Doctor of Philosophy (Medical and Molecular Sciences)- 2024
Characterisation of Necator americanus excretory/secretory products
Doctor of Philosophy (Medical and Molecular Sciences)- 2020
Identifying the Antigenic Targets of Protective Immunity in Human Subjects Vaccinated with Irradiated Hookworm Larvae
Master of Philosophy (Medical, Molecular and Veterinary Sciences)- 2025
The anti-colitic properties of hookworm protein Na-AIP-1
Doctor of Philosophy (Medical and Molecular Sciences)- 2020
Experimental Hookworm Infection in Humans with Metabolic Disease
Doctor of Philosophy (Medical and Molecular Sciences)- 2022
Molecular profiling of immunity to infectious diseases using human challenge models
Doctor of Philosophy (Medical and Molecular Sciences)- 2020
Activities
Employment
Research Fellow, University of Pennsylvania
2009 - 2009
PhD candidate, University of Adelaide
2003 - 2008
BSc (Hons), University of Adelaide
2002 - 2002
BSc (Biomedical Science), University of Adelaide
1999 - 2002
Output
Blake, Judith A.; Seifert, Julia; Miranda-Hernandez, Socorro; Ruscher, Roland; Giacomin, Paul R.; Doolan, Denise L.; Kupz, Andreas (2025) 'Distal airway epithelial progenitors mediate TGF-β release to drive lung CD8+ TRM induction following mucosal BCG vaccination'. Mucosal Immunology, . [DOI]
Borup, Anne; Sharifpour, Mohammad Farouq; Rossen, Litten S.; Whitehead, Bradley; Boysen, Anders T.; Olesen, Rikke; Bohn, Anja B.; Ridolfi, Andrea; Brucale, Marco; Valle, Francesco; Paolini, Lucia; Radeghieri, Annalisa; Bergese, Paolo; Miles, Kim; Veitch, Margaret; Thomas, Tamara; Ruscher, Roland; Wangchuk, Phurpa; Giacomin, Paul; Loukas, Alex; Nejsum, Peter (2025) 'Helminth extracellular vesicles co-opt host monocytes to drive T cell anergy'. Journal of Extracellular Vesicles, 14 (1). [DOI]
Allen, Tammy; Castellanos Reynosa, Maria; Giacomin, Paul; Karunaweera, Nadira D.; Kupz, Andreas; Carlos LoL, Juan; Sharma, Dileep; Sikder, Suchandan; Tedla, Bemnet; van Eijk, Liza; Vojisavljevic, Danica; Zhao, Guangzu; Pai, Saparna (2024) 'Next-Generation Vaccines for Tropical Infectious Diseases'. International Journal of Infectious Diseases, 143 . [DOI]
Sikder, Suchandan; Pierce, Doris; Sarkar, Eti R.; McHugh, Connor; Quinlan, Kate G.R.; Giacomin, Paul; Loukas, Alex (2024) 'Regulation of host metabolic health by parasitic helminths'. Trends in Parasitology, 40 (5):386-400. [DOI]
Kariyawasam, Tharanga N.; Ciocchetta, Silvia; Visendi, Paul; Soares Magalhaes, Ricardo J.; Smith, Maxine E.; Giacomin, Paul R.; Sikulu-Lord, Maggy T. (2023) 'Near-infrared spectroscopy and machine learning algorithms for rapid and non-invasive detection of Trichuris'. PLoS Neglected Tropical Diseases, 17 (11). [DOI]
Effect of experimental hookworm infection on insulin resistance in people at risk of type 2 diabetes
2023
Pierce, Doris R.; Mcdonald, Malcolm; Merone, Leanne; Becker, Luke; Thompson, Fintan; Lewis, Chris; Ryan, Rachael Y.M.; Hii, Sze Fui; Zendejas-Heredia, Patsy; Traub, Rebecca J.; Field, Matthew A.; Rahman, Tony; Croese, John; Loukas, Alex; McDermott, Robyn; Giacomin, Paul R. (2023) 'Effect of experimental hookworm infection on insulin resistance in people at risk of type 2 diabetes'. Nature Communications, 14 . [DOI]
Cobos, Claudia; Bansal, Paramjit S.; Wilson, David T.; Jones, Linda; Zhao, Guangzu; Field, Matthew A.; Eichenberger, Ramon M.; Pickering, Darren A.; Ryan, Rachael Y.M.; Ratnatunga, Champa N.; Miles, John J.; Ruscher, Roland; Giacomin, Paul R.; Navarro, Severine; Loukas, Alex; Daly, Norelle L. (2022) 'Peptides derived from hookworm anti-inflammatory proteins suppress inducible colitis in mice and inflammatory cytokine production by human cells'. Frontiers in Medicine, 9 . [DOI]
