Lionel Hebbard
- lionel.hebbard@jcu.edu.au
https://orcid.org/0000-0002-7094-9065- Associate Professor
- Molecular and Cell Biology
Projects
0
Publications
59
Awards
0
Contact Details
Associate Professor
Research
Research Interests
Hepatocellular carcinoma and therapeutic approaches
Muscle development and disease
Cancer Stem Cells
Research Collaborators and Partners
Queensland University of Technology
The University of Sydney
Teaching
Teaching Interests
Cancer Biology and Biochemistry
Research Advisor Accreditation
Advisor Type
Mentor
Research Advisor Accreditation
Role
Chair; Independent Academic
Taught Modules
2026
2025
2025
Available Projects
Developing new proteins through precision fermentation - Molecular and Cell Biology
Date Added
30 Mar 2026Investigating new genes and therapies in Liver Cancer - Molecular Genetics
Date Added
11 Oct 2024Output
Wankell, Miriam; Hebbard, Lionel (2023) Testing Cell Migration, Invasion, Proliferation, and Apoptosis in Hepatic Stellate Cells. New York, NY, USA: [Non-Research Book Chapter] [DOI]
Other Publication
ResearchOnline@JCU
Nezafati, Pouya; Saxena, Pankaj; Raman, Jaishankar; Hebbard, Lionel; Draper, Narelle; McFarlane, Craig (2026) 'Quantification of Sarcopenia using Chest Computed Tomography of the Pectoralis Major Muscle as a Prognostic Tool for Cardiac Surgery Outcomes'. Heart, Lung and Circulation, . [DOI]
Rezaeivandchali, Noushin; Hebbard, Lionel; McFarlane, Craig (2026) 'Collagen Biomaterials: From Traditional Animal Sources to Marine and Recombinant Alternatives'. International Journal of Biomaterials, 2026 . [DOI]
From Cell Line to Fillet: A Review of Biological and Engineering Strategies in Cultivated Seafood
2026
Trace, Angela; Wankell, Miriam; McFarlane, Craig; Hebbard, Lionel (2026) 'From Cell Line to Fillet: A Review of Biological and Engineering Strategies in Cultivated Seafood'. Food Bioengineering, . [DOI]
Trace, Craig; Wankell, Miriam; McFarlane, Craig; Hebbard, Lionel (2026) 'Characterisation of Lates calcarifer primary myoblast proliferation and differentiation from direct cell isolation'. In Vitro Cellular and Developmental Biology: animal, . [DOI]
Journal Publication
ResearchOnline@JCU
Nezafati, Pouya; Saxena, Pankaj; Raman, Jaishankar; Hebbard, Lionel; McFarlane, Craig (2025) 'Getting to the heart of sarcopenia and cardiovascular disease'. Aging-US, . [DOI]
A New Model to Investigate the Action of Radiation and Cigarette Smoke on Head and Neck Cancer Cells
2025
Lopes Floro, Kylie; Gillman, Rhys; Wankell, Miriam; Dewdney, Brittany; Chilkuri, Madhavi; Shackelford, Ashley; Kuma, Leslie; Powers, Marcus; Hebbard, Lionel (2025) 'A New Model to Investigate the Action of Radiation and Cigarette Smoke on Head and Neck Cancer Cells'. Cancers, 17 . [DOI]
Trace, Angela; Wankell, Miriam; McFarlane, Craig; Hebbard, Lionel (2025) 'The challenges of using fish cells for cultivated seafood production'. Food Science and Biotechnology, 34 :1565-1579. [DOI]
Journal Publication
ResearchOnline@JCU
TARGET-SL: precision essential gene prediction using driver prioritisation and synthetic lethality
2025
