Abstract
MicroRNAs (miRNAs) are small regulatory RNAs of ~22nt length that regulate the activity and stability of a large number of messenger RNAs (Bartel 2004; Ambros 2004; Filipowicz et al. 2008). miRNAs bind to specific messenger RNAs and target them for cleavage, deadenylation, or translational repression. In all three processes, protein synthesis of the targeted messenger RNA is prevented. Until today, a vast amount of human miRNAs has been detected (1.524 human miRNAs are listed in the ▶ miRBase database, r18). Many of them are involved in the regulation of relevant cellular processes, including cell signaling, metabolism, apoptosis, and developmental processes (Ambros 2004).
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Encyclopedia of Systems Biology
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9781441998637
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8
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Springer Nature
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New York, NY, USA
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