Chapman, Paul R.; Llewellyn, Stacey; Jennings, Helen; Becker, Luke; Giacomin, Paul; McDougall, Rodney; Robson, Jennifer; Loukas, Alex; McCarthy, James (2022) 'The production of Necator americanus larvae for use in experimental human infection'. Parasites & Vectors, 15 . [DOI]
Langdon, Kane; Buitrago, Geraldine; Pickering, Darren; Giacomin, Paul; Loukas, Alex; Haleagrahara, Nagaraja (2022) 'Na-AIP-1 secreted by human hookworms suppresses collagen-induced arthritis'. Inflammopharmacology, 30 (2):527-535. [DOI]
Journal Publication
ResearchOnline@JCU
Ryan, Stephanie M.; Ruscher, Roland; Johnston, Wayne A.; Pickering, Darren A.; Kennedy, Malcolm W.; Smith, Brian O.; Jones, Linda; Buitrago, Geraldine; Field, Matt A.; Esterman, Adrian J.; McHugh, Connor P.; Browne, Daniel J.; Cooper, Martha M.; Ryan, Rachael Y.M.; Doolan, Denise L.; Engwerda, Christian R.; Miles, Kim; Mitreva, Makedonka; Croese, John; Rahman, Tony; Alexandrov, Kirill; Giacomin, Paul R.; Loukas, Alex (2022) 'Novel antiinflammatory biologics shaped by parasite–host coevolution'. Proceedings of the National Academy of Sciences of the United States of America, 119 (36). [DOI]
Shalash, Ahmed O.; Becker, Luke; Yang, Jieru; Giacomin, Paul; Pearson, Mark; Hussein, Waleed M.; Loukas, Alex; Toth, Istvan; Skwarczynski, Mariusz (2022) 'Development of a peptide vaccine against hookworm infection: Immunogenicity, efficacy, and immune correlates of protection'. Journal of Allergy and Clinical Immunology, 150 (1):157-169.e10. [DOI]
Journal Publication
ResearchOnline@JCU
Buitrago, Geraldine; Pickering, Darren; Ruscher, Roland; Cobos Caceres, Claudia; Jones, Linda; Cooper, Martha; Van Waardenberg, Ashley; Ryan, Stephanie; Miles, Kim; Field, Matthew; Dredge, Keith; Daly, Norelle L.; Giacomin, Paul R.; Loukas, Alex (2021) 'A netrin domain-containing protein secreted by the human hookworm Necator americanus protects against CD4 T cell transfer colitis'. Translational Research, 232 :88-102. [DOI]
Shalash, Ahmed O.; Becker, Luke; Yang, Jieru; Giacomin, Paul; Pearson, Mark; Hussein, Waleed M.; Loukas, Alex; Skwarczynski, Mariusz; Toth, Istvan (2021) 'Oral peptide vaccine against hookworm infection: correlation of antibody titers with protective efficacy'. Vaccines, 9 . [DOI]
Chapman, Paul R.; Giacomin, Paul; Loukas, Alex; McCarthy, James S. (2021) 'Experimental human hookworm infection: a narrative historical review'. PLoS Neglected Tropical Diseases, 15 (12). [DOI]
Chapman, Paul R.; Webster, Rebecca; Giacomin, Paul; Llewellyn, Stacey; Becker, Luke; Pearson, Mark; De Labastida Rivera, Fabian; O’Rourke, Peter; Engwerda, Christian R.; Loukas, Alex; McCarthy, James S. (2021) 'Vaccination of human participants with attenuated Necator americanus hookworm larvae and human challenge in Australia: a dose-finding study and randomised, placebo-controlled, phase 1 trial'. Lancet Infectious Diseases, 21 (12):1725-1736. [DOI]
Journal Publication
ResearchOnline@JCU
Douglas, Bonnie; Oyesola, Oyebola; Cooper, Martha M.; Posey, Avery; Tait Wojno, Elia; Giacomin, Paul R.; Herbert, De'Broski (2021) 'Immune system investigation using parasitic helminths'. Annual Review of Immunology, 39 :639-665. [DOI]
Journal Publication
ResearchOnline@JCU
Khudhair, Zainab; Alhallaf, Rafid; Eichenberger, Ramon M.; Whan, Jen; Kupz, Andreas; Field, Matt; Krause, Lutz; Wilson, David T.; Daly, Norelle L.; Giacomin, Paul; Sotillo, Javier; Loukas, Alex (2021) 'Gastrointestinal helminth infection improves insulin sensitivity, decreases systemic inflammation, and alters the composition of gut microbiota in distinct mouse models of Type 2 diabetes'. Frontiers in Endocrinology, 11 . [DOI]
