Macrosomia in non-gestational diabetes pregnancy: glucose tolerance test characteristics and feto-maternal complications in tropical Asia Pacific Australia

Objective: To look into the glucose tolerance test characteristics and determine non-gestational diabetes pregnant subjects. Methods: From 2006 to 2009 all non-gestational diabetes mellitus (non-GDM) pregnant women who delivered macrosomia at the North Australia's Townsville Hospital were retrospectively reviewed by extracting data from clinical record. Glucose tolerance tests results were analysed in the light of an earlier diagnosis of non-GDM. Results: Ninety-one non-GDM mothers with macrosomia were studied and compared with 41 normoglycemic subjects without macrosomia. Of the subjects with non-GDM macrosomia 45 (49.4%) had normal 50g glucose challenge test (GCT) without further testing, another 8 (8.8%) had abnormal GCT but normal 75g oral glucose tolerance test (OGTT). 4 (4.4%) subjects had normal GCT and OGTT. Interestingly 14 out of 16 (87.5%) subjects who were tested with OGTT owing to past history of macrosomia had normal results but delivered macrosomic Only 12 subjects had both GCT and OGTT, the rest of the cohort had either of the 2 tests. Subjects with non-GDM macrosomia had higher frequency of neonatal hypoglycaemia 34% as compared to 10% in non-macrosomic babies p = 0.003. Other feto-maternal complications were similar in both groups. Conclusion: No significant pattern of glucose tolerance characteristics was identified in non-GDM mothers with macrosomic babies. In spite of being normoglycemic significant neonatal hypoglycaemia was recorded in non-GDM macrosomic babies. Further prospective studies on a larger population are needed to verify our findings.

Asian Pacific journal of tropical biomedicine

Asia Pacific Journal of Tropical Biomedicine

4

2221-1691

N/A

6

5