Preclinical evaluation of novel drug lead compounds discovered from Wet Tropics plant (Old ID 28949)

Chief Investigator

Inflammatory bowel disease (IBD) affects 1 in 250 Australians including the people living in Far North Queensland (FNQ). There is no cure for this debilitating disease. Inspired by the Wet Tropics, we have isolated two compounds that demonstrated strong in vitro anti-inflammatory activity. A provisional patent has been approved for these two compounds. To further develop them into the marketable drug lead candidates, this proposed project will endeavor to achieve preclinical evaluation of these two novel compounds using the two commonly used animal models of IBD- Trinitrobenzenesulfonic acid (TNBS) and T cell transfer models of colitis.

01 Jan 2023 - 15 Sep 2025

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