photo

Haleagrahara Nagaraja

Projects

6

Publications

49

Awards

8


Contact Details

Biography

Nagaraja Haleagrahara, PhD, Grad CertEd (Academic Practice), is an Associate Professor and Head of Foundation Studies at the College of Medicine & Dentistry. With a master’s in medical physiology, his PhD explored the “Pathophysiological Changes in the Neuroendocrine System during Stress” at Manipal University, a leading university in collaborative biomedical research. His research focuses on the molecular mechanisms of human diseases, including rheumatoid arthritis, neurodegenerative diseases, and diabetes. His continuing research has enabled further discoveries in disease pathophysiology and novel therapeutics, resulting in over 100 publications in international peer-reviewed journals, over 3200 citations, an h-index of 32 and an i10 index of 57.

Nagaraja has extensive experience teaching physiology and pathophysiology in the tertiary setting. He lectured in an undergraduate medical programme at Manipal University in 1989 and has taught across a range of undergraduate, postgraduate, and content areas. Moving to IMU University, Malaysia, in 2004, he held positions as a Senior Lecturer and Associate Professor.

As an extensively experienced and internationally recognised physiology educator, Nagaraja is a staunch advocate for quality medical education. His dedication to fostering student learning and engagement is truly inspiring. In 2023, he was honoured with the Australian Medical Students Association (AMSA) National Teaching Award for his outstanding contribution to medical education. This recognition underscores his enduring commitment to student learning. His excellence in teaching has also been acknowledged with multiple Dean’s Teaching Excellence Awards, including in 2017, 2018, 2020, and 2022, further solidifying his reputation as a leading educator in his field. He has played a key role in developing innovative curricula that promote active learning, incorporating blended learning techniques and case-based teaching to engage students in complex medical concepts.  Nagaraja has been consistently active in education research since 2005, with a keen interest in medical education, focusing on problem-based learning, blended learning, and learning technologies.

His diverse research interests include oxidative stress, antioxidants, rheumatoid arthritis, diabetes foot ulcer, and neurodegeneration. One of his key research projects, funded by Arthritis Australia, explored the potential of flavonoids as an anti-inflammatory therapy for rheumatoid arthritis, identifying the therapeutic properties of quercetin. His research team at IMU University also showed the neuroprotective and therapeutic effects of tocotrienol fraction against neuronal degeneration in Parkinson’s disease. This work has garnered international attention and collaboration.

As an educator, Nagaraja Haleagrahara has successfully supervised numerous Honours, Master’s, and PhD students, many of whom have gone on to contribute to cutting-edge research in their fields. His passion for supporting students' full engagement in their education is profound, focusing on cultivating a lifelong commitment to learning rather than merely achieving high grades. His leadership as Head of Foundation Studies at the College of Medicine & Dentistry reflects his dedication to academic excellence and student success.

 Nagaraja Haleagrahara’s work extends beyond Australia, with active collaborations with institutions such as the Manipal University, IMU University in Malaysia, Monash University Malaysia, and the Malaysian Palm Oil Board. These international research partnerships have produced impactful results, particularly in rheumatoid arthritis and neurodegenerative disease therapies. His interdisciplinary and globally-minded approach to research is impressive. He continues to advance medical science and education, solidifying his reputation as a leader in the field of physiology.

Proven Expert Capabilities:

Excellence in Tertiary Teaching – leadership; high performance on student evaluation/performance; national recognition for teaching excellence.

Best Practice Medical Education – research and presentations since 2004.

Collaborative Educational Leader - strong cross-disciplinary partnerships within and outside the university

Strategic and Relevant Curriculum Development and Reform – innovation in new learning modules; peer collaboration; increased blended learning; improved learning outcomes and student satisfaction.

Successful Academic Researcher and Publisher – high quality and high volume in research publications; internationally cited; contribution to public wellbeing.

Intellectual Leadership in Researchadvanced international knowledge on (i) the cause and molecular mechanisms of neurodegeneration in Parkinson’s disease and (ii) how flavonoids will help protect against nerve degeneration. (iii) novel proteins from hookworm as antiinflammatory therapeutics in rheumatoid arthritis

Mentorship Advocate - actively mentor academic staff and students - fostering an inclusive environment. 

