Norelle Daly
- norelle.daly@jcu.edu.au
- Professorial Research Fellow
- Australian Institute of Tropical Health & Medicine
Projects
3
Publications
24
Awards
0
Biography
Professor Daly was awarded her PhD from the University of Queensland. Her studies involved using NMR spectroscopy to determine the structure of domains of the LDL receptor; a receptor critical for the control of cholesterol levels. Following these studies she was involved in establishing a new field of research involving plant derived cyclic peptides. This work resulted in several granted patents and the establishment of a small biotechnology company associated with The University of Queensland.
Norelle has published more than 170 journal articles, 3 book chapters, been awarded a UQ Research Excellence Award, awarded a National Breast Cancer Foundation Novel Concept award, and held a NHMRC Industry Fellowship, a Queensland Smart State Fellowship and an ARC Future Fellowship.
Research
Projects
Development of a novel wound healing agent (Old ID 28948)
01 Apr 2023 - 30 Mar 2024
An integrated, multi-model bio-layer interferometry facility (Old ID 26412)
01 Jan 2020 - 31 Dec 2020
Development of disulfide-rich peptides for drug design (Old ID 19353)
01 Mar 2012 - 31 Dec 2016
Teaching
Research Advisor Accreditation
Advisor Type
Mentor
Research Advisor Accreditation
Role
Chair; Independent Academic
Output
Peck, Yoshimi; Pickering, Darren; Mobli, Mehdi; Liddell, Michael J.; Wilson, David T; Ruscher, Roland; Ryan, Stephanie; Buitrago, Geraldine; McHugh, Connor; Love, Nicholas C.; Pinlac, Theresa; Haertlein, Michael; Kron, Michael A.; Loukas, Alex; Daly, Norelle L. (2024) 'Solution structure of the N-terminal extension domain of a Schistosoma japonicum asparaginyl-tRNA synthetase'. Journal of Biomolecular Structure and Dynamics, 42 (15):7934-7944. [DOI]
Giribaldi, Julien; Chemin, Jean; Tuifua, Marie; Deuis, Jennifer R.; Mary, Rosanna; Vetter, Irina; Wilson, David T; Daly, Norelle L.; Schroeder, Christina I.; Bourinet, Emmanuel; Dutertre, Sébastien (2023) 'Pmu1a, a novel spider toxin with dual inhibitory activity at pain targets hNaV1.7 and hCaV3 voltage-gated channels'. FEBS Journal, 290 (14):3688-3702. [DOI]
Journal Publication
ResearchOnline@JCU
Dongol, Yashad; Wilson, David T.; Daly, Norelle L.; Cardoso, Fernanda C.; Lewis, Richard J. (2023) 'Structure-function and rational design of a spider toxin Ssp1a at human voltage-gated sodium channel subtypes'. Frontiers in Pharmacology, 14 . [DOI]
Takjoo, Rozita; Wilson, David T.; Bansal, Paramjit S.; Loukas, Alex; Smout, Michael J.; Daly, Norelle L. (2023) 'Identification of an inter-cysteine loop potentially involved in the activity of Opisthorchis viverrini-granulin-1'. Exploration of Drug Science, 1 :172-179. [DOI]
Schmidt, Casey A.; Cooke, Ira; Wilson, David T.; Miller, David J.; Peigneur, Steve; Tytgat, Jan; Field, Matthew; Takjoo, Rozita; Smout, Michael J.; Loukas, Alex; Daly, Norelle L. (2022) 'Newly Discovered Peptides from the Coral Heliofungia actiniformis Show Structural and Functional Diversity'. Journal of Natural Products, 85 (7):1789-1798. [DOI]
Journal Publication
ResearchOnline@JCU
Faraji, Naser; Arab, Seyed Shahriar; Doustmohammadi, Alireza; Daly, Norelle L.; Khosroushahi, Ahmad Yari (2022) 'ApInAPDB: a database of apoptosis-inducing anticancer peptides'. Scientific Reports, 12 . [DOI]
