Assessment and Treatment of Hepatitis C Virus Infection Among People Who Inject Drugs in the Opioid Substitution Setting: ETHOS Study
Journal Publication ResearchOnline@JCUAbstract
Background: Access to hepatitis C virus (HCV) treatment remains extremely limited among people who inject drugs (PWID). HCV assessment and treatment was evaluated through an innovative model for the provision of HCV care among PWID with chronic HCV infection. Methods: Enhancing Treatment for Hepatitis C in Opioid Substitution Settings (ETHOS) was a prospective observational cohort. Recruitment was through 5 opioid substitution treatment (OST) clinics, 2 community health centers, and 1 Aboriginal community controlled health organization in New South Wales, Australia. Results: Among 387 enrolled participants, mean age was 41 years, 71% were male, and 15% were of Aboriginal ethnicity. Specialist assessment was undertaken in 191 (49%) participants, and 84 (22%) commenced interferon-based treatment. In adjusted analysis, HCV specialist assessment was associated with non-Aboriginal ethnicity (adjusted odds ratio [AOR], 4.02; 95% confidence interval [CI], 2.05–7.90), no recent benzodiazepine use (AOR, 2.06; 95% CI, 1.31–3.24), and non-1 HCV genotype (AOR, 2.13; 95% CI, 1.32–3.43). In adjusted analysis, HCV treatment was associated with non-Aboriginal ethnicity (AOR, 4.59; 95% CI, 1.49–14.12), living with the support of family and/or friends (AOR, 2.15; 95% CI, 1.25–3.71), never receiving OST (AOR, 4.40; 95% CI, 2.27–8.54), no recent methamphetamine use (AOR, 2.26; 95% CI, 1.12–4.57), and non-1 HCV genotype (AOR, 3.07; 95% CI, 1.67–5.64). Conclusions: HCV treatment uptake was relatively high among this highly marginalized population of PWID. Potentially modifiable factors associated with treatment include drug use and social support.
Journal
Clinical Infectious Diseases
Publication Name
N/A
Volume
57
ISBN/ISSN
1537-6591
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Issue
S2
Pages Count
8
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Publisher
Oxford University Press
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Publisher Location
JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
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EISSN
N/A
DOI
10.1093/cid/cit305