Medicine
Tao (Daniel) Xing
- JCU Associate Professor
- daniel.xing@jcu.edu.au
Melissa Crowe
- JCU Associate Professor
- melissa.crowe@jcu.edu.au
Mal Fernando
- Adjunct Research Fellow
- mal.fernando@jcu.edu.au
Priscilla Page
- Indigenous Health Academic
- priscilla.page1@jcu.edu.au
Joseph Moxon
- Principal Research Fellow
- joseph.moxon@jcu.edu.au
Jonathan Golledge
- Distinguished Professor
- jonathan.golledge@jcu.edu.au
Jodie Morris
- Adjunct Senior Research Fellow
- jodie.morris1@jcu.edu.au
Zaf Smith
- Associate Professor, Medical Education
- zaf.smith@jcu.edu.au
Torres Woolley
- Senior Lecturer
- torres.woolley@jcu.edu.au
Aaron Drovandi
- Adjunct Research Fellow
- aaron.drovandi@jcu.edu.au
(COMFITE) Efficacy, acceptability and adherence with custom-made footwear in people with a history of diabetes-related foot disease. (Old ID 26968)
Approximately 8% (n=80,000) of Northern Australians have diabetes of whom about a quarter (n=20,000) will develop foot disease putting them at risk of amputation and death and costing ~$24 million each year. The most common cause of diabetes-related foot complications is excessive pressure on an area of an insensate foot. Footwear designed to limit pressure on the feet has been shown to reduce the risk of foot ulcers. The most appropriate type of footwear is however unknown. This pilot clinical trial examines the efficacy and acceptability of footwear designed to the shape of an individuals’ feet using three-dimensional printing.
Proposed development of revised framework for operational and implementation research in health and disease control programmes. (Old ID 27222)
Strong, responsive and resilient health systems are the critical foundation for global health security. Health systems depend on effective functioning of both people and networks in order to implement effective disease control programmes, detect and respond quickly to infectious disease threats and develop evidence-informed policy/practice. The purpose of this work is to develop a revised framework for operational and implementation research (OR/IR) in health and disease control programs. This framework can be used to develop adequate and sustainable OR/IR capacity in public health programs and create an organisational culture of policy and practice that is informed by evidence-informed decision making.
Proposed development of revised framework for operational and implementation research in health and disease control programmes. (Old ID 27222)
Strong, responsive and resilient health systems are the critical foundation for global health security. Health systems depend on effective functioning of both people and networks in order to implement effective disease control programmes, detect and respond quickly to infectious disease threats and develop evidence-informed policy/practice. The purpose of this work is to develop a revised framework for operational and implementation research (OR/IR) in health and disease control programs. This framework can be used to develop adequate and sustainable OR/IR capacity in public health programs and create an organisational culture of policy and practice that is informed by evidence-informed decision making.
Assessment of the efficacy of a novel treatment for Peripheral Artery Disease (PAD) (Old ID 26206)
Blockage of leg arteries (peripheral artery disease - PAD) leads to severe exertional leg pain (intermittent claudication), impaired walking ability, reduced health-related quality of life, and high risk of amputation and death. Multiple lines of evidence suggest that metformin, a cheap and safe medication, promotes formation of new vessels, improves microcirculation and muscle function,s and limits pain.
Design, implementation, and evaluation of an intervention for a kidney transplant service in northern Queensland (Phase 2)
This study will explore the experiences of kidney transplant recipients and health professionals, perceived barriers to transplantation and ways in which patient experiences could be improved. This data will inform the design of an intervention for the proposed new kidney transplant service for northern Queensland, which will be implemented and evaluated using a prospective cohort study. The expected outcome of this study is that the intervention will influence the development and provision of clinical services for the northern Queensland kidney transplant service, improving patient experiences and clinical outcomes.
Metformin in the management of abdominal aortic aneurysm (MAGIC) (Old ID 25135)
MAGIC will be the first trial to assess the value of metformin wiuth significant preliminary data to suggest it can slow AAA growth. This trial offers the possibility of identifying a new treatment modality for an increasingly common condition, which would markedly change clinical practice.
