Antibody-dependent cellular cytotoxicity and influenza virus

Vanderven, Hillary A.;Jegaskanda, Sinthujan;Wheatley, Adam K.;Kent, Stephen J.

Abstract

Antibodies are a key defence against influenza infection and disease, but neutralizing antibodies are often strain-specific and of limited utility against divergent or pandemic viruses. There is now considerable evidence that influenza-specific antibodies with Fc-mediated effector functions, such as antibody-dependent cellular cytotoxicity (ADCC), can assist in the clearance of influenza infection in vitro and in animal models. Further, ADCC-mediating antibodies that recognize a broad array of influenza strains are common in humans, likely as a result of being regularly exposed to influenza infections. The concept that influenza-specific ADCC can assist in the partial control of influenza infections in humans is gaining momentum. This review examines the utility of influenza specific ADCC antibodies.

Journal

Current Opinion in Virology

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Current Opinion in Virology

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1879-6265

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Elsevier

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DOI

10.1016/j.coviro.2016.12.002