Exploring new therapeutic approaches for coeliac disease based on biological effects of hookworm treatment. (Old ID 27271)

Principal Investigator

We hypothesise that hookworm infection creates an anti-inflammatory environment in the small intestine that favours improved gluten intolerance in coeliac disease, and undersstanding the biological mechanisms that lead to improved gluten intolerance will advance the development of novel theraplies that will not require being infected with live worms. The overall aim of this project is to comprehensively profile the biological responses in the gut and faeces using innovative, complementary techniques (RNA-sequencing, transcriptomic imaging and microbiome analyses) and correlate these changes with improved coeliac disease outcomes.

01 May 2021 - 30 Nov 2022

N/A