Gillman, Rhys; Schmitz, Ulf; Field, Matt A.; Hebbard, Lionel (2025) 'TARGET-SL: precision essential gene prediction using driver prioritisation and synthetic lethality'. Briefings in Bioinformatics, 26 (3). [DOI]
Gillman, Rhys; Field, Matt A.; Schmitz, Ulf; Karamatic, Rozemary; Hebbard, Lionel (2023) 'Identifying cancer driver genes in individual tumours'. Computational and Structural Biotechnology Journal, 21 :5028-5038. [DOI]
Dorney, Ryley; Dhungel, Bijay P.; Rasko, John E.J.; Hebbard, Lionel; Schmitz, Ulf (2023) 'Recent Advances in Cancer Fusion Transcript Detection'. Briefings in Bioinformatics, 24 (1). [DOI]
Harkus, Uasim; Wankell, Miriam; Palamuthusingam, Pranavan; McFarlane, Craig McFarlane; Hebbard, Lionel (2022) 'Immune checkpoint inhibitors in HCC: Cellular, molecular and systemic data'. Seminars in Cancer Biology, 86 (3):799-815. [DOI]
Journal Publication
ResearchOnline@JCU
Zhou, Gang; Da Won Bae, Sarah; Nguyen, Romario; Huo, Xiaoqi; Han, Shuanglin; Zhang, Zhiqiang; Hebbard, Lionel; Duan, Wei; Eslam, Mohammed; Liddle, Christopher; Yuen, Lawrence; Lam, Vincent; Qiao, Liang; George, Jacob (2021) 'An aptamer-based drug delivery agent (CD133-apt-Dox) selectively and effectively kills liver cancer stem-like cells'. Cancer Letters, 501 :124-132. [DOI]
Journal Publication
ResearchOnline@JCU
Taylor, Lauren; Wankell, Miriam; Saxena, Pankaj; McFarlane, Craig McFarlane; Hebbard, Lionel (2021) 'Cell adhesion an important determinant of myogenesis and satellite cell activity'. Biochimica et Biophysica Acta. Molecular Cell Research, 1869 (2). [DOI]
Journal Publication
ResearchOnline@JCU
Sun, Eun Jin; Wankell, Miriam; Palamuthusingam, Pranavan; McFarlane, Craig; Hebbard, Lionel (2021) 'Targeting the PI3K/Akt/mTOR pathway in hepatocellular carcinoma'. Biomedicines, 9 (11). [DOI]
Gillman, Rhys; Lopes Floro, Kylie; Wankell, Miriam; Hebbard, Lionel (2020) 'The role of DNA damage and repair in liver cancer'. Biochimica et Biophysica Acta Reviews on Cancer, 1875 (1). [DOI]
Journal Publication
ResearchOnline@JCU
Dewdney, Brittany; Alanzay, Mohammed; Gillman, Rhys; Walker, Sarah; Wankell, Miriam; Qiao, Liang; George, Jacob; Roberts, Alex; Hebbard, Lionel (2020) 'The effects of fructose and metabolic inhibition on hepatocellular carcinoma'. Scientific Reports, 10 . [DOI]
Dewdney, Brittany; Roberts, Alexandra; Qiao, Liang; George, Jacob; Hebbard, Lionel (2020) 'A sweet connection? Fructose’s role in hepatocellular carcinoma'. Biomolecules, 10 (4). [DOI]
Walker, Sarah; Wankell, Miriam; White, Rose; Ho, Vikki; Deo, Nikita; Devine, Carol; Dewdney, Brittany; Bhathal, Prithi; Govaere, Olivier; Roskams, Tania; Qiao, Liang; George, Jacob; Hebbard, Lionel (2019) 'Targeting mTOR and Src restricts hepatocellular carcinoma growth in a novel murine liver cancer model'. PLoS One, 14 (2). [DOI]
Gupta, Sunil; Read, Scott A.; Shackel, Nicholas A.; Hebbard, Lionel; George, Jacob; Ahlenstiel, Golo (2019) 'The role of micronutrients in the infection and subsequent response to hepatitis C virus'. Cells, 8 (6). [DOI]
Kreuter, Roxane; Wankell, Miriam; Ahlenstiel, Golo; Hebbard, Lionel (2019) 'The role of obesity in inflammatory bowel disease'. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1865 (1):63-72. [DOI]
Journal Publication