Kupz, Andreas; Pai, Saparna; Giacomin, Paul R.; Whan, Jennifer A.; Walker, Robert A.; Hammoudi, Pierre-Mehdi; Smith, Nicholas C.; Miller, Catherine M. (2020) 'Treatment of mice with S4B6 IL‑2 complex prevents lethal toxoplasmosis via IL‑12‑ and IL‑18‑dependent interferon‑gamma production by non‑CD4 immune cells'. Scientific Reports, 10 . [DOI]
Ryan, Stephanie M.; Eichenberger, Ramon M.; Ruscher, Roland; Giacomin, Paul R.; Loukas, Alex (2020) 'Harnessing helminth-driven immunoregulation in the search for novel therapeutic modalities'. PLoS Pathogens, 16 (5). [DOI]
Croese, John; Miller, Gregory C.; Marquart, Louise; Llewellyn, Stacey; Gupta, Rohit; Becker, Luke; Clouston, Andrew D.; Welch, Christine; Sidorenko, Julia; Wallace, Leanne; Visscher, Peter M.; Remedios, Matthew L.; McCarthy, James S.; O'Rourke, Peter; Radford-Smith, Graham; Loukas, Alex; Norrie, Mark; Masson, John W.; Gearry, Richard B.; Rahman, Tony; Giacomin, Paul (2020) 'Randomized, placebo controlled trial of experimental hookworm infection for improving gluten tolerance in Celiac disease'. Clinical and Translational Gastroenterology, 11 . [DOI]
Bouchery, Tiffany; Moyat, Mati; Sotillo, Javier; Silverstein, Solomon; Volpe, Beatrice; Coakley, Gillian; Tsourouktsoglou, Theodora-Dorita; Becker, Luke; Shah, Kathleen; Kulagin, Manuel; Guiet, Romain; Camberis, Mali; Schmidt, Alfonso; Seitz, Arne; Giacomin, Paul; Le Gros, Graham; Papayannopoulos, Venizelos; Loukas, Alex; Harris, Nicola L. (2020) 'Hookworms evade host immunity by secreting a deoxyribonuclease to degrade neutrophil extracellular traps'. Cell Host & Microbe, 27 (2):277-289.e6. [DOI]
Journal Publication
ResearchOnline@JCU
Wangchuk, Phurpa; Shepherd, Catherine; Constantinoiu, Constantin; Ryan, Rachael Y.M.; Kouremenos, Konstantinos A.; Becker, Luke; Jones, Linda; Buitrago, Geraldine; Giacomin, Paul; Wilson, David; Daly, Norelle; Mcconville, Malcolm J.; Miles, John J.; Loukas, Alex (2019) 'Hookworm-derived metabolites suppress pathology in a mouse model of colitis and inhibit secretion of key inflammatory cytokines in primary human leukocytes'. Infection and Immunity, 87 (4). [DOI]
Journal Publication
ResearchOnline@JCU
Chenery, Alistair L.; Alhallaf, Rafid; Agha, Zainab; Ajendra, Jesuthas; Parkinson, James E.; Cooper, Martha M.; Chan, Brian H. K.; Eichenberger, Ramon M.; Dent, Lindsay A.; Robertson, Avril A. B.; Kupz, Andreas; Brough, David; Loukas, Alex; Sutherland, Tara E.; Allen, Judith E.; Giacomin, Paul R. (2019) 'Inflammasome-independent role for NLRP3 in controlling innate antihelminth immunity and tissue repair in the lung'. Journal of Immunology, 203 (10):2724-2734. [DOI]
Dastpeyman, Mohadeseh; Giacomin, Paul; Wilson, David; Nolan, Matthew J.; Bansal, Paramjit S.; Daly, Norelle L. (2019) 'A C-terminal fragment of chlorotoxin retains bioactivity and inhibits cell migration'. Frontiers in Pharmacology, 10 . [DOI]
Filbey, Kara J.; Camberis, Mali; Chandler, Jodie; Turner, Rufus; Kettle, Anthony J.; Eichenberger, Ramon M.; Giacomin, Paul; Le Gros, Graham (2019) 'Intestinal helminth infection promotes IL-5- and CD4+ T cell-dependent immunity in the lung against migrating parasites'. Mucosal Immunology, 11 :352-362. [DOI]
Eichenberger, Ramon M.; Ryan, Stephanie; Jones, Linda; Buitrago, Geraldine; Polster, Ramona; Montes de Oca, Marcela; Zuvelek, Jennifer; Giacomin, Paul R.; Dent, Lindsay A.; Engwerda, Christian R.; Field, Matthew A.; Sotillo, Javier; Loukas, Alex (2018) 'Hookworm secreted extracellular vesicles interact with host cells and prevent inducible colitis in mice'. Frontiers in Immunology, 9 . [DOI]
