Projects 3
Publications 19
Awards 11

Biography

Dr Socorro Miranda-Hernandez serves as a Postdoctoral Research Fellow at the Australian Institute of Tropical Health and Medicine, James Cook University (JCU). She holds a PhD in Biochemistry from JCU and a bachelor's degree in veterinary medicine from the Autonomous University of the State of Mexico.

Dr Miranda-Hernandez's research focuses on elucidating immunogenetic mechanisms underlying disease and conducting preclinical testing of innovative therapies and vaccines for human health applications. She employs a suite of spatial technologies, ranging from fundamental histopathological methods to advanced spatial tissue profiling techniques such as multiplex immunohistochemistry and image-based spatial molecular technology. She has extensive experience in biosafety containments levels 1 to 3 facilities and has developed her research in congenic, transgenic and knockout murine models of human diseases. She is driven by a commitment to translating scientific discovery into practical solutions to benefit communities, industry and policymakers.

Her intellectual contributions are reflected in publications in respected journals, and her achievements have been recognised with several awards from esteemed organisations including the Australian and New Zealand Society for Immunology, the Federation of Immunological Societies of Asia-Oceania, Host-Pathogen Interactions and Disease, JCU and the Autonomous University of the State of Mexico. Dr Miranda-Hernandez's research has also been supported by external grants, notably from the National Institutes of Health and the Validate network, which is supported by major international health and research funding bodies.

Over the past five years, she has played an integral role in projects investigating the immunogenetic mechanisms involved in the containment and reactivation of Latent Tuberculosis in immunocompromised hosts, conducting preclinical trials of novel vaccines for Tuberculosis, and exploring host-directed therapies to enhance control of that disease. Her work is characterised by a strong commitment to innovation and collaboration, aiming to make a meaningful impact on human health. 

