Reprogramming-Evolving Path to Functional Surrogate β-Cells

Journal Publication ResearchOnline@JCU
Kalo, Eric;Read, Scott;Ahlenstiel, Golo
Eric Kalo
Abstract

Numerous cell sources are being explored to replenish functional β-cell mass since the proof-of -concept for cell therapy of diabetes was laid down by transplantation of islets. Many of these cell sources have been shown to possess a degree of plasticity permitting differentiation along new lineages into insulin-secreting β-cells. In this review, we explore emerging reprograming pathways that aim to generate bone fide insulin producing cells. We focus on small molecules and key transcriptional regulators that orchestrate phenotypic conversion and maintenance of engineered cells.

Journal

Cells

Publication Name

Cells

Volume

11

ISBN/ISSN

2073-4409

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N/A

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Pages Count

16

Location

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Publisher

MDPIAG

Publisher Url

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Publisher Location

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Publish Date

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Url

N/A

Date

N/A

EISSN

N/A

DOI

10.3390/cells11182813