Chronic helminth infection perturbs the gut-brain axis, promotes neuropathology, and alters behavior
2018
Giacomin, Paul R.; Kraeuter, Ann Katrin; Albornoz, Eduardo A.; Jin, Shuting; Bengsston, Mia; Gordon, Richard; Woodruff, Trent M.; Urich, Tim; Sarnyai, Zoltán; Soares Magalhães, Ricardo J. (2018) 'Chronic helminth infection perturbs the gut-brain axis, promotes neuropathology, and alters behavior'. Journal of Infectious Diseases, 218 (9):1511-1516. [DOI]
Journal Publication
ResearchOnline@JCU
Alhallaf, Rafid; Agha, Zainab; Miller, Catherine M.; Robertson, Avril A.B.; Sotillo-Gallego, Javier; Croese, John; Cooper, Matthew A.; Masters, Seth L.; Kupz, Andreas; Smith, Nicholas C.; Loukas, Alex; Giacomin, Paul R. (2018) 'The NLRP3 inflammasome suppresses protective immunity to gastrointestinal helminth infection'. Cell Reports, 23 (4):1085-1098. [DOI]
Logan, Jayden; Navarro, Severine; Loukas, Alex; Giacomin, Paul (2018) 'Helminth-induced regulatory T cells and suppression of allergic responses'. Current Opinion in Immunology, 54 :1-6. [DOI]
Journal Publication
ResearchOnline@JCU
Eichenberger, Ramon M.; Hasanuzzaman, Talukder; Field, Matt A.; Wangchuk, Phurpa; Giacomin, Paul; Loukas, Alex; Sotillo, Javier (2018) 'Characterization of Trichuris muris secreted proteins and extracellular vesicles provides new insights into host–parasite communication'. Journal of Extracellular Vesicles, 7 (1). [DOI]
Shepherd, Catherine; Giacomin, Paul; Navarro, Severine; Miller, Catherine M.; Loukas, Alex; Wangchuk, Phurpa (2018) 'A medicinal plant compound, capnoidine, prevents the onset of inflammation in a mouse model of colitis'. Journal of Ethnopharmacology, 211 :17-28. [DOI]
Journal Publication
ResearchOnline@JCU
Sundaraneedi, Madhu; Eichenberger, Ramon M.; Al-Hallaf, Rafid; Yang, Dai; Sotillo, Javier; Rajan, Siji; Wangchuk, Phurpa; Giacomin, Paul R.; Keene, F. Richard; Loukas, Alex; Collins, J. Grant; Pearson, Mark S. (2018) 'Polypyridylruthenium(II) complexes exert in vitro and in vivo nematocidal activity and show significant inhibition of parasite acetylcholinesterases'. International Journal for Parasitology: Drugs and Drugs Resistance, 8 (1):1-7. [DOI]
Bouchery, Tiffany; Filbey, Kara; Shepherd, Amy; Chandler, Jodie; Patel, Deepa; Schmidt, Alfonso; Camberis, Mali; Peignier, Adeline; Smith, Adam A.T.; Johnston, Karen; Painter, Gavin; Pearson, Mark; Giacomin, Paul; Loukas, Alex; Bottazzi, Maria-Elena; Hotez, Peter; LeGros, Graham (2018) 'A novel blood-feeding detoxification pathway in Nippostrongylus brasiliensis L3 reveals a potential checkpoint for arresting hookworm development'. PLoS Pathogens, 14 (3). [DOI]
Hays, Russell; Giacomin, Paul; Olma, Lennart; Esterman, Adrian; McDermott, Robyn (2017) 'The relationship between treatment for Strongyloides stercoralis infection and type 2 diabetes mellitus in an Australian Aboriginal population: a three-year cohort study'. Diabetes Research and Clinical Practice, 134 :8-16. [DOI]
Journal Publication
ResearchOnline@JCU
Sakhaei Manesh, Vahid; Giacomin, Paul; Stoll, Richard (2017) 'Quantitative evaluation of root canal surface roughness after filing with adaptive reciprocating and continuous rotary instruments'. Microscopy Research and Technique, 80 (6):657-661. [DOI]
Journal Publication
ResearchOnline@JCU
Smallwood, Taylor B.; Giacomin, Paul R.; Loukas, Alex; Mulvenna, Jason P.; Clark, Richard J.; Miles, John J. (2017) 'Helminth immunomodulation in autoimmune disease'. Frontiers in Immunology, 8 . [DOI]
Cobos Caceres, Claudia; Bansal, Paramjit S.; Navarro, Severine; Wilson, David; Don, Laurianne; Giacomin, Paul; Loukas, Alex; Daly, Norelle L. (2017) 'An engineered cyclic peptide alleviates symptoms of inflammation in a murine model of inflammatory bowel disease'. Journal of Biological Chemistry, 292 (24):10288-10294. [DOI]
