Defining immunodominance in a complex host-pathogen system. (Old ID 22489)

Principal Investigator

Immunodominance is the phenomenon whereby pathogen-specific immune responses do not target the full range of possible peptide epitopes derived from the genome but recognize only a small fraction of the epitopes. It has been studied primarily in experimental infection models using simple organisms (viruses and bacteria). Herein, we propose the first comprehensive investigation of immunodominance in the context of a complex host-pathogen system: Plasmodium falciparum malaria in humans. These studies will provide valuable new knowledge of host-pathogen immunity and facilitate rational vaccine design.

01 Jan 2014 - 31 Dec 2018

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