ResearchOnline@JCU
Aptamers as targeting ligands and therapeutic molecules for overcoming drug resistance in cancers
2018
Zhou, Gang; Latchoumanin, Olivier; Hebbard, Lionel; Duan, Wei; Liddle, Christopher; George, Jacob; Qiao, Liang (2018) 'Aptamers as targeting ligands and therapeutic molecules for overcoming drug resistance in cancers'. Advanced Drug Delivery Reviews, 134 :107-121. [DOI]
Journal Publication
ResearchOnline@JCU
Alzahrani, Badr; Iseli, Tristan; Ramezani-Moghadam, Mehdi; Ho, Vikki; Wankell, Miriam; Sun, Eun Jin; Qiao, Liang; George, Jacob; Hebbard, Lionel W. (2018) 'The role of AdipoR1 and AdipoR2 in liver fibrosis'. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1864 (3):700-708. [DOI]
Wu, Guang; Wilson, George; George, Jacob; Liddle, Christopher; Hebbard, Lionel; Liang, Qiao (2017) 'Overcoming treatment resistance in cancer: current understanding and tactics'. Cancer Letters, 387 :69-76. [DOI]
Journal Publication
ResearchOnline@JCU
Huo, Xiaoqi; Han, Shuanglin; Wu, Guang; Latchoumanin, Oliveir; Zhou, Gang; Hebbard, Lionel; George, Jacob; Qiao, Liang (2017) 'Dysregulated long noncoding RNAs(lncRNAs) in hepatocellular carcinoma: implications for tumorigenesis, disease progression, and liver cancer stem cells'. Molecular Cancer, 16 . [DOI]
Obeid, Stephanie; Wankell, Miriam; Charrez, Berenice; Sternberg, Jade; Kreuter, Roxane; Esmaili, Saeed; Ramezani-Moghadam, Mehdi; Devine, Carol; Read, Scott; Bhathal, Prithi; Lopata, Andreas; Ahlenstiel, Golo; Qiao, Liang; George, Jacob; Hebbard, Lionel (2017) 'Adiponectin confers protection from acute colitis and restricts a B cell immune response'. Journal of Biological Chemistry, 292 (16):6569-6582. [DOI]
Journal Publication
ResearchOnline@JCU
Recent clinical trials utilizing chimeric antigen receptor T cells therapies against solid tumors
2017
Han, Shuanglin; Latchoumanin, Olivier; Wu, Guang; Zhou, Gang; Hebbard, Lionel; George, Jacob; Qiao, Liang (2017) 'Recent clinical trials utilizing chimeric antigen receptor T cells therapies against solid tumors'. Cancer Letters, 390 :188-200. [DOI]
Journal Publication
ResearchOnline@JCU
Sternberg, Jade; Wankell, Miriam; Subramaniam, V. Nathan; Hebbard, Lionel (2017) 'The functional roles of T-cadherin in mammalian biology'. AIMS Molecular Science, 4 (1):62-81. [DOI]
Zhou, Gang; Latchoumanin, Olivier; Bagdesar, Mary; Hebbard, Lionel; Duan, Wei; Liddle, Christopher; George, Jacob; Qiao, Liang (2017) 'Aptamer-based therapeutic approaches to target cancer wtem cells'. Theranostics, 7 (16):3948-3961. [DOI]
Zhou, Gang; Wilson, George; Hebbard, Lionel; Duan, Wei; Liddle, Christopher; George, Jacob; Qiao, Liang (2016) 'Aptamers: a promising chemical antibody for cancer therapy'. Oncotarget, 7 (12):13446-13463. [DOI]
Charrez, Bérénice; Qiao, Liang; Hebbard, Lionel (2016) 'Hepatocellular carcinoma and non-alcoholic steatohepatitis: the state of play'. World Journal of Gastroenterology, 22 (8):2494-2502. [DOI]
Wu, Guang; Wilson, George; Zhou, Gang; Hebbard, Lionel; George, Jacob; Qiao, Liang; ; (2015) 'Oct4 is a reliable marker of liver tumor propagating cells in hepatocellular carcinoma'. Discovery Medicine, 20 (110):219-229.