Journal Publication
ResearchOnline@JCU
Hookworm recombinant protein promotes regulatory T cell responses that suppress experimental asthma
2016
Navarro, Severine; Pickering, Darren A.; Ferreira, Ivana B.; Jones, Linda; Ryan, Stephanie; Troy, Sally; Leech, Andrew ; Hotez, Peter J.; Zhan, Bin; Laha, Thewarach; Prentice, Roger; Sparwasser, Tim; Croese, John; Engwerda, Christian R.; Upham, John W.; Julia, Valerie; Giacomin, Paul R.; Loukas, Alex (2016) 'Hookworm recombinant protein promotes regulatory T cell responses that suppress experimental asthma'. Science Translational Medicine, 8 (362). [DOI]
Journal Publication
ResearchOnline@JCU
Giacomin, Paul; Zakrzewski, Martha; Jenkins, Timothy P.; Su, Xiaopei; Al-Hallaf, Rafid; Croese, John; De Vries, Stefan; Grant, Andrew; Mitreva, Makedonka; Krause, Lutz; Loukas, Alex; Cantacessi, Cinzia (2016) 'Changes in duodenal tissue-associated microbiota following hookworm infection and consecutive gluten challenges in humans with coeliac disease'. Scientific Reports, 6 :1-10. [DOI]
Wangchuk, Phurpa; Giacomin, Paul R.; Pearson, Mark S.; Smout, Michael J.; Loukas, Alex (2016) 'Identification of lead chemotherapeutic agents from medicinal plants against blood flukes and whipworms'. Scientific Reports, 6 :1-10. [DOI]
Wangchuk, Phurpa; Pearson, Mark S.; Giacomin, Paul R.; Becker, Luke; Sotillo, Javier; Pickering, Darren; Smout, Michael J.; Loukas, Alex (2016) 'Compounds derived from the Bhutanese daisy, Ajania nubigena, demonstrate dual anthelmintic activity against Schistosoma mansoni and Trichuris muris'. PLOS Neglected Tropical Diseases, 10 (8):1-18. [DOI]
Hays, Russell; Esterman, Adrian; Giacomin, Paul; Loukas, Alex; McDermott, Robyn (2015) 'Does Strongyloides stercoralis infection protect against type 2 diabetes in humans? Evidence from Australian Aboriginal adults'. Diabetes Research and Clinical Practice, 107 (3):355-361. [DOI]
Journal Publication
ResearchOnline@JCU
Stoll, Richard; Urban-Klein, Beata; Giacomin, Paul; Loukas, Alex; Jablonski-Momeni, Anahita (2015) 'In vivo assessment of caries excavation with a fluorescence camera compared to direct bacteriological sampling and quantitative analysis using flow cytometry'. Lasers in Medical Science, 30 (2):843-849. [DOI]
Journal Publication
ResearchOnline@JCU
Smout, Michael J.; Sotillo, Javier; Laha, Thewarach; Papatpremsiri, Atiroch; Rinaldi, Gabriel; Pimenta, Rafael N.; Chan, Lai Yue; Johnson, Michael S.; Turnbull, Lynne; Whitchurch, Cynthia B.; Giacomin, Paul R.; Moran, Corey S.; Golledge, Jonathan; Daly, Norelle; Sripa, Banchob; Mulvenna, Jason P.; Brindley, Paul J.; Loukas, Alex (2015) 'Carcinogenic parasite secretes growth factor that accelerates wound healing and potentially promotes neoplasia'. PLoS Pathogens, 11 (10):1-20. [DOI]
The intestinal microbiota contributes to the ability of helminths to modulate allergic inflammation
2015
Zaiss, Mario M.; Rapin, Alexis; Lebon, Luc; Dubey, Lalit Kumar; Mosconi, Ilaria; Sarter, Kerstin; Piersigilli, Alessandra; Menin, Laure; Walker, Alan W.; Rougemont, Jacques; Paerewijck, Oonagh; Geldhof, Peter; McCoy, Kathleen D.; Macpherson, Andrew J.; Croese, John; Giacomin, Paul R.; Loukas, Alex; Junt, Tobias; Marsland, Benjamin J.; Harris, Nicola L. (2015) 'The intestinal microbiota contributes to the ability of helminths to modulate allergic inflammation'. Immunity, 43 (5):998-1010. [DOI]
Giacomin, Paul; Croese, John; Krause, Lutz; Loukas, Alex; Cantacessi, Cinzia (2015) 'Suppression of inflammation by helminths: a role for the gut microbiota'. Philosophical Transactions of the Royal Society B: Biological Sciences, 370 (1675):1-6. [DOI]