Procurement and Management of Research and Teaching Grants – internal and external.

Strategic and Resource Leadership – establishing the JCU Rheumatoid Arthritis (RA) Research Program through applying for competitive grants.

Professional and Highly Collaborative Approach to Teaching, Learning, Research and Service, establishing both internal and external partnerships – local and international.

Effective Student Supervision – all honours students published, ongoing supervision of Honours, Masters, PhD students.

Leadership Committee and Membership Roles – service and engagement.Leadership Committee and Membership Roles – service and engagement.

Expert Reviewer and Assessor – member of editorial boards; expert assessor of grant applications; invited peer reviewer for publications; reviewer for scientific journals.

Research

Research Interests

Immunotherapy for Rheumatoid Arthritis

Neuroprotective effects of palm phytonutrients in Parkinson’s disease (Primary Advisor -International Medical University, Kuala Lumpur, Malaysia)

Neuroprotective effects of Vitamin E on oxidative stress-induced dopaminergic neuronal dysfunction in Parkinson’s disease (Secondary Advisor -International Medical University, Kuala Lumpur, Malaysia)

Biomarkers of diabetic foot ulcer

Rheumatoid arthritis; Bioflavonoids and collagen-induced arthritis; Anti-rheumatoid arthritic activity of flavonoids; Anti-rheumatoid arthritic activity of hookworm proteins; Diabetes; Diabetic foot ulcer; Growth factors in diabetic foot ulcer

Bioflavonoids and inflammatory pathways in Rheumatoid Arthritis

Projects
Research Collaborators and Partners
Arthritis Australia
Australian Institute of Tropical Health and Medicine
Townsville University Hospital
Monash University
Diabetes Australia

Teaching

Teaching Interests

Physiology, Pathophysiology, Endocrinology, Neurophysiology, Hematology and Renal Physiology

Learning styles and approaches of undergraduate medical students

Evaluating the impact of an integrated blended e-learning program on learning delivery and enhancement in medical education

Evaluating the impact of mobile integrated learning resources on medical student learning outcomes


Research Advisor Accreditation
Advisor Type

Primary


Taught Modules
Completed JCU Research Students
The Role of the Transforming Growth Factor Beta (TGF-ß) Family in Diabetic Foot Ulcer (DFU) Recovery
Master of Philosophy (Medical and Molecular Sciences)- 2023
Current Honours and External Research Students
Persistent post-operative opioid use after cardiac surgery in regional/rural/remote areas
HONOURS- 2024
Establishment of Pelvic Inflammatory Disease mouse model and the Effects of novel anti-inflammatory proteins
HONOURS- 2024
Anti-inflammatory response of venom proteins on collage induced arthritis murine model
HONOURS- 2023
Completed Honours and External Research Students
Adipose Tissue and Fibrofatty Deposits in Chest Wall Muscle and the Hearts of Diabetic and Nondiabetic Patients Across a Wide Range of BMI Values
HONOURS
Antiinflmmatory effects of standardised ethanolic extract from the rind of the Nephelium Lappceum fruit in a rat model of rheumatoid arthritis
RESEARCH_MASTERS
Novel inflammatory markers for the diagnosis of diabetic foot osteomyelitis at the Townsville University Hospital – a pilot study.
HONOURS
Therapeutic effects of nobilitin in an animal model of rheumatoid arthritis
HONOURS
Molecular Mechanism of Antioxidant Effects of Quercetin Glycoside Derivatives Against 6-Hydroxydopamine (6-OHDA) Induced Cytotoxic Damage in PC-12 Neuronal Cells
RESEARCH_MASTERS
Adjunct antiinflmmatory therapy for rheumatoid arthritis
HONOURS
Dose reduction of ocrelizumab in multiple sclerosis:observational study
HONOURS
neuroprotective Mechanisms of oral supplementation of alpha or gamma tocotrienol in arta model of Parkinsons disease
PHD
Neuroprotective role of tocotrienols against 6-hydroxydopamine (6-OHDA) induced cytotoxic damage in SH-SY5Y neuroblastoma cells
PHD
Cardioprotective role of oxytocin in pressure overload-induced cardiac hypertrophy and heart failure
HONOURS
Hypoxia Inducible Factor 1 alpha (HIF-1α) in Type 2 Diabetes Mellitus
RESEARCH_MASTERS
Antiinflmmatory actions of rutin exhibit additive effects when applied as a combination therapy with nobiletin and methotrexate, in a murine model of collagen induced arthritis
HONOURS
The effect of ostrich oil in a rat model of arthritis
PHD
Induction of intracellular death of breast cancer cells through combined intracellular delivery of a tumor suppressor gene and small interfering RNAS against growth factor receptor and anti-apoptotic genes
PHD
Teaching Grants

