Hillary Vanderven
- hillary.vanderven@jcu.edu.au
https://orcid.org/0000-0001-8482-2308- Senior Lecturer, Immunology/Infectious Disease
- Microbiology and Immunology
Projects
3
Publications
26
Awards
3
Contact Details
Senior Lecturer, Immunology/Infectious Disease
- 0747816799
- 0415164747
- hillary.vanderven@jcu.edu.au
Biography
Hillary Vanderven is a senior lecturer and researcher in the field of Immunology and Infectious Disease at James Cook University in Townsville.
Hillary graduated with a B.Sc. and an M.Sc. specialising in Immunology from the University of Alberta in Edmonton, Canada. She went on to work as a Research Assistant in Transplant Immunology and as a Biology Laboratory Coordinator for undergraduate science students. Hillary moved to Melbourne in 2014, where she completed her PhD under the supervision of Professor Stephen Kent. Her Doctoral thesis focused on characterising the human antibody response to influenza infection, vaccination and immunotherapy.
Hillary's current research investigates the immune system's response to viral and bacterial pathogens, with the aim of improving diagnosis, vaccination and treatment of infectious disease. Her major focus is understanding the immune mechanisms responsible for preventing or controlling influenza virus infections in humans. Primary areas of interest include enhancing influenza vaccine responsiveness in highly susceptible groups (such as older adults) and treating severe influenza with novel antibody-based therapies.
Research
Research Interests
- Immunology
- Influenza virus
Projects
Assessment of cytotoxicity induced by novel pMHC bi-specific antibodies in vitro (Old ID 27757)
14 Jul 2022 - 25 Jul 2023
Teaching
Research Advisor Accreditation
Advisor Type
Primary
Taught Modules
2022
[BM1110] Molecules to MicrobesLecturer
2024
[BM1110] Molecules to MicrobesLecturer
2025
[BM3000] Advanced Projects in BiomedicineCoordinator, Lecturer
2022
[BM3000] Advanced Projects in BiomedicineLecturer, Coordinator
2023
2022
2023
2022
2023
[BM5000] Advanced Projects in BiomedicineCoordinator, Lecturer
2022
[BM5000] Advanced Projects in BiomedicineLecturer, Coordinator
2024
[MI3061] Advanced ImmunobiologyLecturer
2022
[MI3061] Advanced ImmunobiologyLecturer
2023
[MI3061] Advanced ImmunobiologyLecturer
2025
[MI5061] Advanced ImmunologyLecturer
2023
[MI5061] Advanced ImmunologyLecturer
2024
[MI5061] Advanced ImmunologyLecturer
2025
2022
2023
2024
2025
[MI5061] Advanced ImmunologyLecturer
2022
2023
[BM3000] Advanced Projects in BiomedicineCoordinator, Lecturer
2025
[BM5000] Advanced Projects in BiomedicineCoordinator, Lecturer
2025
[MD3000] Selective StudyCoordinator
2021
2021
[BM3000] Advanced Projects in BiomedicineLecturer, Coordinator
2024
[BM5000] Advanced Projects in BiomedicineCoordinator, Lecturer
2023
Current JCU Research Students
Investigating antiviral activity of plant-derived antimicrobial compounds against influenza viruses
Doctor of Philosophy (Medical, Molecular and Veterinary Sciences)
The Characterisation and Utility of Australian Crocodylus porosus (Saltwater Crocodile) Skin Fibroblasts
Doctor of Philosophy (Medical, Molecular and Veterinary Sciences)
Completed JCU Research Students
Antibodies as Biomarkers of Tuberculosis Disease States
Master of Philosophy (Medical, Molecular and Veterinary Sciences)- 2025