Giacomin, Paul R.; Moy, Ryan H.; Noti, Mario; Osborne, Lisa C.; Siracusa, Mark C.; Alenghat, Theresa; Liu, Bigang; McCorkell, Kelly A.; Troy, Amy E.; Rak, Gregory D.; Hu, Yinling; May, Michael J.; Ma, Hak-Ling; Fouser, Lynette A.; Sonnenberg, Gregory F.; Artis, David (2015) 'Epithelial-intrinsic IKKα expression regulates group 3 innate lymphoid cell responses and antibacterial immunity'. The Journal of Experimental Medicine, 212 (10):1513-1528. [DOI]
Giacomin, Paul; Zakrzewski, Martha; Croese, John; Su, Xiaopei; Sotillo, Javier; McCann, Leisa; Navarro, Severine; Mitreva, Makedonka; Krause, Lutz; Loukas, Alex; Cantacessi, Cinzia (2015) 'Experimental hookworm infection and escalating gluten challenges are associated with increased microbial richness in celiac subjects'. Scientific Reports, 5 :1-8. [DOI]
Tribolet, Leon; Cantacessi, Cinzia; Pickering, Darren; Navarro, Severine; Doolan, Denise; Trieu, Angela; Fei, Huang; Chao, Yang; Hofmann, Andreas; Gasser, Robin; Giacomin, Paul; Loukas, Alex (2015) 'Probing of a human proteome microarray with a recombinant pathogen protein reveals a novel mechanism by which hookworms suppress B-cell receptor signaling'. Journal of Infectious Diseases, 211 (3):416-425. [DOI]
Journal Publication
ResearchOnline@JCU
Croese, John; Giacomin, Paul; Navarro, Severine; Clouston, Andrew; McCann, Leisa; Dougall, Annette; Ferreira, Ivana; Susianto, Atik; O'Rourke, Peter; Howlett, Mariko; McCarthy, James; Engwerda, Christian; Jones, Dianne; Loukas, Alex (2015) 'Experimental hookworm infection and gluten microchallenge promote tolerance in celiac disease'. Journal of Allergy and Clinical Immunology, 135 (2):508-516. [DOI]
Journal Publication
ResearchOnline@JCU
Sotillo, Javier; Sanchez-Flores, Alejandro; Cantacessi, Cinzia; Harcus, Yvonne; Pickering, Darren; Bouchery, Tiffany; Camberis, Mali; Tang, Shiau-Choot; Giacomin, Paul; Mulvenna, Jason; Mitreva, Makedonka; Berriman, Matthew; LeGros, Graham; Maizels, Rick M.; Loukas, Alex (2014) 'Secreted proteomes of different developmental stages of the gastrointestinal nematode Nippostrongylus brasiliensis'. Molecular and Cellular Proteomics, 13 (10):2736-2751. [DOI]
Journal Publication
ResearchOnline@JCU
Cantacessi, Cinzia; Giacomin, Paul; Croese, John; Zakrzewski, Martha; Sotillo, Javier; McCann, Leisa; Nolan, Matthew J.; Mitreva, Makedonka; Krause, Lutz; Loukas, Alex (2014) 'Impact of experimental hookworm infection on the human gut microbiota'. Journal of Infectious Diseases, 210 (9):1431-1434. [DOI]
Sawant, Deepali V.; Gravano, David M.; Vogel, Peter; Giacomin, Paul; Artis, David; Vignali, Dario A.A. (2014) 'Regulatory T cells limit induction of protective immunity and promote immune pathology following intestinal helminth infection'. Journal of Immunology, 192 (6):2904-2912. [DOI]
Journal Publication
ResearchOnline@JCU
Osborne, Lisa C.; Joyce, Karen L.; Alenghat, Theresa; Sonnenberg, Gregory F.; Giacomin, Paul R.; Du, Yurong; Bergstrom, Kirk S.; Vallance, Bruce A.; Nair, Meera G. (2013) 'Resistin-like molecule α promotes pathogenic Th17 cell responses and bacterial-induced intestinal inflammation'. Journal of Immunology, 190 (5):2292-2300. [DOI]
Journal Publication
ResearchOnline@JCU
Noti, Mario; Tait Wojno, Elia D.; Kim, Brian S.; Siracusa, Mark C.; Giacomin, Paul R.; Nair, Meera G.; Benitez, Alain J.; Ruymann, Kathryn R.; Muir, Amanda B.; Hill, David A.; Chikwava, Kudakwashe R.; Moghaddam, Amin E.; Sattentau, Quentin J.; Alex, Aneesh; Zhou, Chao; Yearley, Jennifer H.; Menard-Katcher, Paul; Kubo, Masato; Obata-Ninomiya, Kazushige; Karusuyama, Hajime; Comeau, Michael R.; Brown-Whitehorn, Terri; de Waal Malefyt, Rene; Sleiman, Patrick M.; Hakonarson, Hakon; Cianferoni, Antonella; Falk, Gary W.; Wang, Mei-Lun; Spergel, Jonathan M.; Artis, David (2013) 'Thymic stromal lymphopoietin–elicited basophil responses promote eosinophilic esophagitis'. Nature Medicine, 19 (8):1005-1013. [DOI]