Activities

Employment
Education
Associations
Awards
Committees

Output

Langdon, Kane; Buitrago, Geraldine; Pickering, Darren; Giacomin, Paul; Loukas, Alex; Haleagrahara, N...
Journal Publication Open Access ResearchOnline@JCU
Magalingam, Kasthuri; Somanath, Sushela Devi; Ramdas, Premdass; Nagaraja, Haleagrahara; Radhakrishna...
Journal Publication Open Access ResearchOnline@JCU
Magalingam, Kasthuri Bai; Somanath, Sushela Devi; Nagaraja, Haleagrahara; Selvaduray, Kanga Rani; Ra...
Journal Publication Open Access ResearchOnline@JCU
Magalingam, Kasthuri Bai; Somanath, Sushela Devi; Md, Shadab; Nagaraja, Haleagrahara; Fu, Ju-Yen; Se...
Journal Publication Open Access ResearchOnline@JCU
Kumari, Mangala; Ramdas, Premdass; Radhakrishnan, Ammu Kutty; Kutty, Methil Kannan; Haleagrahara, Na...
Journal Publication Open Access ResearchOnline@JCU
Magalingam, Kasthuri Bai; Radhakrishnan, Ammu Kutty; Somanath, Sushela Devi; Md, Shadab; Haleagrahar...
Journal Publication Open Access ResearchOnline@JCU
Langdon, Kane; Phie, James; Thapa, Chetan B.; Biros, Erik; Loukas, Alex; Haleagrahara, Nagaraja (201...
Journal Publication Open Access ResearchOnline@JCU
Venkatesh, Shashidhar; Rao, Yeshwanth K.; Nagaraja, Haleagrahara; Woolley, Torres; Alele, Faith O.; ...
Journal Publication Open Access ResearchOnline@JCU
Le Rossignol, Scott; Ketheesan, Natkunam; Nagaraja, Haleagrahara (2018) 'Redox-sensitive transcripti. International Reviews of , 37 (3):129-143. [DOI] ...
Journal Publication Open Access ResearchOnline@JCU
Magalingam, Kasthuri Bai; Radhakrishnan, Ammu; Ping, Ng Shee; Haleagrahara, Nagaraja (2018) 'Current. BioMe, 201...
Journal Publication Open Access ResearchOnline@JCU
Langdon, Kane; Nagaraja, Haleagrahara (2018) 'Regulatory T-cell dynamics with abatacept treatment in. International Reviews of Immunology, 37 (4):206-214. [DOI] ...
Journal Publication Open Access ResearchOnline@JCU
Nagaraja, Haleagrahara; Hodgson, Kelly; Miranda-Hernandez, Socorro; Hughes, Samuel; Bangra Kulur, An...
Journal Publication Open Access ResearchOnline@JCU
Hughes, Samuel D.; Ketheesan, Natkunam; Haleagrahara, Nagaraja (2017) 'The therapeutic potential of . Critical Reviews in Food Sc, 57 (17):3601-3613. [DOI] ...
Journal Publication Open Access ResearchOnline@JCU
Haleagrahara, Nagaraja; Miranda-Hernandez, Socorro; Alim, Md Abdul; Hayes, Linda; Bird, Guy; Kethees...
Journal Publication Open Access ResearchOnline@JCU
Magalingam, Kasthuri Bai; Radhakrishnan, Ammu; Haleagrahara, Nagaraja (2016) 'Protective effects of . International Journa, 29 (1):30-39. [DO ...
Journal Publication Open Access ResearchOnline@JCU
Phie, James; Haleagrahara, Nagaraja; Newton, Patricia; Constantinoiu, Constantin; Sarnyai, Zoltan; C...
Journal Publication Open Access ResearchOnline@JCU