Investigating potential co-factors of Fibropapillomatosis development in Chelonia mydas of the Great Barrier Reef;;
Doctor of Philosophy (Natural and Physical Sciences)- 2021
Current Honours and External Research Students
Induction of anti-neuraminidase antibodies by adjuvanted influenza vaccines
HONOURS- 2024
Completed Honours and External Research Students
The Q fever interferon gamma release assay: A novel approach for the detection of previous exposure to Coxiella burnetii
HONOURS
Tuberculosis in Papua New Guinea: A systems serology approach
HONOURS
Activities
Employment
PhD in Immunology, University of Melbourne
2014 - 2018
Awards
Output
Næss, Lisbeth M.; Vanderven, Hillary; Bryant-Bratlie, Danielle; Laake, Ida; Pleguezuelos, Olga; Oftung, Fredrik (2025) 'FLU-v, a Broad-Spectrum Peptide-Based Influenza Vaccine,
Induces NK Cell Activating IgG1 and IgG3 Subclass Antibodies
in Humans'. Vaccines, 13 (11). [DOI]
Chowdhury, Dibakar; Nayeem, Md.; Vanderven, Hillary A.; Sarker, Subir (2024) 'Role of miRNA in Highly Pathogenic H5 Avian Influenza Virus Infection: An Emphasis on Cellular and Chicken Models'. Viruses, 16 (7). [DOI]
Casazza, Joseph P.; Hofstetter, Amelia R.; Costner, Pamela J.M.; Holman, LaSonji A.; Hendel, Cynthia S.; Widge, Alicia T.; Wu, Richard L.; Whalen, William R.; Cunningham, Jennifer; Arthur, Anita; Wang, Xiaolin; Ola, Abidemi; Saunders, Jamie; Mendoza, Floreliz; Novik, Laura; Burgos Florez, Maria C.; Ortega-Villa, Ana M.; Apte, Preeti J.; Strom, Larisa; Wang, Lu; Imam, Marjaan; Basappa, Manjula; Naisan, Mursal; Castro, Mike; Trost, Jessica F.; Narpala, Sandeep R.; Vanderven, Hillary A.; Yamshchikov, Galina V.; Berkowitz, Nina M.; Gordon, Ingelise J.; Plummer, Sarah H.; Wycuff, Diane L.; Vazquez, Sandra; Gillespie, Rebecca A.; Creanga, Adrian; Adams, William C.; Carlton, Kevin; Gall, Jason G.; McDermott, Adrian B.; Serebryannyy, Leonid A.; Houser, Katherine V.; Koup, Richard A.; Graham, Barney S.; Ledgerwood, Julie E.; Mascola, John R.; Pierson, Theodore C.; Andrews, Sarah F.; Kanekiyo, Masaru; Dropulic, Lesia K.; The VRC 323 study team (2024) 'Phase 1 dose-escalation trial evaluating a group 2 influenza hemagglutinin stabilized stem nanoparticle vaccine'. NPJ Vaccines, 9 . [DOI]
Vanderven, Hillary; Wentworth, Deborah N.; Han, Win Min; Peck, Heidi; Barr, Ian G.; Davey, Richard T.; Beigel, John H.; Dwyer, Dominic E.; Jain, Mamta K.; Angus, Brian; Brandt, Christian T.; Mykietiuk, Analia; Law, Matthew G.; Neaton, James D.; Kent, Stephen J. (2023) 'Understanding the treatment benefit of hyperimmune anti-influenza intravenous immunoglobulin (Flu-IVIG) for severe human influenza'. JCI Insight, 8 (14). [DOI]
Vanderven, Hillary A.; Kent, Stephen J. (2023) 'Fc-mediated functions and the treatment of severe respiratory viral infections with passive immunotherapy – a balancing act'. Frontiers in Immunology, 14 . [DOI]
McIntyre, Sophie; Warner, Jeffrey; Rush, Catherine; Vanderven, Hillary A. (2023) 'Antibodies as clinical tools for tuberculosis'. Frontiers in Immunology, 14 . [DOI]
Kristensen, Anne B.; Wragg, Kathleen; Vanderven, Hillary; Lee, Wen Shi; Silvers, Julie; Kent, Helen E.; Grant, Michael D.; Kelleher, Anthony D.; Juno, Jennifer A.; Kent, Stephen J.; Parsons, Matthew S. (2022) 'Phenotypic and functional characteristics of highly differentiated CD57 +NKG2C + NK cells in HIV-1- infected individuals'. Clinical and Experimental Immunology, 210 (2):163-174. [DOI]
