A genetic polymorphism in transforming growth factor beta receptor 2 is associated with serum osteopontin

Biros, E.;Clancy, P.;Norman, P.E.;Golledge, J.

Abstract

Osteopontin (OPN) is a secreted glycoprotein demonstrated to play an important role in inflammation. Transforming growth factor beta and a related signalling pathway have been implicated in control of OPN secretion. We examined the relationship between transforming growth factor beta receptor-1 and -2 (TGFBR1 and 2) single nucleotide polymorphisms (SNP) and serum OPN in 296 men from the Health in Men Study. Serum concentrations of OPN and 58 SNPs for TGFBR1 and 2 were assessed. One SNP in TGFBR2 was associated with serum OPN (TGFBR2 g.20690C > T, SNP ID rs4522809, P = 0.0007) after adjusting for multiple testing. This study suggests that polymorphism in TGFBR2 are associated with altered secretion of OPN, supporting a role for transforming growth factor beta in OPN production.

Journal

International Journal of Immunogenetics

Publication Name

International Journal of Immunogenetics

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ISBN/ISSN

1744-313X

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Publisher

Blackwell

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DOI

10.1111/j.1744-313X.2009.00855.x