Preclinical Sciences

Esther Crouch

Esther Crouch

Karen Gerber

Karen Gerber

Jackie Picard

Jackie Picard

Orachun Hayakijkosol

Orachun Hayakijkosol

Rachel Bowater

Rachel Bowater

Sue Medlen

Sue Medlen

Linda Hayes

Linda Hayes

Tessa Mackie

Tessa Mackie

Robert Kinobe

Robert Kinobe

Constantin Constantinoiu

Constantin Constantinoiu

Ecological Impact of Antibiotic Resistance Released from the Cleveland Bay Purification Plant using Marine Turtle Species (Old ID 26730)
Robert Kinobe
31 Jan 2020 - 31 Jan 2023
Cleveland Bay is a grazing ground for turtle species. Cleveland Bay Purification plant (CBPP) treats waste that may contain a variety of antibiotics. This study aims to determine the prevalence and distribution patterns of antibiotic resistant genes in the CBPP effluent and in the immediate receiving environment.
Genotyping Australian Cats for ABCB1 Gene Mutation: Implications for Drug Sensitivity and Veterinary Pharmacogenomics
Robert Kinobe
30 Mar 2024 - 30 Mar 2025
The aim of this research is to determine the existence of the ABCB1 gene mutation in Australian domestic cats and its potential effect on drug induced toxicity. The ABCB1 gene encodes for P-glycoprotein, a membrane transporter that affects the absorption, tissue distribution, and elimination of many clinically used drugs. In the brain, this protein contributes to a blood-brain barrier that safeguards animals from chemical induced neurotoxicity. In dogs and cats, specific mutations in the ABCB1 gene introduce premature stop codons which disrupt the biosynthesis of this protein. These mutations are associated with increased drug movement into the brain, and increased susceptibility to drug induced adverse reactions. In North America, approximately 5% of domestic cats carry the ABCB1 gene mutation but its prevalence in Australian cats is not known. Our primary objective is to determine the frequency of ABCB1 gene mutation in Australian cats presenting with drug-induced neurologic toxicity. This information will be essential for improving drug safety in domestic cats.
Genotyping Australian Cats for ABCB1 Gene Mutation: Implications for Drug Sensitivity and Veterinary Pharmacogenomics
Robert Kinobe
30 Mar 2024 - 30 Dec 2026
The aim of this research is to determine the existence of the ABCB1 gene mutation in Australian domestic cats and its potential effect on drug induced toxicity. The ABCB1 gene encodes for P-glycoprotein, a membrane transporter that affects the absorption, tissue distribution, and elimination of many clinically used drugs. In the brain, this protein contributes to a blood-brain barrier that safeguards animals from chemical induced neurotoxicity. In dogs and cats, specific mutations in the ABCB1 gene introduce premature stop codons which disrupt the biosynthesis of this protein. These mutations are associated with increased drug movement into the brain, and increased susceptibility to drug induced adverse reactions. In North America, approximately 5% of domestic cats carry the ABCB1 gene mutation but its prevalence in Australian cats is not known. Our primary objective is to determine the frequency of ABCB1 gene mutation in Australian cats presenting with drug-induced neurologic toxicity. This information will be essential for improving drug safety in domestic cats.
Ecological Impact of Antibiotic Resistance Released from the Cleveland Bay Purification Plant using Marine Turtle Species (Old ID 26730)
Robert Kinobe
31 Jan 2020 - 31 Dec 2025
Cleveland Bay is a grazing ground for turtle species. Cleveland Bay Purification plant (CBPP) treats waste that may contain a variety of antibiotics. This study aims to determine the prevalence and distribution patterns of antibiotic resistant genes in the CBPP effluent and in the immediate receiving environment. Marine turtles in Cleveland Bay will be used to determine the localized impacts of both antibiotics and antibiotic resistant genes as compared to resident turtles from a pristine environment. This study will provide valuable insight into the direct effect that antibiotics and ARG’s in WWTP effluent have on ecological health and ecological risk.

Macrobrachium rosenbergii nodavirus (MrNV) in juvenile crustacea

  • 2012
  • Researchers:Orachun Hayakijkosol

An investigation to determine the cause of haemorrhagic enteritis in commercial pig grower units in the northern parts of South Africa

Ivermectin blocks the nuclear location signal of parvoviruses in crayfish, Cherax quadricarinatus

Heme oxygenase-1 overexpression exacerbates heart failure with aging and pressure overload but is protective against isoproterenol-induced cardiomyopathy in mice

A comparison of bacterial colonisation between Polyurethane and Polytetrafluroethylene (Teflon®) short term intravenous catheters in horses

Prolonged subcutaneous administration of oxytocin accelerates angiotensin II-induced hypertension and renal damage in male rats

A survey of zoonotic pathogens carried by non-indigenous rodents at the interface of the wet tropics of North Queensland, Australia

  • 2016
  • Wiley
  • Researchers:Jackie PicardBruce Gummow

Towards the elimination of excessive cobalt supplementation in racing horses: a pharmacological review

Oligonuclear polypyridylruthenium(II) complexes: selectivity between bacteria and eukaryotic cells

Carbon monoxide releasing molecule-3 alleviates angiotensin II-induced hypertrophy and apoptosis by inhibiting oxidative and endoplasmic reticulum stress in H9c2 cardiomyocytes

Title: GCE (Graduate Certificate of Education, Tertiary Teaching & Academic Practice), James Cook University
Reseracher: Robert Kinobe (Associate Professor)
Start Date: 01 Jan 2012
End Date: 01 Jan 2014
Title: DABVT, American Board of Veterinary Toxicology
Reseracher: Robert Kinobe (Associate Professor)
Start Date: 01 Jan 2024
Title: Bachelor of Veterinary Science, University of Queensland
Reseracher: Rachel Bowater (Lecturer, Veterinary Pathology)
Start Date: 01 Jan 1992
End Date: 01 Jan 1996
Title: Bachelor of Science (Honours), Sydney University
Reseracher: Rachel Bowater (Lecturer, Veterinary Pathology)
Start Date: 01 Jan 1985
End Date: 01 Jan 1989
Title: Member (by Examination only) of the Australian & New Zealand College of Veterinary Scientists, The Australian & New Zealand College of Veterinary Scientists
Reseracher: Rachel Bowater (Lecturer, Veterinary Pathology)
Start Date: 01 Jan 2002
End Date: 01 Jan 2002
Title: JCU veterinary researcher questions cobalt usage in horse racing, OzTREKK
Reseracher: Robert Kinobe (Associate Professor)
Title: New evidence claims some vitamins can lead to an accumulation of cobalt in horses, The Courier Mail
Reseracher: Robert Kinobe (Associate Professor)
Title: Good viruses and bad bacteria: a world-first green sea turtle trial, Phys.org
Reseracher: Robert Kinobe (Associate Professor)
Title: Good viruses and bad bacteria: A world-first green sea turtle trial, Science Daily News
Reseracher: Robert Kinobe (Associate Professor)
Title: Magnetic Island Network for Turtles
Reseracher: Rachel Bowater (Lecturer, Veterinary Pathology)
Start Date: 01 Jan 2020
End Date: 01 Jan 2030