Vanderven, Hillary A.; Esterbauer, Robyn; Jegaskanda, Sinthujan; Tan, Hyon‐Xhi; Wheatley, Adam K.; Kent, Stephen J. (2022) 'Poor protective potential of influenza nucleoprotein antibodies despite wide prevalence'. Immunology and Cell Biology, 100 (1):49-60. [DOI]
Journal Publication
ResearchOnline@JCU
Vanderven, Hillary A.; Kent, Stephen J. (2020) 'The protective potential of Fc‐mediated antibody functions against influenza virus and other viral pathogens'. Immunology and Cell Biology, 98 :253-263. [DOI]
Journal Publication
ResearchOnline@JCU
Vanderven, Hillary A.; Barr, Ian; Reynaldi, Arnold; Wheatley, Adam K.; Wines, Bruce D.; Davenport, Miles P.; Hogarth, P. Mark; Kent, Stephen J. (2020) 'Fc functional antibody responses to adjuvanted versus unadjuvanted seasonal influenza vaccination in community-dwelling older adults'. Vaccine, 38 (10):2368-2377. [DOI]
Journal Publication
ResearchOnline@JCU
Tan, Hyon-Xhi; Esterbauer, Robyn; Vanderven, Hillary A.; Juno, Jennifer A.; Kent, Stephen J.; Wheatley, Adam K. (2019) 'Inducible bronchus-associated lymphoid tissues (iBALT) serve as sites of B cell selection and maturation following influenza infection in mice'. Frontiers in Immunology, 10 . [DOI]
Bangaru, Sandhya; Lang, Shanshan; Schotsaert, Michael; Vanderven, Hillary A.; Zhu, Xueyong; Kose, Nurgun; Bombardi, Robin; Finn, Jessica A.; Kent, Stephen J.; Gilchuk, Pavlo; Gilchuk, Iuliia; Turner, Hannah L.; García-Sastre, Adolfo; Li, Sheng; Ward, Andrew B.; Wilson, Ian A.; Crowe, James E. (2019) 'A site of vulnerability on the influenza virus hemagglutinin head domain trimer interface'. Cell, 177 (5):1136-1152. [DOI]
Journal Publication
ResearchOnline@JCU
Antibody-dependent cellular cytotoxicity responses to seasonal influenza vaccination in older adults
2018
Vanderven, Hillary A.; Jegaskanda, Sinthujan; Wines, Bruce D.; Hogarth, P. Mark; Carmuglia, Sarina; Rockman, Steven; Chung, Amy W.; Kent, Stephen J. (2018) 'Antibody-dependent cellular cytotoxicity responses to seasonal influenza vaccination in older adults'. Journal of Infectious Diseases, 217 (1):12-23. [DOI]
Journal Publication
ResearchOnline@JCU
Jegaskanda, Sinthujan; Vanderven, Hillary A.; Tan, Hyon-Xhi; Alcantara, Sheilajen; Wragg, Kathleen; Parsons, Matthew S.; Chung, Amy; Juno, Jennifer A.; Kent, Stephen J. (2018) 'Influenza infection enhances antibody-mediated NK cell functions via Type I interferon dependent pathways'. Journal of Virology, 9 (5). [DOI]
Journal Publication
ResearchOnline@JCU
Vanderven, Hillary A.; Wragg, Kathleen; Ana-Sosa-Batiz, Fernanda; Kristensen, Anne B.; Jegaskanda, Sinthujan; Wheatley, Adam K.; Wentworth, Deborah; Wines, Bruce D.; Hogarth, P. Mark; Rockman, Steve; Kent, Stephen J.; INSIGHT FLU005 Pilot Study Writing Group (2018) 'Anti-influenza hyperimmune immunoglobulin enhances Fc-functional antibody immunity during human influenza infection'. Journal of Infectious Diseases, 218 (9):1383-1393. [DOI]
Journal Publication
ResearchOnline@JCU
Bangaru, Sandhya; Zhang, Heng; Gilchuk, Iuliia M.; Voss, Thomas G.; Irving, Ryan P.; Gilchuk, Pavlo; Matta, Pranathi; Zhu, Xueyong; Lang, Shanshan; Nieusma, Travis; Richt, Juergen A.; Albrecht, Randy A.; Vanderven, Hillary A.; Bombardi, Robin; Kent, Stephen J.; Ward, Andrew B.; Wilson, Ian A.; Crowe, James E. (2018) 'A multifunctional human monoclonal neutralizing antibody that targets a unique conserved epitope on influenza HA'. Nature Communications, 9 . [DOI]
