Principles of therapeutic drug monitoring: a case of drug-resistant epilepsy in a dog

Drug analysis for purposes of monitoring therapeutic outcomes is not a common practice in veterinary medicine but may be extremely valuable in many circumstances including; clinical cases in which there is a poor correlation between dose and drug plasma concentration, and therapeutic or toxic effects, confirmation of drug-induced toxicity for medications with very low therapeutic indices, assessment of compliance with the drug administration and assessing the occurrence of drug-drug interactions. Therapeutic drug monitoring may also be indicated for patients with altered physiological states such as renal, thyroid and hepatic disease, and electrolyte imbalances. In this article, a clinical case of canine idiopathic epilepsy with an apparent resistance to antiepileptic drug therapy is used to illustrate some of the basic principles of therapeutic drug monitoring (TMD).

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Chapter of Veterinary Pharmacology, Science Week 2011

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