Ritmejeryte, Edita; Ryan, Rachael Y.M.; Byatt, Brendan J.; Peck, Yoshimi; Yeshi, Karma; Daly, Norelle L.; Zhao, Guangzu; Crayn, Darren; Loukas, Alex; Pyne, Stephen G.; Ruscher, Roland; Wangchuk, Phurpa (2022) 'Anti-inflammatory properties of novel galloyl glucosides isolated from the Australian tropical plant Uromyrtus metrosideros'. Chemico-Biological Interactions, 368 . [DOI]
Journal Publication
ResearchOnline@JCU
Cobos, Claudia; Bansal, Paramjit S.; Wilson, David T.; Jones, Linda; Zhao, Guangzu; Field, Matthew A.; Eichenberger, Ramon M.; Pickering, Darren A.; Ryan, Rachael Y.M.; Ratnatunga, Champa N.; Miles, John J.; Ruscher, Roland; Giacomin, Paul R.; Navarro, Severine; Loukas, Alex; Daly, Norelle L. (2022) 'Peptides derived from hookworm anti-inflammatory proteins suppress inducible colitis in mice and inflammatory cytokine production by human cells'. Frontiers in Medicine, 9 . [DOI]
Buitrago, Geraldine; Pickering, Darren; Ruscher, Roland; Cobos Caceres, Claudia; Jones, Linda; Cooper, Martha; Van Waardenberg, Ashley; Ryan, Stephanie; Miles, Kim; Field, Matthew; Dredge, Keith; Daly, Norelle L.; Giacomin, Paul R.; Loukas, Alex (2021) 'A netrin domain-containing protein secreted by the human hookworm Necator americanus protects against CD4 T cell transfer colitis'. Translational Research, 232 :88-102. [DOI]
Dongol, Yashad; Choi, Phil M.; Wilson, David T.; Daly, Norelle L.; Cardoso, Fernanda C.; Lewis, Richard J. (2021) 'Voltage-Gated Sodium Channel Modulation by a New Spider Toxin Ssp1a Isolated From an Australian Theraphosid'. Frontiers in Pharmacology, 12 . [DOI]
Daly, Norelle L.; Wilson, David T. (2021) 'Plant derived cyclic peptides'. Biochemical Society Transactions, 49 (3):1279-1285. [DOI]
Malik, Uru; Chan, Lai Yue; Cai, Minying; Hruby, Victor J.; Kaas, Quentin; Daly, Norelle L.; Craik, David J. (2021) 'Development of novel frog-skin peptide scaffolds with selectivity towards melanocortin receptor subtypes'. Peptide Science, 113 (4). [DOI]
Journal Publication
ResearchOnline@JCU
Giribaldi, Julien; Haufe, Yves; Evans, Edward R.J.; Wilson, David T.; Daly, Norelle L.; Enjalbal, Christine; Nicke, Annette; Dutertre, Sébastien (2021) 'Synthesis, structural and pharmacological characterizations of CIC, a novel α-conotoxin with an extended n-terminal tail'. Marine Drugs, 19 (3). [DOI]
Sharp, Michael F.; Taki, Aya C.; Ruethers, Thimo; Stephen, Juan N.; Daly, Norelle L.; Lopata, Andreas L.; Kamath, Sandip D. (2021) 'IgE and IgG4 epitopes revealed on the major fish allergen Lat c 1'. Molecular Immunology, 131 :155-163. [DOI]
Khudhair, Zainab; Alhallaf, Rafid; Eichenberger, Ramon M.; Whan, Jen; Kupz, Andreas; Field, Matt; Krause, Lutz; Wilson, David T.; Daly, Norelle L.; Giacomin, Paul; Sotillo, Javier; Loukas, Alex (2021) 'Gastrointestinal helminth infection improves insulin sensitivity, decreases systemic inflammation, and alters the composition of gut microbiota in distinct mouse models of Type 2 diabetes'. Frontiers in Endocrinology, 11 . [DOI]
Wilson, David; Bansal, Paramjit S.; Carter, David A.; Vetter, Irina; Nicke, Annette; Dutertre, Sébastien; Daly, Norelle (2020) 'Characterisation of a novel A-superfamily conotoxin'. Biomedicines, 8 (5). [DOI]
