Exploration of homodimer receptor: homodimer protein interactions
Journal Publication ResearchOnline@JCUVera, Julio;Kwon, Taesoo;Schmitz, Ulf;Kolch, Walter;Wolkenhauer, Olaf
Abstract
Homodimerisation is producing a protein?protein complex composed of two identical molecules. Dimerisation is a phenomenon often occurring in the regulation of biochemical systems like signal transduction pathways. We investigated whether the existence of a homodimer-activated receptor and the activation of homodimer transducers correspond to a more general pattern in cell signalling. We developed a workflow to merge data from the Gene Ontology and the BIND database to produce a list of interactions between homodimer receptors and homodimer proteins. Finally, we found a prevalence of homodimer-homodimer interactions in signalling systems in human cells.
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5
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1744-5493
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4
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11
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Inderscience
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