A conditional nature for the synthetical lethality between defects in lipid and peptidoglycan biosynthesis
Journal Contribution ResearchOnline@JCUHong, Yaoqin;Qin, Jilong;Totsika, Makrina
Abstract
[Extract] We write to provide an alternative view on the synthetic lethality between lipid and peptidoglycan synthesis (fabH and nlpI) reported in a recent PNAS article, “Cross-talk between phospholipid synthesis and peptidoglycan expansion by a cell wall hydrolase” by Som and Reddy (1). Our viewpoint centers on the conditional nature of this lethality, driven by the weakened cell envelope's inability to withstand compressive turgor pressure.
Journal
Proceedings of the National Academy of Sciences of the United States of America
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Volume
120
ISBN/ISSN
1091-6490
Edition
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Issue
52
Pages Count
2
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Publisher
National Academy of Sciences
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EISSN
N/A
DOI
10.1073/pnas.2318882120