Schmidt, Casey A.; Wilson, David T.; Cooke, Ira; Potriquet, Jeremy; Tungatt, Katie; Muruganandah, Visai; Boote, Chloe; Kuek, Felicity; Miles, John J.; Kupz, Andreas; Ryan, Stephanie; Loukas, Alex; Bansal, Paramjit S.; Takjoo, Rozita; Miller, David J.; Peigneur, Steve; Tytgat, Jan; Daly, Norelle (2020) 'Identification and characterization of a peptide from the stony coral Heliofungia actiniformis'. Journal of Natural Products, 83 (11):3454-3463. [DOI]
Journal Publication
ResearchOnline@JCU
Giribaldi, Julien; Haufe, Yves; Evans, Evans R.J.; Amar, Muriel; Durner, Anna; Schmidt, Casey; Faucherre, Adèle; Moha Ou Maati, Hamid; Enjalbal, Christine; Molgó, Jordi; Servent, Denis; Wilson, David T.; Daly, Norelle L.; Nicke, Annette (2020) 'Backbone cyclization turns a venom peptide into a stable and equipotent ligand at both muscle and neuronal nicotinic receptors'. Journal of Medicinal Chemistry, 63 (21):12682-12692. [DOI]
Journal Publication
ResearchOnline@JCU
Evans, Edward R.J.; McIntyre, Lachlan; Northfield, Tobin; Daly, Norelle L.; Wilson, David T. (2020) 'Small molecules in the venom of the scorpion Hormurus waigiensis'. Biomedicines, 8 (8). [DOI]
Takjoo, Rozita; Wilson, David T.; Bansal, Paramjit; Loukas, Alex; Smout, Michael J.; Daly, Norelle L. (2020) 'Folding of truncated granulin peptides'. Biomolecules, 10 (8). [DOI]
Ng, Susanna S.; Rivera, Fabian De Labastida; Yan, Juming; Corvino, Dillon; Das, Indrajit; Zhang, Ping; Kuns, Rachel; Chauhan, Shashi Bhushan; Hou, Jiajie; Li, Xian-Yang; Frame, Teija C.M.; McEnroe, Benjamin A.; Moore, Eilish; Na, Jinrui; Engel, Jessica A.; Soon, Megan S. F.; Singh, Bhawana; Kueh, Andrew J.; Herold, Marco J.; de Oca, Marcela Montes; Singh, Siddharth Sankar; Bunn, Patrick T.; Aguilera, Amy Roman; Casey, Mika; Braun, Matthias; Ghazanfari, Nazanin; Wani, Shivangi; Wang, Yulin; Amante, Fiona; Edwards, Chelsea L.; Haque, Ashraful; Dougall, William C.; Singh, Om Prakash; Baxter, Alan G.; Teng, Michele W.L.; Loukas, Alex; Daly, Norelle L.; Cloonan, Nicole; Degli-esposti, Mariapia; Uzonna, Jude; Heath, William R.; Bald, Tobias; Tey, Siok-Keen; Nakamura, Kyohei; Hill, Geoffrey R.; Kumar, Rajiv; Sundar, Shyam; Smyth, Mark J; Engwerda, Christian R. (2020) 'The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation'. Nature Immunology, 21 :1205-1217. [DOI]
Journal Publication
ResearchOnline@JCU
Fingerhut, Legana C. H. W.; Miller, David J.; Strugnell, Jan M.; Daly, Norelle L.; Cooke, Ira R. (2020) 'ampir: an R package for fast genome-wide prediction of antimicrobial peptides'. Bioinformatics, 36 (21). [DOI]
Journal Publication
ResearchOnline@JCU
Yeshi, Karma; Ruscher, Roland; Hunter, Luke; Daly, Norelle; Loukas, Alex; Wangchuk, Phurpa (2020) 'Revisiting inflammatory bowel disease: pathology, treatments, challenges and emerging therapeutics including drug leads from natural products'. Journal of Clinical Medicine, 9 (5). [DOI]
Synthesis, pharmacological and structural characterization of novel conopressins from Conus miliaris
2020
Giribaldi, Julien; Ragnarsson, Lotten; Pujante, Tom; Enjalbal, Christine; Wilson, David; Daly, Norelle L.; Lewis, Richard J.; Dutertre, Sebastien (2020) 'Synthesis, pharmacological and structural characterization of novel conopressins from Conus miliaris'. Marine Drugs, 18 (3). [DOI]