Vanderven, Hillary A.; Jegaskanda, Sinthujan; Wheatley, Adam K.; Kent, Stephen J. (2017) 'Antibody-dependent cellular cytotoxicity and influenza virus'. Current Opinion in Virology, 22 :89-96. [DOI]
Journal Publication
ResearchOnline@JCU
Vanderven, Hillary A.; Liu, Lu; Ana-Sosa-Batiz, Fernanda; Nguyen, Thi H.O.; Wan, Yanmin; Wines, Bruce; Hogarth, P. Mark; Tilmanis, Danielle; Reynaldi, Arnold; Parsons, Matthew S.; Hurt, Aeron C.; Davenport, Miles P.; Kotsimbos, Tom; Cheng, Allen C.; Kedzierska, Katherine; Zhang, Xiaoyan; Xu, Jianqing; Kent, Stephen J. (2017) 'Fc functional antibodies in humans with severe H7N9 and seasonal influenza'. JCI Insight, 2 (13):1-15. [DOI]
Journal Publication
ResearchOnline@JCU
Jegaskanda, Sinthujan; Vanderven, Hillary A.; Wheatley, Adam K.; Kent, Stephen J. (2017) 'Fc or not Fc; that is the question: antibody Fc-receptor interactions are key to universal influenza vaccine design'. Human Vaccines & Immunotherapeutics, 13 (6):1288-1296. [DOI]
Journal Publication
ResearchOnline@JCU
Ana-Sosa-Batiz, Fernanda; Vanderven, Hillary; Jegaskanda, Sinthujan; Johnston, Angus; Rockman, Steven; Laurie, Karen; Barr, Ian; Reading, Patrick; Lichtfuss, Marit; Kent, Stephen J. (2016) 'Influenza-specific antibody-dependent phagocytosis'. PLoS ONE, 11 (4). [DOI]
Parsons, Matthew S.; Richard, Jonathan; Lee, Wen Shi; Vanderven, Hillary; Grant, Michael D.; Finzi, Andrés; Kent, Stephen J. (2016) 'NKG2D acts as a co-receptor for natural killer cell-mediated anti-HIV-1 antibody-dependent cellular cytotoxicity'. AIDS Research and Human Retroviruses, 32 (10-11):1089-1096. [DOI]
Journal Publication
ResearchOnline@JCU
Wines, Bruce D.; Vanderven, Hillary A.; Esparon, Sandra E.; Kristensen, Anne B.; Kent, Stephen J.; Hogarth, P. Mark (2016) 'Dimeric FcγR ectodomains as probes of the Fc receptor function of anti-influenza virus IgG'. Journal of Immunology, 197 (4):1507-1516. [DOI]
Journal Publication
ResearchOnline@JCU
Vanderven, Hillary A.; Ana-Sosa-Batiz, Fernanda; Jegaskanda, Sinthujan; Rockman, Steven; Laurie, Karen; Barr, Ian; Chen, Weisan; Wines, Bruce; Hogarth, P. Mark; Lambe, Teresa; Gilbert, Sarah C.; Parsons, Matthew S.; Kent, Stephen J. (2016) 'What lies beneath: antibody dependent natural killer cell activation by antibodies to internal influenza virus proteins'. EBioMedicine, 8 :277-290. [DOI]
Kristensen, Anne B.; Lay, William N.; Ana-Sosa-Batiz, Fernanda; Vanderven, Hillary A.; Madhavi, Vijaya; Laurie, Karen L.; Carolan, Louise; Wines, Bruce D.; Hogarth, Mark; Wheatley, Adam K.; Kent, Stephen J. (2016) 'Antibody responses with Fc-mediated functions after vaccination of HIV-infected subjects with trivalent influenza vaccine'. Journal of Virology, 90 (12):5724-5734. [DOI]
Journal Publication
ResearchOnline@JCU
Vanderven, Hillary A.; Petkau, Kristina; Ryan-Jean, Kieran E.E.; Aldridge Jr., Jerry R.; Webster, Robert G.; Magor, Katharine E. (2012) 'Avian influenza rapidly induces antiviral genes in duck lung and intestine'. Molecular Immunology, 51 (3-4):316-324. [DOI]
Journal Publication
ResearchOnline@JCU
Vanderven, Hillary A.; Kent, Stephen J. (2025) 'Fc Functions and Anti-HIV Neutralizing Antibodies: A Perspective' Current HIV research, . [DOI]
Journal Contribution
ResearchOnline@JCU