Tele-DFD: Remotely providing effective healthcare for diabetic foot disease (Old ID 27644)
Current models of care for diabetes-associated foot disease (DFD) management are not sustainable due to the recurring nature of this condition and lead to enormous social and economic burden (~$24 million / year). Models of healthcare that are financially viable and effective at meeting the challenges of the dispersed population of Northern Australia are urgently needed to reduce the rates of DFD-related amputations, and costs associated with preventable hospital admissions and ongoing treatment. This project will test whether a telehealth model of care (Tele-DFD) is more effective at achieving secondary prevention than the current usual face to face consultation model. If effective this model offers the potential of improved health outcomes and substantially reducing geographic disparity and social and economic burden from DFD.
Women's Action for Mums and Bubs (WOMB): A pragmatic trial of participatory women's groups to improve Indigenous maternal and child health (Old ID 23276)
There is strong evidence elsewhere that involving community women in decision-making about strategies to improve the health of mothers and babies is a cheap and effective way of improving health. The WOMB study tests whether community women's groups improve the quality of maternal and child health care and outcomes in Aboriginal and Torres Strait Islander communities, the cost-effectiveness and mechanism of action.
Testing a novel treatment for diabetes-associated ischemic foot ulceration. (Old ID 24978)
5000 Australians with diabetes have a leg amputations each year. This project investigates a novel drug therapy approach to reducing the need for leg amputations within an established rodent model. The aim of the study is to assess if administration of a direct activator of adenosine-5'-monophosphate (AMP)-activated protein kinase (AMPK) will promote healing within a rat model of diabetes and limb ischaemia-associated foot ulceration.
Metformin for treating peripheral artery disease-related walking impairment (MERIT) (Old ID 24975)
Blockage of the lower limb arteries (peripheral artery disease; PAD) leads to severe leg pain, walking impairment, and a substantial risk of leg amputation and death. Approximately 200 million people worldwide and approximately 1 million Australians have blocked leg arteries. This problem has recognised treatment deficiencies in comparison to other common diseases, including the absence of effective medications to increase blood supply to the legs, reduce leg pain, improve walking ability and reduce the risk of major amputation. Multiple lines of evidence suggest that metformin, a cheap and safe medication, promotes formation of new vessels, improves microcirculation and muscle function, and limits pain. In preliminary studies, metformin significantly increased blood supply to the limb of a pre-clinical model of blocked leg arteries. We have also associated metformin prescription with a 4-fold reduction in the rate of major lower limb amputation in patients with blocked arteries. This placebo-controlled, randomised clinical trial will examine the efficacy of metformin in improving walking ability in patients with blocked leg arteries over 6 months. Positive findings from this trial will identify a new treatment for a problem that affects 10-20% of adults aged over 50 years.
Association of osteoprotegerin with human abdominal aortic aneurysm progression
- 2005
- American Heart Association
- Researchers:Jonathan Golledge
The small abdominal aortic aneurysm
- 2007
- Edizioni Minerva Medica
- Researchers:Jonathan Golledge
Matrix Biology of Abdominal Aortic Aneurysms in Diabetes: Mechanisms Underlying the Negative Association
- 2007
- Informa Healthcare
- Researchers:Jonathan Golledge
The outcome of endovascular repair of small abdominal aortic aneurysms
- 2007
- Lippincott Williams & Wilkins
- Researchers:Jonathan Golledge
Association between osteopontin and human abdominal aortic aneurysm
- 2007
- Lippincott, Williams & Wilkins
- Researchers:Jonathan Golledge
Obesity, adipokines, and abdominal aortic aneurysm: health in men study
- 2007
- American Heart Association
- Researchers:Jonathan Golledge
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01 Jan 2012
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01 Jan 2012
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01 Jan 2009
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01 Jan 2009
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01 Jan 2007
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01 Jan 2002
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01 Jan 2002
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01 Jan 1996
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01 Jan 2002
End Date:
01 Jan 2009
Start Date:
01 Jan 2003
End Date:
01 Jan 2004