A short commentary on potential role of the IFN-γ/mini-TrpRS signaling axis in abdominal aortic aneurysm

Journal Contribution ResearchOnline@JCU
Moran, Corey S.;Velu, Ramesh B.;Vangaveti, Venkat;Malabu, Usman H.;Biros, Erik
Venkat Vangaveti
Abstract

Aneurysms demonstrate vascular smooth muscle cells (VSMC) phenotypic modulation characterized by the prevailing of synthetic over contractile properties. We have shown previously the ability of interferon-gamma (IFN-γ) to switch VSMC from contractile to synthetic phenotype via upregulating the truncated form of tryptophanyl-tRNA synthetase (mini-TrpRS) in vitro. Here we discuss a possible role of the IFN-γ/mini-TrpRS signalling axis in the pathology of human abdominal aortic aneurysm (AAA).

Journal

Archives of Clinical and Biomedical Research

Publication Name

Archives of Clinical and Biomedical Research

Volume

4

ISBN/ISSN

2572-9292

Edition

N/A

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Pages Count

6

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Publisher

Fortune Journals

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Publisher Location

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Date

N/A

EISSN

N/A

DOI

10.26502/acbr.50170109