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Haleagrahara Nagaraja

Projects

6

Publications

49

Awards

8


Contact Details

Head, Foundation Studies
    Associate Professor

    Biography

    Nagaraja Haleagrahara, PhD, Grad CertEd (Academic Practice), is an Associate Professor and Head of Foundation Studies at the College of Medicine & Dentistry. With a master’s in medical physiology, his PhD explored the “Pathophysiological Changes in the Neuroendocrine System during Stress” at Manipal University, a leading university in collaborative biomedical research. His research focuses on the molecular mechanisms of human diseases, including rheumatoid arthritis, neurodegenerative diseases, and diabetes. His continuing research has enabled further discoveries in disease pathophysiology and novel therapeutics, resulting in over 100 publications in international peer-reviewed journals, over 3200 citations, an h-index of 32 and an i10 index of 57.

    Nagaraja has extensive experience teaching physiology and pathophysiology in the tertiary setting. He lectured in an undergraduate medical programme at Manipal University in 1989 and has taught across a range of undergraduate, postgraduate, and content areas. Moving to IMU University, Malaysia, in 2004, he held positions as a Senior Lecturer and Associate Professor.

    As an extensively experienced and internationally recognised physiology educator, Nagaraja is a staunch advocate for quality medical education. His dedication to fostering student learning and engagement is truly inspiring. In 2023, he was honoured with the Australian Medical Students Association (AMSA) National Teaching Award for his outstanding contribution to medical education. This recognition underscores his enduring commitment to student learning. His excellence in teaching has also been acknowledged with multiple Dean’s Teaching Excellence Awards, including in 2017, 2018, 2020, and 2022, further solidifying his reputation as a leading educator in his field. He has played a key role in developing innovative curricula that promote active learning, incorporating blended learning techniques and case-based teaching to engage students in complex medical concepts.  Nagaraja has been consistently active in education research since 2005, with a keen interest in medical education, focusing on problem-based learning, blended learning, and learning technologies.

    His diverse research interests include oxidative stress, antioxidants, rheumatoid arthritis, diabetes foot ulcer, and neurodegeneration. One of his key research projects, funded by Arthritis Australia, explored the potential of flavonoids as an anti-inflammatory therapy for rheumatoid arthritis, identifying the therapeutic properties of quercetin. His research team at IMU University also showed the neuroprotective and therapeutic effects of tocotrienol fraction against neuronal degeneration in Parkinson’s disease. This work has garnered international attention and collaboration.

    As an educator, Nagaraja Haleagrahara has successfully supervised numerous Honours, Master’s, and PhD students, many of whom have gone on to contribute to cutting-edge research in their fields. His passion for supporting students' full engagement in their education is profound, focusing on cultivating a lifelong commitment to learning rather than merely achieving high grades. His leadership as Head of Foundation Studies at the College of Medicine & Dentistry reflects his dedication to academic excellence and student success.

     Nagaraja Haleagrahara’s work extends beyond Australia, with active collaborations with institutions such as the Manipal University, IMU University in Malaysia, Monash University Malaysia, and the Malaysian Palm Oil Board. These international research partnerships have produced impactful results, particularly in rheumatoid arthritis and neurodegenerative disease therapies. His interdisciplinary and globally-minded approach to research is impressive. He continues to advance medical science and education, solidifying his reputation as a leader in the field of physiology.

    Proven Expert Capabilities:

    Excellence in Tertiary Teaching – leadership; high performance on student evaluation/performance; national recognition for teaching excellence.

    Best Practice Medical Education – research and presentations since 2004.

    Collaborative Educational Leader - strong cross-disciplinary partnerships within and outside the university

    Strategic and Relevant Curriculum Development and Reform – innovation in new learning modules; peer collaboration; increased blended learning; improved learning outcomes and student satisfaction.

    Successful Academic Researcher and Publisher – high quality and high volume in research publications; internationally cited; contribution to public wellbeing.