Journal Publication
ResearchOnline@JCU
Ferreira, Ivana; Smyth, Danielle; Gaze, Soraya; Aziz, Ammar; Giacomin, Paul; Ruyssers, Nathalie; Artis, David; Laha, Thewarach; Navarro, Severine; Loukas, Alex; McSorley, Henry J. (2013) 'Hookworm excretory/secretory products induce interleukin-4 (IL-4)+ IL-10+ CD4+ T cell responses and suppress pathology in a mouse model of colitis'. Infection and Immunity, 81 (6):2104-2111. [DOI]
Journal Publication
ResearchOnline@JCU
Alenghat, Theresa; Osborne, Lisa C.; Saenz, Steven A.; Kobuley, Dmytro; Ziegler, Carly G.K.; Mullican, Shannon E.; Choi, Inchan; Grunberg, Stephanie; Sinha, Rohini; Wynosky-Dolfi, Meghan; Snyder, Annelise; Giacomin, Paul R.; Joyce, Karen L.; Hoang, Tram B.; Bewtra, Meenakshi; Brodsky, Igor E.; Sonnenberg, Gregory F.; Bushman, Frederic D.; Won, Kyoung-Jae; Lazar, Mitchell A.; Artis, David (2013) 'Histone deacetylase 3 coordinates commensal-bacteria-dependent intestinal homeostasis'. Nature, 504 :153-157. [DOI]
Journal Publication
ResearchOnline@JCU
Giacomin, Paul R.; Siracusa, Mark C.; Walsh, Kevin P.; Grencis, Richard K.; Kubo, Masato; Comeau, Michael R.; Artis, David (2012) 'Thymic stromal lymphopoietin-dependent basophils promote Th2 cytokine responses following intestinal helminth infection'. Journal of Immunology, 189 (9):4371-4378. [DOI]
Journal Publication
ResearchOnline@JCU
Mullican, Shannon E.; Gaddis, Christine A.; Alenghat, Theresa; Nair, Meera G.; Giacomin, Paul R.; Everett, Logan J.; Feng, Dan; Steger, David J.; Schug, Jonathan; Artis, David; Lazar, Mitchell A. (2011) 'Histone deacetylase 3 is an epigenomic brake in macrophage alternative activation'. Genes & Development, 25 (23):2480-2488. [DOI]
Journal Publication
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Collison, Lauren W.; Chaturvedi, Vandana; Henderson, Abigail L.; Giacomin, Paul; Guy, Cliff; Bankoti, Jaishree; Finkelstein, David; Forbes, Karen; Workman, Creg J.; Brown, Scott A.; Rehg, Jerold E.; Jones, Michael L.; Ni, Hsiao-Tzu; Artis, David; Turk, Mary Jo; Vignali, Dario A.A. (2010) 'IL-35-mediated induction of a potent regulatory T cell population'. Nature Immunology, 11 (12):1093-1101. [DOI]
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MHC class II-dependent basophil-CD4+ T cell interactions promote T(H)2 cytokine-dependent immunity
2009
Perrigoue, Jacqueline G.; Saenz, Steven A.; Siracusa, Mark C.; Allenspach, Eric J.; Taylor, Betsy C.; Giacomin, Paul R.; Nair, Meera G.; Du, Yurong; Zaph, Colby; van Rooijen, Nico ; Comeau, Michael R.; Pearce, Edward J.; Laufer, Terri M.; Artis, David (2009) 'MHC class II-dependent basophil-CD4+ T cell interactions promote T(H)2 cytokine-dependent immunity'. Nature Immunology, 10 (7):697-705. [DOI]
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Giacomin, P.R.; Cava, M.; Tumes, D.J.; Gauld, A.D.; Iddawela, D.; McColl, S.R.; Parsons, J.C.; Gordon, D.L.; Dent, L.A. (2008) 'Toxocara canis larval excretory/secretory proteins impair eosinophil-dependent resistance of mice to Nippostrongylus brasiliensis'. Parasite Immunology, 30 (8):435-445. [DOI]
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Giacomin, Paul R.; Gordon , David L.; Botto, Marina; Daha, Mohamed R.; Sanderson, Sam D.; Taylor, Stephen M.; Dent, Lindsay A. (2008) 'The role of complement in innate, adaptive and eosinophil-dependent immunity to the nematode Nippostrongylus brasiliensis'. Molecular Immunology, 45 (2):446-455. [DOI]
