Genotyping Australian Cats for ABCB1 Gene Mutation: Implications for Drug Sensitivity and Veterinary Pharmacogenomics

Principal Investigator

The aim of this research is to determine the existence of the ABCB1 gene mutation in Australian domestic cats and its potential effect on drug induced toxicity. The ABCB1 gene encodes for P-glycoprotein, a membrane transporter that affects the absorption, tissue distribution, and elimination of many clinically used drugs. In the brain, this protein contributes to a blood-brain barrier that safeguards animals from chemical induced neurotoxicity. In dogs and cats, specific mutations in the ABCB1 gene introduce premature stop codons which disrupt the biosynthesis of this protein. These mutations are associated with increased drug movement into the brain, and increased susceptibility to drug induced adverse reactions. In North America, approximately 5% of domestic cats carry the ABCB1 gene mutation but its prevalence in Australian cats is not known. Our primary objective is to determine the frequency of ABCB1 gene mutation in Australian cats presenting with drug-induced neurologic toxicity. This information will be essential for improving drug safety in domestic cats.

30 Mar 2024 - 30 Dec 2026

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