Metformin for treating peripheral artery disease-related walking impairment (MERIT) (Old ID 27481)
Role
Chief Investigator
Description
Blockage of the leg arteries (peripheral artery disease; PAD) leads to severe pain, walking impairment and a substantial risk of leg amputation and death. Over 20,000 North Queenslanders have PAD which is overrepresented in regional, remote and rural populations. There are currently no effective PAD medications. Multiple lines of evidence suggest that metformin, a cheap and safe medication, promotes formation of new vessels, improves microcirculation and muscle function and limits PAD-related pain. This placebo-controlled, randomised clinical trial, run by a North Queensland vascular research collaboration, will examine the efficacy of metformin in improving walking ability of PAD patients.
Date
22 Feb 2022 - 22 Feb 2024
Project Type
GRANT
Keywords
Prevention;Complications;Preipheral artery disease;Risk Factors
Funding Body
Tropical Australian Academic Health Centre Limited
Amount
50000
Project Team
Joseph Moxon;Alkira Deren