Do genes sensitive to insufficient folate increase the occurrence of cleft lip and palate in humans? (Old ID 31123)
Role
Chief Investigator
Description
Cleft lip +/- palate is the most frequent birth deformity. Although associated with lower socioeconomic status and malnutrition, there is currently no explanation for its occurrence. Folate deficiency (vitamin B9) has been implicated in the occurrence of cleft lip and palate. Using samples from affected persons and their parents, this project will examine the function of specific genes known to require adequate folate and involved in facial development. If altered gene expression is found, personalised preconception folate supplementation may prevent the occurrence of this lifelong deformity.
Date
01 Feb 2024 - 31 Jan 2025
Project Type
GRANT
Keywords
Cleft Lip;Folate uptake & metabolism;Gene Expression;DNA Methylation;Epigenetics;Nutrigenomics
Funding Body
Australian and New Zealand Association of Oral and Maxillofacial Surgeons Research and Education Foundation and Trust
Amount
30000
Project Team
Daniel Browne;Ulf Schmitz;Doris Pierce