Recommendations for Epstein-Barr virus–based screening for nasopharyngeal cancer in high- and intermediate-risk regions

Journal Publication ResearchOnline@JCU

Lam, W. K.Jacky;King, Ann D.;Miller, Jacob A.;Liu, Zhiwei;Yu, Kelly J.;Chua, Melvin L.K.;Ma, Brigette B.Y.;Chen, Ming Yuan;Pinsky, Benjamin A.;Lou, Pei Jen;Woo, John K.S.;Hsu, Wan-Lun;Simon, Julia;Doolan, Denise L.;Waterboer, Tim;Hui, Edwin P.;Li, Hui;Tsang, Raymond K.;Wong, Kenneth C.W.;Goh, Julian P.;Vlantis, Alexander C.;Ai, Qi Yong;Wong, Lun M.;Abdullah, Victor;Lin, Jin Ching;Chen, Chien Jen;Pfeiffer, Ruth M.;Le, Quynh Thu;Lee, Anne W.M.;Ji, Mingfang;Cao, Sumei;Ma, Jun;Chan, Anthony T.C.;Chan, K. C.Allen;Hildesheim, Allan

Denise Doolan

Abstract

A meeting of experts was held in November 2021 to review and discuss available data on performance of Epstein-Barr virus (EBV)–based approaches to screen for early stage nasopharyngeal carcinoma (NPC) and methods for the investigation and management of screen-positive individuals. Serum EBV antibody and plasma EBV DNA testing methods were considered. Both approaches were found to have favorable performance characteristics and to be cost-effective in high-risk populations. In addition to endoscopy, use of magnetic resonance imaging (MRI) to investigate screen-positive individuals was found to increase the sensitivity of NPC detection with minimal impact on cost-effectiveness of the screening program.

Journal

Journal of the National Cancer Institute

Publication Name

Journal of the National Cancer Institute

Volume

115

ISBN/ISSN

1460-2105

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Publisher

Oxford University Press

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DOI

10.1093/jnci/djad012