Journal Publication
ResearchOnline@JCU
Charrez, Bérénice; Qiao, Liang; Hebbard, Lionel (2015) 'The role of fructose in metabolism and cancer'. Hormone molecular biology and clinical investigation, 22 (2):79-89. [DOI]
Journal Publication
ResearchOnline@JCU
Heebøll, Sara; Thomsen, Karen Louise; Clouston, Andrew; Sundelin, Elias Immanuel; Radko, Yulia; Christensen, Lars Porskjær; Ramezani-Moghadam, Mehdi; Kreutzfeldt, Martin; Pedersen, Steen Bønløkke; Jessen, Niels; Hebbard, Lionel; George, Jacob; Grønbæk, Henning (2015) 'Effect of resveratrol on experimental non-alcoholic steatohepatitis'. Pharmacological research, 95-96 :34-41. [DOI]
Journal Publication
ResearchOnline@JCU
Ramezani-Moghadam, Mehdi; Wang, Jianhua; Ho, Vikki; Iseli, Tristan J.; Alzahrani, Badr; Xu, Aimin; Van der Poorten, David; Qiao, Liang; George, Jacob; Hebbard, Lionel (2015) 'Adiponectin reduces hepatic stellate cell migration by promoting tissue inhibitor of metalloproteinase-1 (TIMP-1) secretion'. Journal of Biological Chemistry, 290 (9):5533-5542. [DOI]
Journal Publication
ResearchOnline@JCU
Alzahrani, Badr; Iseli, Tristan J.; Hebbard, Lionel W. (2014) 'Non-viral causes of liver cancer: does obesity led inflammation play a role'. Cancer Letters, 345 (2):223-229. [DOI]
Journal Publication
ResearchOnline@JCU
Jiang, Chun-Meng; Pu, Chun-Wen; Hou, Ya-Hui; Chen, Zhe; Alanazy, Mohammed; Hebbard, Lionel (2014) 'Non alcoholic steatohepatitis a precursor for hepatocellular carcinoma development'. World Journal of Gastroenterology, 20 (44):16464-16473. [DOI]
Journal Publication
ResearchOnline@JCU
Tian, Aiping; Wilson, George S.; Lie, Stefanus; Wu, Guang; Hu, Zenan; Hebbard, Lionel; Duan, Wei; George, Jacob; Qiao, Liang (2014) 'Synergistic effects of IAP inhibitor LCL161 and paclitaxel on hepatocellular carcinoma cells'. Cancer Letters, 351 (2):232-241. [DOI]
Journal Publication
ResearchOnline@JCU
Thomsen, Karen Louise; Grønbæk, Henning; Glavind, Emilie; Hebbard, Lionel; Jessen, Niels; Clouston, Andrew; George, Jacob; Vilstrup, Hendrik (2014) 'Experimental nonalcoholic steatohepatitis compromises ureagenesis, an essential hepatic metabolic function'. Gastrointestinal and liver physiology, 307 (3):G295-G301. [DOI]
Journal Publication
ResearchOnline@JCU
Thomsen, Karen L.; Hebbard, Lionel; Glavind, Emilie; Clouston, Andrew; Vilstrup, Hendrik; George, Jacob; Grønbæk, Henning (2014) 'Non-alcoholic steatohepatitis weakens the acute phase response to endotoxin in rats'. Liver international, 34 (10):1584-1592. [DOI]
Journal Publication
ResearchOnline@JCU
Dai, Yun; Jiao, Hongmei; Teng, Guigen; Wang, Weihong; Zhang, Rongxin; Wang, Yunhong; Hebbard, Lionel; George, Jacob; Qiao, Liang (2014) 'Embelin reduces colitis-associated tumorigenesis through limiting IL-6/STAT3 signaling'. Molecular Cancer Therapeutics, 13 (5):1206-1216. [DOI]
Journal Publication
ResearchOnline@JCU
