Real-World Effectiveness of Sotrovimab in Patients Infected With SARS-CoV-2 Omicron Subvariant BA.2 in Western Sydney, Australia

Journal Publication ResearchOnline@JCU
Kalo, Eric;Basyouni, Ziad;Meyerowitz Katz, Gideon;Karkvandi, Vahid;Watson, Leanne;Crowther, Helen;Read, Scott;O'Sullivan, Matthew N.V.;Ellis, Jasmin;Medlin, Joanne;Ahlenstiel, Golo
Eric Kalo
Abstract

Laboratory-based findings suggest that Sotrovimab is significantly less effective against emerging CARS-CoV-2 variants, however, clinical data is lacking. Here we examined the effectiveness of sotrovimab, in preventing emergency department (ED) presentation and subsequent hospitalization in high-risk subgroups of patients during the SARS-CoV-2 Delta and Omicron waves in Western Sydney, Australia (n = 515). Risk for ED attendance was comparable in Omicron patients, whether BA.1 or BA.2, compared to Delta patients (hazard ratio of 0.97 [0.36–2.64]). These findings highlight the need for caution when using in vitro findings to drive clinical practice, especially when the consequence is to withhold potentially lifesaving treatment.

Journal

Journal of Medical Virology

Publication Name

Journal of Medical Virology

Volume

97

ISBN/ISSN

1096-9071

Edition

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Issue

2

Pages Count

5

Location

N/A

Publisher

Wiley

Publisher Url

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Publisher Location

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Publish Date

N/A

Url

N/A

Date

N/A

EISSN

N/A

DOI

10.1002/jmv.70235