    Intellectual Leadership in Researchadvanced international knowledge on (i) the cause and molecular mechanisms of neurodegeneration in Parkinson’s disease and (ii) how flavonoids will help protect against nerve degeneration. (iii) novel proteins from hookworm as antiinflammatory therapeutics in rheumatoid arthritis

    Mentorship Advocate - actively mentor academic staff and students - fostering an inclusive environment. 

    Procurement and Management of Research and Teaching Grants – internal and external.

    Strategic and Resource Leadership – establishing the JCU Rheumatoid Arthritis (RA) Research Program through applying for competitive grants.

    Professional and Highly Collaborative Approach to Teaching, Learning, Research and Service, establishing both internal and external partnerships – local and international.

    Effective Student Supervision – all honours students published, ongoing supervision of Honours, Masters, PhD students.

    Leadership Committee and Membership Roles – service and engagement.Leadership Committee and Membership Roles – service and engagement.

    Expert Reviewer and Assessor – member of editorial boards; expert assessor of grant applications; invited peer reviewer for publications; reviewer for scientific journals.

    Research

    Research Interests

    Immunotherapy for Rheumatoid Arthritis

    Neuroprotective effects of palm phytonutrients in Parkinson’s disease (Primary Advisor -International Medical University, Kuala Lumpur, Malaysia)

    Neuroprotective effects of Vitamin E on oxidative stress-induced dopaminergic neuronal dysfunction in Parkinson’s disease (Secondary Advisor -International Medical University, Kuala Lumpur, Malaysia)

    Biomarkers of diabetic foot ulcer

    Rheumatoid arthritis; Bioflavonoids and collagen-induced arthritis; Anti-rheumatoid arthritic activity of flavonoids; Anti-rheumatoid arthritic activity of hookworm proteins; Diabetes; Diabetic foot ulcer; Growth factors in diabetic foot ulcer

    Bioflavonoids and inflammatory pathways in Rheumatoid Arthritis

    Projects
    Research Collaborators and Partners
    Australian Institute of Tropical Health and Medicine
    Townsville University Hospital
    Monash University
    Diabetes Australia
    Arthritis Australia

    Teaching

    Teaching Interests

    Physiology, Pathophysiology, Endocrinology, Neurophysiology, Hematology and Renal Physiology

    Learning styles and approaches of undergraduate medical students

    Evaluating the impact of an integrated blended e-learning program on learning delivery and enhancement in medical education

    Evaluating the impact of mobile integrated learning resources on medical student learning outcomes


    Research Advisor Accreditation
    Advisor Type

    Primary


    Taught Modules
    Completed JCU Research Students
    The Role of the Transforming Growth Factor Beta (TGF-ß) Family in Diabetic Foot Ulcer (DFU) Recovery
    Master of Philosophy (Medical and Molecular Sciences)- 2023
    Current Honours and External Research Students
    Persistent post-operative opioid use after cardiac surgery in regional/rural/remote areas
    HONOURS- 2024
    Establishment of Pelvic Inflammatory Disease mouse model and the Effects of novel anti-inflammatory proteins
    HONOURS- 2024
    Anti-inflammatory response of venom proteins on collage induced arthritis murine model
    HONOURS- 2023
    Completed Honours and External Research Students
    Antiinflmmatory actions of rutin exhibit additive effects when applied as a combination therapy with nobiletin and methotrexate, in a murine model of collagen induced arthritis
    HONOURS
    Molecular Mechanism of Antioxidant Effects of Quercetin Glycoside Derivatives Against 6-Hydroxydopamine (6-OHDA) Induced Cytotoxic Damage in PC-12 Neuronal Cells
    RESEARCH_MASTERS
    Antiinflmmatory effects of standardised ethanolic extract from the rind of the Nephelium Lappceum fruit in a rat model of rheumatoid arthritis
    RESEARCH_MASTERS
    Cardioprotective role of oxytocin in pressure overload-induced cardiac hypertrophy and heart failure
    HONOURS
    Novel inflammatory markers for the diagnosis of diabetic foot osteomyelitis at the Townsville University Hospital – a pilot study.
    HONOURS
    Dose reduction of ocrelizumab in multiple sclerosis:observational study
    HONOURS
    Therapeutic effects of nobilitin in an animal model of rheumatoid arthritis
    HONOURS
    The effect of ostrich oil in a rat model of arthritis
    PHD
    Hypoxia Inducible Factor 1 alpha (HIF-1α) in Type 2 Diabetes Mellitus
    RESEARCH_MASTERS
    Induction of intracellular death of breast cancer cells through combined intracellular delivery of a tumor suppressor gene and small interfering RNAS against growth factor receptor and anti-apoptotic genes
    PHD
    Adjunct antiinflmmatory therapy for rheumatoid arthritis
    HONOURS
    Adipose Tissue and Fibrofatty Deposits in Chest Wall Muscle and the Hearts of Diabetic and Nondiabetic Patients Across a Wide Range of BMI Values
    HONOURS
    neuroprotective Mechanisms of oral supplementation of alpha or gamma tocotrienol in arta model of Parkinsons disease
    PHD
    Neuroprotective role of tocotrienols against 6-hydroxydopamine (6-OHDA) induced cytotoxic damage in SH-SY5Y neuroblastoma cells
    PHD
    Teaching Grants

