Community-wide distribution of long-lasting insecticidal nets can halt transmission of lymphatic filariasis in southeastern Nigeria

Journal Publication ResearchOnline@JCU

Richards, Frank O.;Emukah, Emmanuel;Graves, Patricia M.;Nkwocha, Omeni;Nwankwo, Lawrence;Rakers, Lindsay;Mosher, Aryc;Patterson, Amy;Ozaki, Masayo;Nwoke, Bertram E.B.;Ukaga, Chinyere N.;Njoku, Chidibere;Nowdu, Kendrick;Obasi, Andrew;Miri, Emmanuel S.

Patricia Graves

Abstract

Lymphatic filariasis (LF) in rural southeastern Nigeria is transmitted mainly by Anopheles spp. mosquitoes. Potential coinfection with Loa loa in this area has prevented use of ivermectin in the mass drug administration (MDA) strategy for LF elimination because of potential severe adverse L. loa-related reactions. This study determined if long-lasting insecticidal net (LLIN) distribution programs for malaria would interrupt LF transmission in such areas, without need for MDA. Monthly entomologic monitoring was conducted in sentinel villages before and after LLIN distribution to all households and all age groups (full coverage) in two districts, and to pregnant women and children less than five years of age in the other two districts. No change in human LF microfilaremia prevalence was observed, but mosquito studies showed a statistically significant decrease in LF infection and infectivity with full-coverage LLIN distribution. We conclude that LF transmission can be halted in southeastern Nigeria by full-coverage LLIN distribution, without MDA.

Journal

American Journal of Tropical Medicine and Hygiene

Publication Name

American Journal of Tropical Medicine and Hygiene

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1476-1645

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Publisher

American Society of Tropical Medicine and Hygiene

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DOI

10.4269/ajtmh.12-0775