Plasticity of muscle derived stem cells to undergo pluripotent conversion without pluripotency factors or small molecules

Induction of pluripotency in somatic cells from multiple origins have been, in vogue since almost a decade using pluripotency factors/genes, Oct3/4, Sox2, Klf4, c-Myc, Lin28 and small molecules like inhibitors of BMP2, MAP kinase and GSK3β. Here, we show the induced pluripotency of otherwise, multipotent, muscle derived stem cells (MDSC) obtained from hind limb muscles of myostatin null (Mstn-/-) mouse.Induction of pluripotency in somatic cells from multiple origins have been, in vogue since almost a decade using pluripotency factors/genes, Oct3/4, Sox2, Klf4, c-Myc, Lin28 and small molecules like inhibitors of BMP2, MAP kinase and GSK3β. Here, we show the induced pluripotency of otherwise, multipotent, muscle derived stem cells (MDSC) obtained from hind limb muscles of myostatin null (Mstn-/-) mouse.

Cytotherapy

Cytotherapy

16

14653249

N/A

4

1