    Activities

    Employment
    Education
    Associations
    Awards
    Committees

    Output

    Langdon, Kane; Buitrago, Geraldine; Pickering, Darren; Giacomin, Paul; Loukas, Alex; Haleagrahara, N...
    Journal Publication ResearchOnline@JCU
    Magalingam, Kasthuri Bai; Somanath, Sushela Devi; Nagaraja, Haleagrahara; Selvaduray, Kanga Rani; Ra...
    Journal Publication ResearchOnline@JCU
    Kumari, Mangala; Ramdas, Premdass; Radhakrishnan, Ammu Kutty; Kutty, Methil Kannan; Haleagrahara, Na...
    Journal Publication ResearchOnline@JCU
    Magalingam, Kasthuri Bai; Radhakrishnan, Ammu Kutty; Somanath, Sushela Devi; Md, Shadab; Haleagrahar...
    Journal Publication ResearchOnline@JCU
    Langdon, Kane; Phie, James; Thapa, Chetan B.; Biros, Erik; Loukas, Alex; Haleagrahara, Nagaraja (201...
    Journal Publication ResearchOnline@JCU
    Venkatesh, Shashidhar; Rao, Yeshwanth K.; Nagaraja, Haleagrahara; Woolley, Torres; Alele, Faith O.; ...
    Journal Publication ResearchOnline@JCU
    Magalingam, Kasthuri Bai; Radhakrishnan, Ammu; Ping, Ng Shee; Haleagrahara, Nagaraja (2018) 'Current. BioMe, 201...
    Journal Publication ResearchOnline@JCU
    Le Rossignol, Scott; Ketheesan, Natkunam; Nagaraja, Haleagrahara (2018) 'Redox-sensitive transcripti. International Reviews of , 37 (3):129-143. [DOI] ...
    Journal Publication ResearchOnline@JCU
    Langdon, Kane; Nagaraja, Haleagrahara (2018) 'Regulatory T-cell dynamics with abatacept treatment in. International Reviews of Immunology, 37 (4):206-214. [DOI] ...
    Journal Publication ResearchOnline@JCU
    Nagaraja, Haleagrahara; Hodgson, Kelly; Miranda-Hernandez, Socorro; Hughes, Samuel; Bangra Kulur, An...
    Journal Publication ResearchOnline@JCU
    Haleagrahara, Nagaraja; Miranda-Hernandez, Socorro; Alim, Md Abdul; Hayes, Linda; Bird, Guy; Kethees...
    Journal Publication ResearchOnline@JCU
    Hughes, Samuel D.; Ketheesan, Natkunam; Haleagrahara, Nagaraja (2017) 'The therapeutic potential of . Critical Reviews in Food Sc, 57 (17):3601-3613. [DOI] ...
    Journal Publication ResearchOnline@JCU
    Magalingam, Kasthuri Bai; Radhakrishnan, Ammu; Haleagrahara, Nagaraja (2016) 'Protective effects of . International Journa, 29 (1):30-39. [DO ...
    Journal Publication ResearchOnline@JCU
    Subramania, Shonia; Radhakrishnan, Ammu; Chakravarthi, Srikumar; Palanisamy, Umi Devi; Haleagrahara,...
    Journal Publication ResearchOnline@JCU
    Palanisamy, Uma D.; Sivanathan, Muniswaran; Subramaniam, Thavamanithevi; Radhakrishnan, Ammu K.; Nag...
    Journal Publication ResearchOnline@JCU
