Richard Keene
- richard.keene@jcu.edu.au
- Adjunct Professor
- Australian Institute of Tropical Health & Medicine
Projects
0
Publications
12
Awards
0
Biography
Over the last two decades, the laboratory of F Richard Keene has been an international pioneer in the development of techniques to control the stereochemistry of the component metal centres in mononuclear and oligonuclear metal complexes.
The methodologies – using a combination of stereoselective synthesis and chromatography – have allowed the routine separation of diastereoisomers, the resolution of enantiomers, the separation of geometric isomers, and the separation of chiral helical forms.
Output
Xu, Xinyue; Martin, Samuel J.P.; Flint, Kate L.; Hudson, Rohan J.; Keene, F. Richard; Hall, Christopher H.; Smith, Trevor A. (2024) 'Photophysical Studies of Helicate and Mesocate Double-Stranded Dinuclear Ru(II) Complexes'. Journal of Physical Chemistry: Part A, 128 :3587-3595. [DOI]
Journal Publication
ResearchOnline@JCU
Wardhani, Kartika; Levina, Aviva; Sun, Biyun; Zou, Haipei; Grau, Georges E.R.; Keene, Richard; Collins, J. Grant; Lay, Peter A. (2024) 'Tetranuclear Polypyridylruthenium(II) Complexes as Selective Nucleic Acid Stains for Flow Cytometric Analysis of Monocytic and Epithelial Lung Carcinoma Large Extracellular Vesicles'. Biomolecules, 14 (6). [DOI]
Wardhani, Kartika; Levina, Aviva; Sun, Biyun; Grau, Georges E.R.; Keene, F. Richard; Collins, J. Grant; Lay, Peter A. (2023) 'A tetranuclear polypyridylruthenium(ii) complex as a selective stain for extracellular vesicle penetration through brain microvascular endothelium'. Chemical Communications, 59 :6877-6880. [DOI]
Journal Publication
ResearchOnline@JCU
Flint, Kate L.; Huang, David M.; Linder-Patton, Oliver M.; Sumby, Christopher J.; Keene, F. Richard (2022) 'Synthesis of Triple-Stranded Diruthenium(II) Compounds'. European Journal of Inorganic Chemistry, 2022 (25). [DOI]
Sun, Biyun; Sundaraneedi, Madhu K.; Southam, Hannah M.; Poole, Robert K.; Musgrave, Ian F.; Keene, F. Richard; Collins, J. Grant (2019) 'Synthesis and biological properties of tetranuclear ruthenium complexes containing the bis[4(4'-methyl-2,2'-bipyridyl)]-1,7-heptane ligand'. Dalton Transactions, 48 (38):14505-14515. [DOI]
Fairbanks, Simon D.; Robertson, Craig C.; Keene, F. Richard; Thomas, Jim A.; Williamson, Mike P. (2019) 'Structural investigation into the threading intercalation of a chiral dinuclear ruthenium(II) polypyridyl complex through a B‑DNA oligonucleotide'. Journal of the American Chemical Society, 141 (11):4644-4652. [DOI]
Journal Publication
ResearchOnline@JCU
Flint, Kate L.; Collins, J. Grant; Bradley, Siobhan J.; Smith, Trevor A.; Sumby, Christopher J.; Keene, F. Richard (2019) 'Synthesis and characterisation of helicate and mesocate forms of a double-stranded diruthenium(II) complex of a di(terpyridine) ligand'. Australian Journal of Chemistry, 72 (10):762-768. [DOI]
Journal Publication
ResearchOnline@JCU
Sundaraneedi, Madhu; Eichenberger, Ramon M.; Al-Hallaf, Rafid; Yang, Dai; Sotillo, Javier; Rajan, Siji; Wangchuk, Phurpa; Giacomin, Paul R.; Keene, F. Richard; Loukas, Alex; Collins, J. Grant; Pearson, Mark S. (2018) 'Polypyridylruthenium(II) complexes exert in vitro and in vivo nematocidal activity and show significant inhibition of parasite acetylcholinesterases'. International Journal for Parasitology: Drugs and Drugs Resistance, 8 (1):1-7. [DOI]
Sun, Biyun; Southam, Hannah M.; Butler, Jonathan A.; Poole, Robert K.; Burgun, Alexandre; Tarzia, Andrew; Keene, F. Richard; Collins, J. Grant (2018) 'Synthesis, isomerisation and biological properties of mononuclear ruthenium complexes containing the bis[4(4'-methyl-2,2'-bipyridyl)]-1,7-heptane ligand'. Dalton Transactions, 47 :2422-2434. [DOI]
Li, Xin; Gorle, Anil K.; Sundaraneedi, Madhu K.; Keene, F. Richard; Collins, J. Grant (2018) 'Kinetically-inert polypyridylruthenium(II) complexes as therapeutic agents'. Coordination Chemistry Reviews, 375 :134-147. [DOI]
Journal Publication
ResearchOnline@JCU
Liu, Xuewen; Sun, Biyun; Kell, Ruby E.M.; Southam, Hannah M.; Butler, Jonathan A.; Li, Xin; Poole, Robert K.; Keene, F. Richard; Collins, J. Grant (2018) 'The antimicrobial activity of mononuclear ruthenium(II) complexes containing the dppz ligand'. ChemPlusChem, 83 :643-650. [DOI]
Journal Publication
ResearchOnline@JCU
Sun, Biyun; Musgrave, Ian F.; Day, Anthony I.; Heimann, Kirsten; Keene, F. Richard; Collins, J. Grant (2018) 'Eukaryotic cell toxicity and HSA binding of [Ru(Me4phen)(bb7)]2+ and the effect of encapsulation in cucurbit[10]uril'. Frontiers in Chemistry, 6 . [DOI]