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Knott, Michelle L.; Matthaei, Klaus I.; Giacomin, Paul; Wang, Hui; Foster, Paul S.; Dent, Lindsay A. (2007) 'Impaired resistance in early secondary Nippostrongylus brasiliensis infections in mice with defective eosinophilopoeisis'. International Journal for Parasitology, 37 (12):1367-1378. [DOI]
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Giacomin, Paul R.; Wang, Hui; Gordon, David L.; Botto, Marina; Dent, Lindsay A. (2005) 'Loss of complement activation and leukocyte adherence as Nippostrongylus brasiliensis develops within the murine host'. Infection and Immunity, 73 (11):7442-7449. [DOI]
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Keating, Damien; Rychkov, Grigori; Giacomin, Paul; Roberts, Michael (2005) 'Oxygen-sensing pathway for SK channels in the ovine adrenal medulla'. Clinical and Experimental Pharmacology & Physiology, 32 (10):882-887. [DOI]
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Giacomin, Paul R.; Wang, Hui; Gordon, David L.; Dent, Lindsay A. (2004) 'Quantitation of complement and leukocyte binding to a parasitic helminth species'. Journal of Immunological Methods, 289 (1-2):201-210. [DOI]
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McKay, Darrin; Brooker, Raylene; Giacomin, Paul; Ridding, Michael; Miles, Timothy (2002) 'Time course of induction of increased human motor cortex excitability by nerve stimulation'. Neuroreport, 13 (10):1271-1273.
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Kamath, Sandip D.; Liu, Tiange; Giacomin, Paul; Loukas, Alex; Navarro, Severine; Lopata, Andreas L. (2022) 'Mollusk allergy: Not simply cross-reactivity with crustacean allergens' Allergy, 77 (10) :3127-3130. [DOI]
Filbey, Kara J.; Finney, Constance A.M.; Giacomin, Paul R.; Siracusa, Mark C. (2021) 'Editorial: Recent advances in the immunology of helminth infection – protection, pathogenesis and panaceas' Frontiers in Immunology, 12 . [DOI]
Hays, Russell; Pierce, Doris; Giacomin, Paul; Loukas, Alex; Bourke, Peter; McDermott, Robyn (2020) 'Helminth coinfection and COVID-19: an alternate hypothesis' PLoS Neglected Tropical Diseases, 14 (8) . [DOI]
Ruscher, Roland; Giacomin, Paul (2020) 'IL-17A moonlighting in lung type 2 immunity' Mucosal Immunology, 13 :849-851. [DOI]
Journal Contribution
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Pierce, Doris; Merone, Lea; Lewis, Chris; Rahman, Tony; Croese, John; Loukas, Alex; McDonald, Malcolm; Giacomin, Paul; McDermott, Robyn (2019) 'Safety and tolerability of experimental hookworm infection in humans with metabolic disease: study protocol for a phase 1b randomised controlled clinical
trial' BMC Endocrine Disorders, 19 . [DOI]
Giacomin, Paul; Agha, Zainab; Loukas, Alex (2016) 'Helminths and intestinal flora team up to improve gut health' Trends in Parasitology, 32 (9) :664-666. [DOI]
Journal Contribution
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Loukas, Alex; Giacomin, Paul (2016) 'Developments in the design of anti-helminth vaccines' In: Loukas, Alex, and Giacomin, Paul (2016) Developments in the design of anti-helminth vaccines. In: Gause, William C., and Artis, David, (eds.) The Th2 Type Immune Response in Health and Disease: from host defense and allergy to metabolic homeostasis and beyond. Springer, New York, NY, USA, pp. 97-114(Eds.). The Th2 Type Immune Response in Health and Disease: from host defense and allergy to metabolic homeostasis and beyond. New York, NY, USA : Springer. [DOI]
Book Chapter
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