The role of adiponectin in NAFLD progression

Esmaili, S.;George, J.;Hebbard, L.

Abstract

Lipid toxicity and inflammation are important components in the transition of non-alcoholic fatty liver disease (NAFLD) to non-alcoholic steatohepatitis (NASH). Factors such as reduced adiponectin have been associated with liver steatosis and inflammation. However, the molecular events underlying NAFLD progression in respect of adiponectin have not been thoroughly investigated. Recent data suggests that free cholesterol sensitizes hepatocytes to TNF-alpha and Fas-induced apoptosis and steatohepatitis development. In this study we examined the association of adiponectin and cholesterol to NAFLD progression.

Journal

Journal of Gastroenterology and Hepatology

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Journal of Gastroenterology and Hepatology

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1440-1746

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Wiley-Blackwell

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