    Phie, James; Haleagrahara, Nagaraja; Newton, Patricia; Constantinoiu, Constantin; Sarnyai, Zoltan; C...
    Journal Publication ResearchOnline@JCU
    Magalingam, Kasthuri Bai; Radhakrishnan, Ammu; Ramdas, Premdass; Nagaraja, Haleagrahara (2015) 'Quer. Jo, ...
    Journal Publication ResearchOnline@JCU
    Magalingam, Kasthuri Bai; Radhakrishnan, Ammu Kutty; Haleagrahara, Nagaraja (2015) 'Protective mecha. 5 :1-14. [DOI ...
    Journal Publication ResearchOnline@JCU
    Akhilesh, Meenakshi; Mahalingam, Vivekananda; Nalliah, Sivalingam; Ali, Rosalina Mohd; Ganesalingam,...
    Journal Publication ResearchOnline@JCU
    Haleagrahara, Nagaraja; Swaminathan, Mirashini; Chakravarthi, Srikumar; Radhakrishnan, Ammu (2014) '....
    Journal Publication ResearchOnline@JCU
    Radhakrishnan, Ammu; Tudawe, Dulanthi; Chakravarthi, Srikumar; Chiew, Gan Seng; Nagaraja, Haleagraha...
    Journal Publication ResearchOnline@JCU
    Somasundaram, Shanmugam ; Chakravarthi, Srikumar; Radhakrishnan, Ammu; Ramdas, Premdass; Nagaraja, H...
    Journal Publication ResearchOnline@JCU
    Stepanyan, Vahan; Crowe, Melissa; Nagaraja, Haleagrahara; Bowden, Bruce (2014) 'Effects of vitamin E. Applied Physiology, 39 (9):1029-1037...
    Journal Publication ResearchOnline@JCU
    Magalingam, Kasthuri Bai; Radhakrishnan, Ammu; Haleagrahara, Nagaraja (2014) 'Protective effects of . BMC Research Notes, 7 . [DOI] ...
    Journal Publication ResearchOnline@JCU
    Haleagrahara, Nagaraja; Chakravarthi, Srikumar; Bangra Kulur, Anupama; Yee, Tan Mun (2014) 'Plant fl. 4 (4):...
    Journal Publication ResearchOnline@JCU
    Haleagrahara, Nagaraja; Siew, Cheng Jun; Ponnusamy, Kumar (2013) 'Effect of quercetin and desferriox. 38 (1):25-33. [DOI] ...
    Journal Publication ResearchOnline@JCU
    Tan, Jian Ren; Chakravarthi, Srikumar; Judson, John Paul; Haleagrahara, Nagaraja; Segarra, Ignacio (...
    Journal Publication ResearchOnline@JCU
    Magalingam, Kasthuri Bai; Radhakrishnan, Ammu; Haleagrahara, Nagaraja (2013) 'Rutin, a bioflavonoid . 32 (1):235-240. [DO ...
    Journal Publication ResearchOnline@JCU
    Haleagrahara, Nagaraja; Tudawe, Dulanthi; Chakravarthi, Srikumar; Kutty Radhakrishnan, Ammu (2013) '....
    Journal Publication ResearchOnline@JCU
    Akhilesh, Meenakshi ; Mahalingam, Vivekananda ; Nalliah, Sivalingam; Ali, Rosalina Mohd; Murali, Gan...
    Journal Publication ResearchOnline@JCU
    Tham, Ching S.; Chakravarthi, Spikumar; Haleagrahara, Nagaraja; Alwis, Ranjit de (2013) 'Morphologic. EXPERIMEN, 5 (2):6...
    Journal Publication ResearchOnline@JCU
    Haw, Khor Yen; Chakravarthi, Srikumar; Haleagrahara, Nagaraja; Rao, Mallikarjuna (2012) 'Effects of . EXPERIMEN, 3 (1):9...