Magalingam, Kasthuri Bai; Radhakrishnan, Ammu Kutty; Haleagrahara, Nagaraja (2015) 'Protective mecha. 5 :1-14. [DOI ...
Journal Publication Open Access ResearchOnline@JCU
Subramania, Shonia; Radhakrishnan, Ammu; Chakravarthi, Srikumar; Palanisamy, Umi Devi; Haleagrahara,...
Journal Publication Open Access ResearchOnline@JCU
Palanisamy, Uma D.; Sivanathan, Muniswaran; Subramaniam, Thavamanithevi; Radhakrishnan, Ammu K.; Nag...
Journal Publication Open Access ResearchOnline@JCU
Magalingam, Kasthuri Bai; Radhakrishnan, Ammu; Ramdas, Premdass; Nagaraja, Haleagrahara (2015) 'Quer. Jo, ...
Journal Publication Open Access ResearchOnline@JCU
Akhilesh, Meenakshi; Mahalingam, Vivekananda; Nalliah, Sivalingam; Ali, Rosalina Mohd; Ganesalingam,...
Journal Publication Open Access ResearchOnline@JCU
Haleagrahara, Nagaraja; Swaminathan, Mirashini; Chakravarthi, Srikumar; Radhakrishnan, Ammu (2014) '....
Journal Publication Open Access ResearchOnline@JCU
Radhakrishnan, Ammu; Tudawe, Dulanthi; Chakravarthi, Srikumar; Chiew, Gan Seng; Nagaraja, Haleagraha...
Journal Publication Open Access ResearchOnline@JCU
Somasundaram, Shanmugam ; Chakravarthi, Srikumar; Radhakrishnan, Ammu; Ramdas, Premdass; Nagaraja, H...
Journal Publication Open Access ResearchOnline@JCU
Stepanyan, Vahan; Crowe, Melissa; Nagaraja, Haleagrahara; Bowden, Bruce (2014) 'Effects of vitamin E. Applied Physiology, 39 (9):1029-1037...
Journal Publication Open Access ResearchOnline@JCU
Magalingam, Kasthuri Bai; Radhakrishnan, Ammu; Haleagrahara, Nagaraja (2014) 'Protective effects of . BMC Research Notes, 7 . [DOI] ...
Journal Publication Open Access ResearchOnline@JCU
Haleagrahara, Nagaraja; Chakravarthi, Srikumar; Bangra Kulur, Anupama; Yee, Tan Mun (2014) 'Plant fl. 4 (4):...
Journal Publication Open Access ResearchOnline@JCU
Magalingam, Kasthuri Bai; Radhakrishnan, Ammu; Haleagrahara, Nagaraja (2013) 'Rutin, a bioflavonoid . 32 (1):235-240. [DO ...
Journal Publication Open Access ResearchOnline@JCU
Haleagrahara, Nagaraja; Tudawe, Dulanthi; Chakravarthi, Srikumar; Kutty Radhakrishnan, Ammu (2013) '....
Journal Publication Open Access ResearchOnline@JCU
Akhilesh, Meenakshi ; Mahalingam, Vivekananda ; Nalliah, Sivalingam; Ali, Rosalina Mohd; Murali, Gan...
Journal Publication Open Access ResearchOnline@JCU
Tham, Ching S.; Chakravarthi, Spikumar; Haleagrahara, Nagaraja; Alwis, Ranjit de (2013) 'Morphologic. EXPERIMEN, 5 (2):6...
Journal Publication Open Access ResearchOnline@JCU
Haleagrahara, Nagaraja; Siew, Cheng Jun; Ponnusamy, Kumar (2013) 'Effect of quercetin and desferriox. 38 (1):25-33. [DOI] ...
Journal Publication Open Access ResearchOnline@JCU
Tan, Jian Ren; Chakravarthi, Srikumar; Judson, John Paul; Haleagrahara, Nagaraja; Segarra, Ignacio (...
Journal Publication Open Access ResearchOnline@JCU
