Identification of defective early immune responses to Burkholderia pseudomallei infection in a diet-induced murine model of type 2 diabetes

Journal Publication ResearchOnline@JCU
Morris, Jodie L.;Govan, Brenda L.;Rush, Catherine M.;Ketheesan, Natkunam
Jodie MorrisCatherine Rush
Abstract

Co-occurrence of bacterial infections with type 2 diabetes (T2D) is a global problem. Melioidosis caused by Burkholderia pseudomallei is 10 times more likely to occur in patients with T2D, than in normoglycemic individuals. Using an experimental model of T2D, we observed that greater susceptibility in T2D was due to differences in proportions of infiltrating leucocytes and reduced levels of MCP-1, IFN-γ and IL-12 at sites of infection within 24 h post-infection. However, by 72 h the levels of inflammatory cytokines and bacteria were markedly higher in visceral tissue and blood in T2D mice. In T2D, dysregulated early immune responses are responsible for the greater predisposition to B. pseudomallei infection.

Journal

Microbes and Infection

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Volume

23

ISBN/ISSN

1769-714X

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Issue

4-5

Pages Count

6

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Publisher

Elsevier

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Date

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EISSN

N/A

DOI

10.1016/j.micinf.2021.104793