Appropriate comparisons of tuberculosis latency structures with empiric data

Nicolas Menzies and colleagues1 presented a systematic review of the latency structures used in tuberculosis models, which was similar to our 2017 review.2 The main additional contribution of this latest work is the detailed literature search that provides a complete picture of the range of structures in use and highlights the variability in approaches. We strongly agree with the finding that modelled reactivation profiles differ profoundly between studies and that many commonly used structures and parameters fit empirical data poorly. The parameter range findings on goodness of fit validate the results of both studies. However, important differences between the reviews in the two empirical comparison datasets should be highlighted.

Lancet Infectious Diseases

Lancet Infectious Diseases

18

1474-4457

N/A

7

2