Appukutty, Mahenderan; Radhakrishnan, Ammu Kutty; Ramasamy, Kalavathy; Ramasamy, Rajesh; Abdul Majee...
Journal Publication Open Access ResearchOnline@JCU
Kumar, Shashi; Chakravarthi, Srikumar; Gan Seng, Chiew; Subramaniam, Thavamanithevi; Palanisamy, Uma...
Journal Publication Open Access ResearchOnline@JCU
Haw, Khor Yen; Chakravarthi, Srikumar; Haleagrahara, Nagaraja; Rao, Mallikarjuna (2012) 'Effects of . EXPERIMEN, 3 (1):9...
Journal Publication Open Access ResearchOnline@JCU
Matthews, Lisa; Haleagrahara, Nagaraja; Chakravarthi, Srikumar (2011) 'Insulin-Like Growth Factor-1 . 3 :1-7. [DOI] ...
Journal Publication Open Access ResearchOnline@JCU
Palanisamy, Uma Devi; Sivanathan, Muniswaran; Radhakrishnan, Ammu Kutty; Haleagrahara, Nagajara; Sub...
Journal Publication Open Access ResearchOnline@JCU
Haleagrahara, Nagaraja; Chakravarthi, Srikumar; Mathews, Lisa (2011) 'Insulin like growth factor-1 (. International Journal of Mol, 12 (12):8562-8574. [DOI] ...
Journal Publication Open Access ResearchOnline@JCU
Jackie, Tan; Haleagrahara, Nagaraja; Chakravarthi, Srikumar (2011) 'Antioxidant effects of Etlingera. BMC Research Notes, 4 :1-8. [DOI] ...
Journal Publication Open Access ResearchOnline@JCU
Perera, Joachim; Tan, Joon Heng; Jeevathayaparan, S.; Chakravarthi, Srikumar; Haleagrahara, Nagaraja...
Journal Publication Open Access ResearchOnline@JCU
Haleagrahara, Nagaraja; Siew, Cheng Jun; Mitra, Nilesh Kumar; Kumari, Mangala (2011) 'Neuroprotectiv. Neuroscience, 500 (2):13...
Journal Publication Open Access ResearchOnline@JCU
Tudave, Dulanthi; Radhakrishnan, Ammu; Chakravarthi, Srikumar; Haleagrahara, Nagaraja (2011) 'Modula. 60 (...
Journal Publication Open Access ResearchOnline@JCU
Haleagrahara, Nagaraja; Varkkey, Julian; Chakravarthi, Srikumar (2011) 'Cardioprotective effects of . International Journal of M, 12 (10):7100-7113. [DOI ...
Journal Publication Open Access ResearchOnline@JCU
Haleagrahara, Nagaraja; Varkkey, Julian; Chakravarthi, Srikumar (2011) 'N-acetylcysteine offers card. 11 (4):373-381. [DOI] ...
Journal Publication Open Access ResearchOnline@JCU
Haleagrahara, Nagaraja; Jackie, Tan; Chakravarthi, Srikumar; Rao, Mallikarjuna; Pasupathi, Thanikach...
Journal Publication Open Access ResearchOnline@JCU
Haleagrahara, Nagaraja; Ponnusamy, Kumar (2010) 'Neuroprotective effect of Centella asiatica extract. 35 (1):41-47. [DOI] ...
Journal Publication Open Access ResearchOnline@JCU
Haleagrahara, Nagaraja; Radhakrishnan, Ammu; Lee, Nagarajah; Kumar, Pomnnusamy (2009) 'Flavonoid que. European Jo, 621 (1-3)...
Journal Publication Open Access ResearchOnline@JCU
Carlisle, Karen; Johnson, Peter; Mudd, Julie; Nagaraja, Haleagrahara; Moodley, Nishila (2023) ANZAHP...
Conference Contribution Open Access ResearchOnline@JCU