Determining the crystal purity of mebendazole raw material and stability in suspension by DRA-UV-spectroscopy, ATR-FTIR spectroscopy and ANN spectral modelling

[Extract] Mebendazole, methyl 5-benzoyl benzimidazole-2-carbamate, a broadspectrum anthelmintic drug exists in three polymorphic forms (A, B, C) with different solubilities and thermodynamic stabilities [1]. Due to its poor solubility, the more soluble, but less stable Form C is therapeutically favoured in drug formulations such as suspensions [2]. The objectives of this work were to develop simple, direct and non-destructive procedures to identify and quantify crystal purity of mebendazole raw material and to establish stability of the preferred Form C in a suspension formulation.

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Farmacevtski Vestnik

59

0014-8229

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2