Hebbard, Lionel; Ranscht, Barbara (2014) 'Multifaceted roles of adiponectin in cancer'. Best practice & research Clinical endocrinology & metabolism, 28 (1):59-69. [DOI]
Journal Publication
ResearchOnline@JCU
Castro, David J.; Maurer, Jochen; Hebbard, Lionel; Oshima, Robert G. (2013) 'ROCK1 inhibition promotes the self-renewal of a novel mouse mammary cancer stem cell'. Stem Cell, 31 (1):12-22. [DOI]
Journal Publication
ResearchOnline@JCU
Tumoricidal effects of the JAK inhibitor Ruxolitinib (INC424) on hepatocellular carcinoma in vitro
2013
Wilson, George S.; Tian, Aiping; Hebbard, Lionel; Duan, Wei; George, Jacob; Li, Xun; Qiao, Liang (2013) 'Tumoricidal effects of the JAK inhibitor Ruxolitinib (INC424) on hepatocellular carcinoma in vitro'. Cancer letters, 341 (2):224-230. [DOI]
Journal Publication
ResearchOnline@JCU
Carulli, Lucia; Maurantonio, Mauro; Hebbard, Lionel; Baldelli, Enrica; Loria, Paola; George, Jacob (2013) 'Classical and innovative insulin sensitizing drugs for the prevention and treatment of NAFLD'. Current pharmaceutical design, 19 (29):5280-5296.
Journal Publication
ResearchOnline@JCU
van der Poorten, David; Samer, Caroline F.; Ramezani-Moghadam, Mehdi; Coulter, Sally; Kacevska, Marina; Schrijnders, Dennis; Wu, Lindsay E.; McLeod, Duncan; Bugianesi, Elisabetta; Komuta, Mina; Roskams, Tania; Liddle, Christopher; Hebbard, Lionel; George, Jacob (2013) 'Hepatic fat loss in advanced nonalcoholic steatohepatitis: are alterations in serum adiponectin the cause'. Hepatology, 57 (6):2180-2188. [DOI]
Journal Publication
ResearchOnline@JCU
Obeid, Stephanie; Hebbard, Lionel (2012) 'Role of adiponectin and its receptors in cancer'. Cancer biology & medicine, 9 (4):213-220. [DOI]
Journal Publication
ResearchOnline@JCU
Hebbard, L.; Cecena, G.; Golas, J.; Sawada, J.; Ellies, L.G.; Charbono, A.; Williams, R.; Jimenez, R.E.; Wankell, M.; Arndt, K.T.; DeJoy, S.Q.; Rollins, R.A.; Diesl, V.; Follettie, M.; Chen, L.; Rosfjord, E.; Cardiff, R.D.; Komatsu, M.; Boschelli, F.; Oshima, R.G. (2011) 'Control of mammary tumor differentiation by SKI-606 (bosutinib)'. Oncogene, 30 :301-312. [DOI]
Journal Publication
ResearchOnline@JCU
Hebbard, Lionel; George, Jacob (2011) 'Animal models of nonalcoholic fatty liver disease'. Nature reviews. Gastroenterology & hepatology, 8 :35-44. [DOI]
Journal Publication
ResearchOnline@JCU
Hebbard, Lionel W.; Maurer, Jochen; Miller, Amber; Lesperance, Jacqueline; Hassell, John; Oshima, Robert G.; Terskikh, Alexey V. (2010) 'Maternal embryonic leucine zipper kinase is upregulated and required in mammary tumor-initiating cells in vivo'. Cancer research, 70 (21):8863-8873. [DOI]
Journal Publication
ResearchOnline@JCU
van der Poorten, David; Shahidi, Mahsa; Tay, Enoch; Sesha, Jayshree; Tran, Kayla; McLeod, Duncan; Milliken, Jane S.; Ho, Vikki; Hebbard, Lionel W.; Douglas, Mark W.; George, Jacob (2010) 'Hepatitis C virus induces the cannabinoid receptor 1'. PLoS ONE, 5 (9):1-10. [DOI]
Adiponectin deficiency limits tumor vascularization in the MMTV-PyV-mT mouse model of mammary cancer