Research

Projects

Teaching

Research Advisor Accreditation

Advisor Type

Secondary


Activities

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Education

Associations

Awards

Employment

Output

Miranda-Hernandez, Socorro; Kumar, Manoharan; Henderson, Alec; Graham, Erin; Tan, Xiao; Taylor, Jim; Meehan, Michael; Ceja, Zuriel; Del Pozo Ramos, Lidia Maria; Pan, Yi; Tsui, Ellen; Donovan, Meg L.; Rentería, Miguel E.; Flores-Valdez, Mario Alberto; Blumenthal, Antje; Nguyen, Quan; Subbian, Selvakumar; Field, Matt; Kupz, Andreas (2026) 'CD8+ T cells sustain vaccination-induced immunity against dissemination of contained tuberculosis in immunosuppressed hosts'. Nature Communications, 17 . [DOI]
Journal Publication Open Access ResearchOnline@JCU
Zhao, Guangzu; Sathkumara, Harindra D.; Miranda-Hernandez, Socorro; Seifert, Julia; Valencia Hernandez, Ana Maria; Puri, Munish; Huang, Wenbin; Toth, Istvan; Daly, Norelle; Skwarczynski, Mariusz; Kupz, Andreas (2025) 'A Modular Self-Assembling and Self-Adjuvanting Multiepitope Peptide Nanoparticle Vaccine Platform to Improve the Efficacy and Immunogenicity of BCG'. Small, 21 (7). [DOI]
Journal Publication ResearchOnline@JCU
Miranda-Hernandez, Socorro; Sathkumara Mudiyanselage, Harindra; Zhao, Guangzu; Schofield, Louis; Kupz, Andreas (2025) 'Co-administration of a synthetic saccharide conjugate vaccine with BCG provides synergistic protection against murine tuberculosis'. Vaccine, 68 . [DOI]
Journal Publication Open Access ResearchOnline@JCU
Blake, Judith A.; Seifert, Julia; Miranda-Hernandez, Socorro; Ruscher, Roland; Giacomin, Paul R.; Doolan, Denise L.; Kupz, Andreas (2025) 'Distal airway epithelial progenitors mediate TGF-β release to drive lung CD8+ TRM induction following mucosal BCG vaccination'. Mucosal Immunology, . [DOI]
Journal Publication Open Access ResearchOnline@JCU
Valencia-Hernandez, Ana Maria; Zhao, Guangzu; Miranda-Hernandez, Socorro; Segura-Cerda, Cristian Alfredo; Pedroza-Roldan, Cesar; Seifert, Julia; Aceves-Sanchez, Michel de Jesus; Burciaga-Flores, Mirna; Gutierrez-Ortega, Abel; del Pozo-Ramos, Lidia Maria; Flores-Valdez, Mario Alberto; Kupz, Andreas (2024) 'A second-generation recombinant BCG strain combines protection against murine tuberculosis with an enhanced safety profile in immunocompromised hosts'. Vaccine, 42 . [DOI]
Journal Publication Open Access ResearchOnline@JCU
McCulloch, Timothy R.; Rossi, Gustavo R.; Miranda-Hernandez, Socorro; Valencia-Hernandez, Ana Maria; Alim, Louisa; Belle, Clemence J.; Krause, Andrew; Zacchi, Lucia F.; Lam, Pui Yeng; Nakamura, Kyohei; Kupz, Andreas; Wells, Timothy J.; Souza-Fonseca-Guimaraes, Fernando (2024) 'The immune checkpoint TIGIT is upregulated on T cells during bacterial infection and is a potential target for immunotherapy'. Immunology and Cell Biology, 102 (8):721-733. [DOI]
Journal Publication Open Access ResearchOnline@JCU
Puri, Munish; Miranda-Hernandez, Socorro; Subbian, Selvakumar; Kupz, Andreas (2023) 'Repurposing mucosal delivery devices for live attenuated tuberculosis vaccines'. Frontiers in Immunology, 14 . [DOI]
Journal Publication Open Access ResearchOnline@JCU
Pant, Narayan; Miranda-Hernandez, Socorro; Rush, Catherine; Warner, Jeffrey; Eisen, Damon P. (2022) 'Non-Antimicrobial Adjuvant Therapy Using Ticagrelor Reduced Biofilm-Related Staphylococcus aureus Prosthetic Joint Infection'. Frontiers in Pharmacology, 13 . [DOI]
Journal Publication Open Access ResearchOnline@JCU
Pratap, Kunal; Majzoub, Marwan E.; Taki, Aya C.; Miranda Hernandez, Socorro; Magnusson, Marie; Glasson, Christopher; de Nys, Rocky; Thomas, Torsten; Lopata, Andreas L.; Kamath, Sandip D. (2022) 'The Algal Polysaccharide Ulvan and Carotenoid Astaxanthin Both Positively Modulate Gut Microbiota in Mice'. Foods, 11 (4). [DOI]
Journal Publication Open Access ResearchOnline@JCU
Pant, Narayan; Miranda-Hernandez, Socorro; Rush, Catherine; Warner, Jeffrey; Eisen, Damon P. (2022) 'Effect of savirin in the prevention of biofilm-related Staphylococcus aureus prosthetic joint infection'. Frontiers in Pharmacology, 13 . [DOI]
Journal Publication Open Access ResearchOnline@JCU
Heijmenberg, Isis; Husain, Aliabbas; Sathkumara Mudiyanse, Harindra D.; Muruganandah, Visai; Seifert, Julia; Miranda-Hernandez, Socorro; Kashyap, Rajpal Singh; Field, Matt A.; Krishnamoorthy, Gopinath; Kupz, Andreas (2021) 'ESX-5-targeted export of ESAT-6 in BCG combines enhanced immunogenicity & efficacy against murine tuberculosis with low virulence and reduced persistence'. Vaccine, 39 (50):7265-7276. [DOI]
Journal Publication ResearchOnline@JCU
Sathkumara, Harindra D.; Hansen, Karyina; Miranda-Hernandez, Socorro; Govan, Brenda; Rush, Catherine M.; Henning, Lars; Ketheesan, Natkunam; Kupz, Andreas (2020) 'Disparate effects of metformin on Mycobacterium tuberculosis infection in diabetic and nondiabetic mice'. Antimicrobial Agents and Chemotherapy, 65 (1). [DOI]
Journal Publication ResearchOnline@JCU
Nagaraja, Haleagrahara; Hodgson, Kelly; Miranda-Hernandez, Socorro; Hughes, Samuel; Bangra Kulur, Anupama; Ketheesan, Natkunam (2018) 'Flavonoid quercetin-methotrexate combination inhibits inflammatory mediators and matrix metalloproteinase expression, providing protection to joints in collagen-induced arthritis'. Inflammopharmacology, 26 (5):1219-1232. [DOI]
Journal Publication ResearchOnline@JCU
Haleagrahara, Nagaraja; Miranda-Hernandez, Socorro; Alim, Md Abdul; Hayes, Linda; Bird, Guy; Ketheesan, Natkunam (2017) 'Therapeutic effect of quercetin in collagen-induced arthritis'. Biomedicine & Pharmacotherapy, 90 :38-46. [DOI]
Journal Publication Open Access ResearchOnline@JCU
Gresle, Melissa M.; Schulz, Katrin; Jonas, Anna; Perreau, Victoria M.; Cipriani, Tania; Baxter, Alan G.; Miranda-Hernandez, Socorro; Field, Judith; Jokubaitis, Vilija G.; Cherny, Robert; Volitakis, Irene; David, Samuel; Kilpatrick, Trevor J.; Butzkueven, Helmut (2014) 'Ceruloplasmin gene-deficient mice with experimental autoimmune encephalomyelitis show attenuated early disease evolution'. Journal of Neuroscience Research, 92 (6):732-742. [DOI]
Journal Publication ResearchOnline@JCU
Quah, Hong Sheng; Miranda-Hernandez, Socorro; Khoo, Aimee; Harding, Ashley; Fynch, Stacey; Elkerbout, Lorraine; Brodnicki, Thomas C.; Baxter, Alan G.; Kay, Thomas W.H.; Thomas, Helen E.; Graham, Kate L. (2014) 'Deficiency in type I interferon signaling prevents the early interferon–induced gene signature in pancreatic islets but not type 1 diabetes in NOD mice'. Diabetes, 63 (3):1032-1040. [DOI]
Journal Publication ResearchOnline@JCU
Dickgreber, Nina; Farrand, Kathryn J.; van Panhuys, Nicholas; Knight, Deborah A.; McKee, Sara J.; Chong, Mei L.; Miranda-Hernandez, Socorro; Baxter, Alan G.; Locksley, Richard M.; Le Gros, Graham; Hermans, Ian F. (2012) 'Immature murine NKT cells pass through a stage of developmentally programmed innate IL-4 secretion'. Journal of Leukocyte Biology, 92 (5):999-1009. [DOI]
Journal Publication ResearchOnline@JCU
Miranda-Hernandez, Socorro; Gerlach, Nicole; Fletcher, Julie M.; Biros, Erik; Mack, Matthias ; Körner, Heinrich; Baxter, Alan G. (2011) 'Role for MyD88, TLR2 and TLR9 but not TLR1, TLR4 or TLR6 in experimental autoimmune encephalomyelitis '. Journal of Immunology, 187 (2):791-804. [DOI]
Journal Publication ResearchOnline@JCU
Miranda-Hernandez, Socorro; Baxter, Alan (2013) 'Role of toll-like receptors in multiple sclerosis' American Journal of Clinical and Experimental Immunology, 2 (1) :75-93.
Journal Contribution Open Access ResearchOnline@JCU