bla ROB-1 Presence on pB1000 in Haemophilus influenzae Is Widespread, and Variable Cefaclor Resistance Is Associated with Altered Penicillin-Binding Proteins

Journal Publication ResearchOnline@JCU
Tristram, Stephen G.;Littlejohn, Rachael;Bradbury, Richard S.
Abstract

Plasmid pB1000 is a small replicon recently identified as bearing blaROB-1 in animal and human Pasteurellaceae in Spain. We identified pB1000 in 11 blaROB-1-positive Australian and North American Haemophilus influenzae isolates, suggesting a wider role for pB1000 in disseminating blaROB-1. Native H. influenzae conjugative elements can mobilize plasmids similar to pB1000 at a low frequency of 10−8, and this might account for the infrequency of blaROB-1 compared to the rate of occurrence of blaTEM-1. Altered penicillin-binding protein 3 was associated with an increased cefaclor MIC in 3 isolates.

Journal

Antimicrobial Agents and Chemotherapy

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N/A

Volume

54

ISBN/ISSN

1098-6596

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Issue

11

Pages Count

3

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Publisher

American Society for Microbiology

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Publisher Location

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Publish Date

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Date

N/A

EISSN

N/A

DOI

10.1128/aac.00263-10