Preclinical Sciences

Esther Crouch

Esther Crouch

Karen Gerber

Karen Gerber

Jackie Picard

Jackie Picard

Orachun Hayakijkosol

Orachun Hayakijkosol

Rachel Bowater

Rachel Bowater

Sue Medlen

Sue Medlen

Linda Hayes

Linda Hayes

Tessa Mackie

Tessa Mackie

Robert Kinobe

Robert Kinobe

Constantin Constantinoiu

Constantin Constantinoiu

Ecological Impact of Antibiotic Resistance Released from the Cleveland Bay Purification Plant using Marine Turtle Species (Old ID 26730)
Robert Kinobe
31 Jan 2020 - 31 Jan 2023
Cleveland Bay is a grazing ground for turtle species. Cleveland Bay Purification plant (CBPP) treats waste that may contain a variety of antibiotics. This study aims to determine the prevalence and distribution patterns of antibiotic resistant genes in the CBPP effluent and in the immediate receiving environment.
Genotyping Australian Cats for ABCB1 Gene Mutation: Implications for Drug Sensitivity and Veterinary Pharmacogenomics
Robert Kinobe
30 Mar 2024 - 30 Mar 2025
The aim of this research is to determine the existence of the ABCB1 gene mutation in Australian domestic cats and its potential effect on drug induced toxicity. The ABCB1 gene encodes for P-glycoprotein, a membrane transporter that affects the absorption, tissue distribution, and elimination of many clinically used drugs. In the brain, this protein contributes to a blood-brain barrier that safeguards animals from chemical induced neurotoxicity. In dogs and cats, specific mutations in the ABCB1 gene introduce premature stop codons which disrupt the biosynthesis of this protein. These mutations are associated with increased drug movement into the brain, and increased susceptibility to drug induced adverse reactions. In North America, approximately 5% of domestic cats carry the ABCB1 gene mutation but its prevalence in Australian cats is not known. Our primary objective is to determine the frequency of ABCB1 gene mutation in Australian cats presenting with drug-induced neurologic toxicity. This information will be essential for improving drug safety in domestic cats.
Genotyping Australian Cats for ABCB1 Gene Mutation: Implications for Drug Sensitivity and Veterinary Pharmacogenomics
Robert Kinobe
30 Mar 2024 - 30 Dec 2026
The aim of this research is to determine the existence of the ABCB1 gene mutation in Australian domestic cats and its potential effect on drug induced toxicity. The ABCB1 gene encodes for P-glycoprotein, a membrane transporter that affects the absorption, tissue distribution, and elimination of many clinically used drugs. In the brain, this protein contributes to a blood-brain barrier that safeguards animals from chemical induced neurotoxicity. In dogs and cats, specific mutations in the ABCB1 gene introduce premature stop codons which disrupt the biosynthesis of this protein. These mutations are associated with increased drug movement into the brain, and increased susceptibility to drug induced adverse reactions. In North America, approximately 5% of domestic cats carry the ABCB1 gene mutation but its prevalence in Australian cats is not known. Our primary objective is to determine the frequency of ABCB1 gene mutation in Australian cats presenting with drug-induced neurologic toxicity. This information will be essential for improving drug safety in domestic cats.
Ecological Impact of Antibiotic Resistance Released from the Cleveland Bay Purification Plant using Marine Turtle Species (Old ID 26730)
Robert Kinobe
31 Jan 2020 - 31 Dec 2025
Cleveland Bay is a grazing ground for turtle species. Cleveland Bay Purification plant (CBPP) treats waste that may contain a variety of antibiotics. This study aims to determine the prevalence and distribution patterns of antibiotic resistant genes in the CBPP effluent and in the immediate receiving environment. Marine turtles in Cleveland Bay will be used to determine the localized impacts of both antibiotics and antibiotic resistant genes as compared to resident turtles from a pristine environment. This study will provide valuable insight into the direct effect that antibiotics and ARG’s in WWTP effluent have on ecological health and ecological risk.

Heme Oxygenase Activity in Fetal and Adult Ovine Tissue: Effects of High altitude-induced Long-term Hypoxemia

Heme oxygenase inhibition by 2-oxy-substituted 1-(1H-imidazol-1-yl)-4-phenylbutanes: Effect of halogen substitution in the phenyl ring

Preemptive heme oxygenase-1 gene delivery reveals reduced mortality and preservation of left ventricular function 1 yr after acute myocardial infarction

Differential expressions of FASN, SCD, and FABP4 genes in the ribeye muscle of omega-3 oil-supplemented Tattykeel Australian White lambs

Development of reference intervals for serum biochemistry and haematology of juvenile green sea turtles (Chelonia mydas) in a Thai rehabilitation centre

Toxoplasmosis epidemic in a population of urbanised allied rock‐wallabies "Petrogale assimilis" on Magnetic Island (Yunbenun), North Queensland

Yellow fever – An old foe with new developments

Multidecadal High Mortality Disease Events in Australian Domestic Geese Associated with a Novel Alphaherpesvirus, Designated Anatid Alphaherpevirus 2

Seroprevalence of melioidosis and its association with blood profiles and pathogens in sheltered dogs in southern Thailand

Multi-locus sequence typing and genetic diversity of antibiotic-resistant genes and virulence-associated genes in Burkholderia pseudomallei: Insights from whole genome sequencing of animal and environmental isolates in Thailand

Title: Lecturer, James Cook University
Reseracher: Orachun Hayakijkosol (Senior Lecturer)
Start Date: 01 Jan 2017
End Date: 01 Jan 2024
Title: Senior research officer, James Cook University
Reseracher: Orachun Hayakijkosol (Senior Lecturer)
Start Date: 01 Jan 2014
End Date: 01 Jan 2016
Title: Researcher, James Cook University
Reseracher: Orachun Hayakijkosol (Senior Lecturer)
Start Date: 01 Jan 2013
End Date: 01 Jan 2014
Title: Associate lecturer, James Cook University
Reseracher: Orachun Hayakijkosol (Senior Lecturer)
Start Date: 01 Jan 2013
End Date: 01 Jan 2014
Title: PhD (Aquatic microbiology), James Cook University
Reseracher: Orachun Hayakijkosol (Senior Lecturer)
Start Date: 01 Jan 2008
End Date: 01 Jan 2012
Title: Master Degree of Tropical Veterinary Science, James Cook University
Reseracher: Orachun Hayakijkosol (Senior Lecturer)
Start Date: 01 Jan 2007
End Date: 01 Jan 2008
Title: Bachelor Degree of Veterinary Science (2nd honour class), Mahidol University
Reseracher: Orachun Hayakijkosol (Senior Lecturer)
Start Date: 01 Jan 2000
End Date: 01 Jan 2006
Title: American Board of Veterinary Toxicology
Reseracher: Robert Kinobe (Associate Professor)
Start Date: 01 Jan 2024
Title: Australian and New Zealand College of Veterinary Scientists
Reseracher: Robert Kinobe (Associate Professor)
Start Date: 01 Jan 2012
Title: Australian Society of Veterinary Pathology
Reseracher: Rachel Bowater (Lecturer, Veterinary Pathology)
Start Date: 01 Jan 1997
End Date: 01 Jan 2027