2009
Denzel, Martin S.; Hebbard, Lionel W.; Shostak, Gregory; Shapiro, Lawrence; Cardiff, Robert D.; Ranscht, Barbara (2009) 'Adiponectin deficiency limits tumor vascularization in the MMTV-PyV-mT mouse model of mammary cancer'. Clinical Cancer Research, 15 (10):3256-3264. [DOI]
Journal Publication
ResearchOnline@JCU
Hebbard, Lionel W.; Garlatti, Michèle; Young, Lawrence J.T.; Cardiff, Robert D.; Oshima, Robert G.; Ranscht, Barbara (2008) 'T-cadherin supports angiogenesis and adiponectin association with the vasculature in a mouse mammary tumor model'. Cancer research, 68 (5):1407-1416. [DOI]
Journal Publication
ResearchOnline@JCU
Oshima, Robert G.; Lesperance, Jacqueline; Munoz, Varinia; Hebbard, Lionel; Ranscht, Barbara; Sharan, Niki; Muller, William J.; Hauser, Craig A.; Cardiff, Robert D. (2004) 'Angiogenic acceleration of Neu induced mammary tumor progression and metastasis'. Cancer research, 64 :169-179. [DOI]
Journal Publication
ResearchOnline@JCU
Hebbard, Lionel; Steffen, Anja; Zawadzki, Volker; Fieber, Christina; Howells, Norma; Moll, Jürgen; Ponta, Helmut; Hofmann, Martin; Jonathan, Sleeman (2000) 'CD44 expression and regulation during mammary gland development and function'. Journal of Cell Science, 113 :2619-2630.
Journal Publication
ResearchOnline@JCU
Wyder, Lorenza; Vitaliti, Alessandra; Schneider, Henriette; Hebbard, Lionel W.; Moritz, Dirk R.; Wittmer, Mariana; Ajmo, Malek; Klemenz, Roman (2000) 'Increased expression of H/T-cadherin in tumor-penetrating blood vessels'. Cancer research, 60 :4682-4688.
Journal Publication
ResearchOnline@JCU
Adiponectin induces pro-infl ammatory cytokines in kupffer cells via the activation of mapk pathways
2010
Smith, B.W.; Hebbard, L.; George, J. (2010) 'Adiponectin induces pro-infl ammatory cytokines in kupffer cells via the activation of mapk pathways' Journal of Gastroenterology and Hepatology, 25 (s3) :A6-A6.
Journal Contribution
ResearchOnline@JCU
Walker, Sarah L.; George, Jacob; Hebbard, Lionel W. (2012) 'Animal models of hepatocellular carcinoma' In: Walker, Sarah L., George, Jacob, and Hebbard, Lionel W. (2012) Animal models of hepatocellular carcinoma. In: Qiao, Liang, Li, Yumin, Yan, Xiang, and George, Jacob, (eds.) Molecular Aspects of Hepatocellular Carcinoma. Bentham Books, Ipswich, QLD, Australia, pp. 116-128(Eds.). Molecular Aspects of Hepatocellular Carcinoma. Ipswich, QLD, Australia : Bentham Books. [DOI]
Book Chapter
ResearchOnline@JCU
Hebbard, Lionel W. (2012) 'Role of angiogenesis in HCC development and therapy' In: Hebbard, Lionel W. (2012) Role of angiogenesis in HCC development and therapy. In: Qiao, Liang, Li, Yumin, Yan, Xiang, and George, Jacob, (eds.) Molecular Aspects of Hepatocellular Carcinoma. Bentham Books, Ipswich, QLD, Australia, pp. 149-161(Eds.). Molecular Aspects of Hepatocellular Carcinoma. Ipswich, QLD, Australia : Bentham Books. [DOI]
Book Chapter
ResearchOnline@JCU