    Journal Publication ResearchOnline@JCU
    Appukutty, Mahenderan; Radhakrishnan, Ammu Kutty; Ramasamy, Kalavathy; Ramasamy, Rajesh; Abdul Majee...
    Journal Publication ResearchOnline@JCU
    Kumar, Shashi; Chakravarthi, Srikumar; Gan Seng, Chiew; Subramaniam, Thavamanithevi; Palanisamy, Uma...
    Journal Publication ResearchOnline@JCU
    Matthews, Lisa; Haleagrahara, Nagaraja; Chakravarthi, Srikumar (2011) 'Insulin-Like Growth Factor-1 . 3 :1-7. [DOI] ...
    Journal Publication ResearchOnline@JCU
    Haleagrahara, Nagaraja; Chakravarthi, Srikumar; Mathews, Lisa (2011) 'Insulin like growth factor-1 (. International Journal of Mol, 12 (12):8562-8574. [DOI] ...
    Journal Publication ResearchOnline@JCU
    Palanisamy, Uma Devi; Sivanathan, Muniswaran; Radhakrishnan, Ammu Kutty; Haleagrahara, Nagajara; Sub...
    Journal Publication ResearchOnline@JCU
    Jackie, Tan; Haleagrahara, Nagaraja; Chakravarthi, Srikumar (2011) 'Antioxidant effects of Etlingera. BMC Research Notes, 4 :1-8. [DOI] ...
    Journal Publication ResearchOnline@JCU
    Perera, Joachim; Tan, Joon Heng; Jeevathayaparan, S.; Chakravarthi, Srikumar; Haleagrahara, Nagaraja...
    Journal Publication ResearchOnline@JCU
    Haleagrahara, Nagaraja; Siew, Cheng Jun; Mitra, Nilesh Kumar; Kumari, Mangala (2011) 'Neuroprotectiv. Neuroscience, 500 (2):13...
    Journal Publication ResearchOnline@JCU
    Tudave, Dulanthi; Radhakrishnan, Ammu; Chakravarthi, Srikumar; Haleagrahara, Nagaraja (2011) 'Modula. 60 (...
    Journal Publication ResearchOnline@JCU
    Haleagrahara, Nagaraja; Varkkey, Julian; Chakravarthi, Srikumar (2011) 'Cardioprotective effects of . International Journal of M, 12 (10):7100-7113. [DOI ...
    Journal Publication ResearchOnline@JCU
    Haleagrahara, Nagaraja; Varkkey, Julian; Chakravarthi, Srikumar (2011) 'N-acetylcysteine offers card. 11 (4):373-381. [DOI] ...
    Journal Publication ResearchOnline@JCU
    Haleagrahara, Nagaraja; Jackie, Tan; Chakravarthi, Srikumar; Rao, Mallikarjuna; Pasupathi, Thanikach...
    Journal Publication ResearchOnline@JCU
    Haleagrahara, Nagaraja; Ponnusamy, Kumar (2010) 'Neuroprotective effect of Centella asiatica extract. 35 (1):41-47. [DOI] ...
    Journal Publication ResearchOnline@JCU
    Haleagrahara, Nagaraja; Radhakrishnan, Ammu; Lee, Nagarajah; Kumar, Pomnnusamy (2009) 'Flavonoid que. European Jo, 621 (1-3)...
    Journal Publication ResearchOnline@JCU
    Carlisle, Karen; Johnson, Peter; Mudd, Julie; Nagaraja, Haleagrahara; Moodley, Nishila (2023) ANZAHP...
    Conference Contribution ResearchOnline@JCU