photo

Thaddeus Wu

Projects

1

Publications

4

Awards

0

Contact Details

Lecturer, Computational Biologist / Bioinformatics Data Scientist

    Biography

    Dr Wu joined James Cook University in July 2022 as an Early Career Postdoctoral Researcher in A/Prof. Ulf Schmitz's team. Additionally, he holds the position of Lecturer in Mathematical and Computational Biology in the Department of Molecular & Cell Biology (CPHMVS).

    Thaddeus earned his PhD in Applied Mathematics from Monash University in March 2022. He conducts research in mathematical and computational biology, utilising his experience in mathematical modelling, algorithm development, and statistical analysis to study the mechanisms of cell fate determination.

    Currently, Thaddeus is focused on developing a novel mathematical framework to describe how mechanisms of alternative splicing and isoform expression at the single-cell level regulate cell fate determination.

    Available HDR Student Projects

    Research

    Research Interests

    Mathematical Modelling

    Mathematical and Computational Biology

    Systems Biology

    Stochastic Modelling

    Dynamical Systems

    Projects
    Innovative Therapeutic Strategies Targeting Aberrant Gene Regulation in Aggressive Breast Cancer
    01 Jul 2024 - 30 Jun 2025

    Teaching

    Research Advisor Accreditation
    Advisor Type

    Secondary

    Taught Modules
    [BM1000] Introductory Biochemistry and MicrobiologyTutor
    2022
    [BC3203] BioinformaticsTutor
    2023
    [TV1102] Cell Biology and Biochemistry for Veterinary Science and AgricultureTutor
    2022
    [BC5203] Advanced BioinformaticsTutor
    2022
    [BC5203] Advanced BioinformaticsLecturer
    2024
    [BC3203] BioinformaticsTutor
    2022
    [BC5203] Advanced BioinformaticsLecturer
    2023
    [BC3203] BioinformaticsLecturer
    2024
    Current JCU Research Students
    Neural network based model for cell type-specific isoform expression pattern
    Master of Philosophy (Medical, Molecular and Veterinary Sciences)

    Activities

    Associations
    Centre for Tropical Bioinformatics and Molecular Biology
    2022
    Australian Mathematical Society
    2022
    Languages
    Mandarin
    Chinese
    English
    Employment
    Postdoctoral Researcher and Lecturer, James Cook University
    2022

    Output

    Single-cell and long-read sequencing to enhance modelling of splicing and cell-fate determination
    2023
    Wu, Siyuan; Schmitz, Ulf (2023) 'Single-cell and long-read sequencing to enhance modelling of splici. Computational and Structural Biotechnology Journal, 21 :2373-2380. [DOI] ...
    Journal Publication ResearchOnline@JCU
    A robust method for designing multistable systems by embedding bistable subsystems
    2022
    Wu, Siyuan; Zhou, Tianshou; Tian, Tianhai (2022) 'A robust method for designing multistable systems . npj Systems Biology and Applications, 8 (10). [DOI] ...
    Journal Publication ResearchOnline@JCU
    A non-linear reverse-engineering method for inferring genetic regulatory networks
    2020
    Wu, Siyuan; Cui, Tiangang; Zhang, Xinan; Tian, Tianhai (2020) 'A non-linear reverse-engineering meth. PeerJ, 8 . [DOI] ...
    Journal Publication ResearchOnline@JCU
    Mathematical Modelling of Genetic Network for Regulating the Fate Determination of Hematopoietic Stem Cells
    2019
    Wu, Siyuan; Cui, Tiangang; Tian, Tianhai (2019) 2018 IEEE International Conference on Bioinformatics...
    Conference Publication ResearchOnline@JCU